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Patterning the Vertebrate Dentition Through Replacement and Repair

Award Number: R01DE019637
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2010
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Patterning the Vertebrate Dentition Through Replacement and Repair - Project Summary/Abstract The broad goal of the proposed research is to understand molecular mechanisms of tooth regeneration and tissue renewal in vertebrates. Our research benefits from explicit integration of experimental systems (cichlid fishes, zebrafish, mouse) and a unique approach translating new biology from fishes to mammals and back. In this competitive renewal application, we build on the previous project period to outline three Specific Aims that fuse unbiased and experimental approaches in multiple vertebrate tooth models to identify cell populations and molecular signals that direct natural whole-tooth replacement (cichlids and zebrafish) and mouse incisor tissue renewal. The gaps we aim to fill are significant. One in five humans presents with a genetic disorder affecting the dentition and nearly 100% develop problems (e.g, cavities) with age. 30% of people worldwide over the age of 65 lack teeth entirely. Our proposed research will provide answers to the basic question of how regenerating teeth are partitioned into coordinated zones of renewal and differentiation, and how mammalian teeth recover from damage. Insights should promote innovative strategies for bio-inspired regenerative dentistry.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$55,828 )
2025	2022	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Oral Diseases and Disorders Research	001	12	7/2/2025	NON-COMPETING CONTINUATION	-$55,828
2025	2022	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Oral Diseases and Disorders Research	000	12	12/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = -$55,828

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	12	1/31/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $537,315 )
2022	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	001	12	4/21/2022	NON-COMPETING CONTINUATION	$48,849
2022	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	12	2/10/2022	NON-COMPETING CONTINUATION	$488,466
														Subtotal = $537,315

Issue Date FY: 2021 ( Subtotal = $542,742 )
2021	2021	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	11	2/18/2021	NON-COMPETING CONTINUATION	$542,742
														Subtotal = $542,742

Issue Date FY: 2020 ( Subtotal = $542,742 )
2020	2020	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Oral Diseases and Disorders Research	000	10	2/6/2020	NON-COMPETING CONTINUATION	$542,742
														Subtotal = $542,742

Issue Date FY: 2019 ( Subtotal = $607,492 )
2019	2019	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Oral Diseases and Disorders Research	002	9	9/19/2019	COMPETING CONTINUATION	$201,441
2019	2019	GEORGIA TECH RESEARCH CORPORATION	505 10TH ST NW	ATLANTA	GA	30318	FULTON	USA	Oral Diseases and Disorders Research	000	9	3/5/2019	COMPETING CONTINUATION	$607,492
2019	2017	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Oral Diseases and Disorders Research	001	8	9/19/2019	NON-COMPETING CONTINUATION	-$201,441
														Subtotal = $607,492

Issue Date FY: 2017 ( Subtotal = $316,376 )
2017	2017	GEORGIA TECH RESEARCH CORPORATION	505 10TH ST NW	ATLANTA	GA	30318	FULTON	USA	Oral Diseases and Disorders Research	000	8	1/31/2017	NON-COMPETING CONTINUATION	$284,738
2017	2017	GEORGIA TECH RESEARCH CORPORATION	505 10TH ST NW	ATLANTA	GA	30318	FULTON	USA	Oral Diseases and Disorders Research	001	8	5/26/2017	NON-COMPETING CONTINUATION	$31,638
														Subtotal = $316,376

Issue Date FY: 2016 ( Subtotal = $317,080 )
2016	2016	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	7	1/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$317,080
														Subtotal = $317,080

Issue Date FY: 2015 ( Subtotal = $317,731 )
2015	2015	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	6	1/28/2015	NON-COMPETING CONTINUATION	$317,731
														Subtotal = $317,731

Issue Date FY: 2014 ( Subtotal = $318,335 )
2014	2014	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	001	5	3/4/2014	NON-COMPETING CONTINUATION	$31,834
2014	2014	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	5	2/25/2014	NON-COMPETING CONTINUATION	$286,501
														Subtotal = $318,335

Issue Date FY: 2013 ( Subtotal = $332,068 )
2013	2013	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	001	4	3/20/2013	COMPETING CONTINUATION	$332,068
2013	2012	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	3	3/15/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $332,068

Issue Date FY: 2012 ( Subtotal = $213,047 )
2012	2012	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	3	1/26/2012	NON-COMPETING CONTINUATION	$213,047
														Subtotal = $213,047

Issue Date FY: 2011 ( Subtotal = $215,199 )
2011	2011	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	2	2/18/2011	NON-COMPETING CONTINUATION	$199,670
2011	2011	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	001	2	5/13/2011	NON-COMPETING CONTINUATION	$15,529
														Subtotal = $215,199

Issue Date FY: 2010 ( Subtotal = $259,605 )
2010	2010	GEORGIA TECH RESEARCH CORPORATION	HINMAN BUILDING	ATLANTA	GA	30332	FULTON	USA	Oral Diseases and Disorders Research	000	1	3/11/2010	NEW	$259,605
														Subtotal = $259,605

Grand Total All Awards = $4,463,904

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Patterning the Vertebrate Dentition Through Replacement and Repair

Award Number: R01DE019637

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2010

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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