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Effects of Biofilm Activities and Dental Resin Composite Compositions on the Deve

Award Number: R01DE021391
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2010
PERIOD OF PERFORMANCE END DATE: 08/31/2014

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Effects of Biofilm Activities and Dental Resin Composite Compositions on the Deve - DESCRIPTION (provided by applicant): The primary objectives of this project are to better understand the factors that lead to the development of secondary caries and to identify strategies to increase the service life of resin composite restorations. Restoration replacements due to secondary caries occupies a large portion of the dentist's practices. In 1999, 86 million composites were placed by dentists in this country and 122.7 million in 2006. The average replacement time is now only 5.7 years. Significant improvements in the long-term integrity of so many restorations could save the American people (by reducing costs of replacing restorations) many times the amount of money required to support this work. There is tremendous significance in the successful pursuit of this endeavor to benefit so many millions of people. We propose to study the effects of biofilm activity and dental resin composite compositions on the development of secondary caries. We will use a bioreactor model that utilizes conditions found in the oral environment to understand the role of microbial biofilms, salivary pellicles, and cyclic loading in the processes of secondary caries formation. While the bioreactor model establishes the conditions for the cyclic remineralization/demineralization attacks, we will use a variety of oral-simulating challenges and analytical methods to assess their effects on composite-restored teeth. We hypothesize that major contributors to defects at restoration margins include: interfacial stresses from contractions induced by polymerization shrinkage of resins, salivary esterases, acidogenic microbe-generated biofilms, and deformations from cyclic loading and oral thermal fluctuations. These can lead to subsequent staining, secondary caries, fractures, or other problems. The long-term goals of this project are to identify and prepare an optimally cross-linking composite composition resin that can restore defective teeth and defy environmental degradation (Aim 1); determine the effects of polymerization shrinkage on the development of degradation at the tooth-composite interface (Aim 2); understand the roles of salivary pellicles and microbial biofilms in the etiology of secondary caries' association with composite restorations (Aim 3); and develop beneficial biofilms in synergy with fluoride therapies that have the potential of retarding the onset of secondary caries (Aim 4). Our goal is to understand the physical, chemical and biological factors that determine the length of time a restoration lasts. With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations. PUBLIC HEALTH RELEVANCE: This project is focused on developing strategies to increase the service life of resin composite restorations. Our goal is to understand the physical, chemical and biological factors that determine the length of time a restoration lasts. With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2013	UNIVERSITY OF COLORADO DENVER	P.O.BOX 6508	AURORA	CO	80045	ADAMS	USA	Oral Diseases and Disorders Research	000	5	8/20/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $301,266 )
2013	2013	UNIVERSITY OF COLORADO DENVER	P.O. BOX 6508	AURORA	CO	80045	ADAMS	USA	Oral Diseases and Disorders Research	000	5	7/31/2013	NON-COMPETING CONTINUATION	$301,266
														Subtotal = $301,266

Issue Date FY: 2012 ( Subtotal = $313,211 )
2012	2012	UNIVERSITY OF COLORADO DENVER	P.O. BOX 6508	AURORA	CO	80045	ADAMS	USA	Oral Diseases and Disorders Research	002	4	7/12/2012	NON-COMPETING CONTINUATION	$313,211
2012	2011	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	2	2/22/2012	NON-COMPETING CONTINUATION	-$344,850
2012	2011	UNIVERSITY OF COLORADO DENVER	P.O. BOX 6508	AURORA	CO	80045	ADAMS	USA	Oral Diseases and Disorders Research	001	3	2/22/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$344,850
														Subtotal = $313,211

Issue Date FY: 2011 ( Subtotal = $363,750 )
2011	2011	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	2	7/18/2011	NON-COMPETING CONTINUATION	$363,750
														Subtotal = $363,750

Issue Date FY: 2010 ( Subtotal = $375,000 )
2010	2010	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	001	1	9/14/2010	NEW	$0
2010	2010	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	1	9/10/2010	NEW	$375,000
														Subtotal = $375,000

Grand Total All Awards = $1,353,227

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Effects of Biofilm Activities and Dental Resin Composite Compositions on the Deve

Award Number: R01DE021391

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2010

PERIOD OF PERFORMANCE END DATE: 08/31/2014

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