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Using Atlas-driven Imaging for Determining Variations in Velopharyngeal Function Among Children with Cleft Palate and Hypernasal Speech

Award Number: R01DE027989
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/10/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Using Atlas-driven Imaging for Determining Variations in Velopharyngeal Function Among Children with Cleft Palate and Hypernasal Speech - PROJECT SUMMARY Cleft lip and palate is the most prevalent birth defect in the United States affecting one out of every 577 births. Despite advances in surgery, it is estimated that 25-38% of children with a repaired cleft palate will continue to have hypernasal speech due to insufficient velopharyngeal closure, requiring additional surgeries. Although nasal endoscopy is frequently used to determine the type of surgery, it provides only limited views of the movements of speech. Insufficient information is available from current diagnostic technologies to visualize the location of muscles and their quantitative functional arrangement in the child. Magnetic resonance imaging (MRI) provides excellent visualization of soft tissue structures, such as muscles, but has traditionally been too slow to capture speech dynamics where complete contractions may occur in 100 ms. The current proposal develops a dynamic MRI imaging method that can image the full vocal tract in 3D+time with high spatial and high temporal resolution, achieving 166 frames per second (FPS) for the entire volume. Specifically, a dynamic speech imaging technique will be developed that is suitable for application in children aged 5-8 years old, a critical age range for re-repair of cleft palate in secondary surgical management. The technique integrates a spatiotemporal atlas that describes the mean motions across a population of healthy children for particular speech samples. The imaging technique leverages the atlas to: improve the quality of the reconstructed images, automatically label edges for quantitative analysis, and focuses the analysis on variances in motion from one subject compared to the healthy atlas. In order to examine the dependency of the population mean atlas on sex, race, and dialect, spatiotemporal atlases will be developed at three different geographical sites, with 40 healthy children ages 5-8 years old at each site, with equal numbers of both sexes and equal numbers of two races. Additionally, we will recruit 45 cleft palate patients ages 5-8 years old following cleft palate repair with and without velopharyngeal insufficiency with resulting hypernasality. We will apply our imaging technique to examine temporal characteristics of velopharyngeal muscle function, determining movement differences related to hypernasality.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Oral Diseases and Disorders Research	000	4	6/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $676,593 )
2022	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Oral Diseases and Disorders Research	001	4	7/1/2022	SUPPLEMENT FOR EXPANSION	$32,515
2022	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Oral Diseases and Disorders Research	000	4	6/30/2022	NON-COMPETING CONTINUATION	$644,078
														Subtotal = $676,593

Issue Date FY: 2021 ( Subtotal = $720,248 )
2021	2021	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Oral Diseases and Disorders Research	000	2	11/18/2020	SUPPLEMENT FOR EXPANSION	$29,907
2021	2021	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Oral Diseases and Disorders Research	001	3	5/20/2021	NON-COMPETING CONTINUATION	$690,341
														Subtotal = $720,248

Issue Date FY: 2020 ( Subtotal = $646,939 )
2020	2020	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Oral Diseases and Disorders Research	001	2	5/27/2020	NON-COMPETING CONTINUATION	$666,919
2020	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Oral Diseases and Disorders Research	000	1	12/3/2019	NEW	-$19,980
														Subtotal = $646,939

Issue Date FY: 2019 ( Subtotal = $704,597 )
2019	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Oral Diseases and Disorders Research	000	1	7/10/2019	NEW	$704,597
														Subtotal = $704,597

Grand Total All Awards = $2,748,377

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Using Atlas-driven Imaging for Determining Variations in Velopharyngeal Function Among Children with Cleft Palate and Hypernasal Speech

Award Number: R01DE027989

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/10/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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