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Peptide-Polymer Engineering Dentin/Adhesive Interfacial Bond Integrity

Award Number: R01DE025476
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/12/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Peptide-Polymer Engineering Dentin/Adhesive Interfacial Bond Integrity - Project Summary The cycle of repeated composite-restoration replacements is a pernicious problem—each replacement risks pulpal injury, increased tooth weakness, and eventually, tooth loss. The problem is pervasive—nearly 70% of all composite restorations are replacements and the leading cause of failure is recurrent marginal decay. Unlike amalgam, composite lacks the inherent capability to seal discrepancies at the material/tooth interface. The adhesive that bonds the composite to the tooth is intended to seal the interface, but the adhesive seal to dentin is fragile—it is readily damaged by acids, enzymes, and other oral fluids. Bacteria and bacterial by-products infiltrate the resulting marginal gaps, demineralize and decompose the tooth, and further erode the adhesive, leading to wider and deeper gaps that create an ideal environment for bacteria to proliferate. Biodegradation by- products accumulate at the dentin/adhesive interface and increase the virulence of cariogenic bacteria, provoking a positive feedback loop that escalates the degradation. There is an urgent need to address this composite/tooth-interface vulnerability through multi-factorial approaches that: i) remineralize damaged dentin; ii) inhibit bacterial attack; and iii) provide durable polymers. Recent findings from our lab offer significant promise for meeting this need. First, we have synthesized novel self-strengthening polymers—the self-strengthening mechanism provides a persistent, intrinsic reinforcement of the polymer network in both neutral and acidic conditions. We have engineered antimicrobial and remineralizing peptides and tethered them to self- strengthening-adhesive monomers. Building on our progress, we propose to use both engineered peptides and antibacterial agents tethered to novel polymers to provide a “bio-hybrid” adhesive that will serve as a durable barrier to recurrent decay. Our threefold strategy exploits: (i) polymer-tethered engineered peptides and antibacterial agents to simultaneously provide antibacterial activity, delay biofilm formation, and remineralize dentin; (ii) self-strengthening polymers that resist hydrolysis-mediated degradation; and (iii) iterative feedback between synthesis, characterization, and modeling to forecast performance under relevant in vivo conditions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $282,093 )
2024	2024	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	10	8/1/2024	NON-COMPETING CONTINUATION	$282,093
														Subtotal = $282,093

Issue Date FY: 2023 ( Subtotal = $359,813 )
2023	2023	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	9	7/27/2023	NON-COMPETING CONTINUATION	$359,813
														Subtotal = $359,813

Issue Date FY: 2022 ( Subtotal = $356,214 )
2022	2022	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	001	8	8/9/2022	NON-COMPETING CONTINUATION	$356,214
2022	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	7	1/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $356,214

Issue Date FY: 2021 ( Subtotal = $359,813 )
2021	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	002	7	7/16/2021	NON-COMPETING CONTINUATION	$359,813
2021	2020	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	001	6	2/28/2021	COMPETING CONTINUATION	$13
2021	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	5	2/28/2021	NON-COMPETING CONTINUATION	-$13
														Subtotal = $359,813

Issue Date FY: 2020 ( Subtotal = $359,813 )
2020	2020	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	001	6	8/12/2020	COMPETING CONTINUATION	$359,813
2020	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	5	8/5/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $359,813

Issue Date FY: 2019 ( Subtotal = $143,273 )
2019	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	5	7/17/2019	NON-COMPETING CONTINUATION	$143,273
														Subtotal = $143,273

Issue Date FY: 2018 ( Subtotal = $288,616 )
2018	2018	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	4	8/1/2018	NON-COMPETING CONTINUATION	$288,616
														Subtotal = $288,616

Issue Date FY: 2017 ( Subtotal = $364,048 )
2017	2017	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	3	7/28/2017	NON-COMPETING CONTINUATION	$364,048
														Subtotal = $364,048

Issue Date FY: 2016 ( Subtotal = $364,487 )
2016	2016	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL ROAD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	2	6/30/2016	NON-COMPETING CONTINUATION	$364,487
														Subtotal = $364,487

Issue Date FY: 2015 ( Subtotal = $358,912 )
2015	2015	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL ROAD	LAWRENCE	KS	66045	DOUGLAS	USA	Oral Diseases and Disorders Research	000	1	8/6/2015	NEW	$358,912
														Subtotal = $358,912

Grand Total All Awards = $3,237,082

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Peptide-Polymer Engineering Dentin/Adhesive Interfacial Bond Integrity

Award Number: R01DE025476

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/12/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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