Wednesday, May 28, 2025 5/28/2025

TRPC1, Calcium, and Saliva Secretion

Award Number: R01DE017102
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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TRPC1, Calcium, and Saliva Secretion - Project Summary Saliva is essential for several biological functions that are instrumental in maintaining oral health. It has been estimated that more than 5 million people in the US suffers from salivary gland dysfunction. Although saliva secretion is driven by concerted activities of several ion channels and transporters, the molecular mechanism involved in stimulated saliva secretion is not clearly understood. It has been suggested that Ca2+ plays a central role that regulates fluid secretion; however, information regarding the identity of the Ca2+ channels as well as the mechanism of regulation of these channels in salivary glands is not well understood. Moreover, in salivary gland dysfunction, such as primary Sjogren's syndrome (pSS) patients the acinar tissues appear to be normal but fail to function properly and have a decreased calcium response to agonist-stimulation. This observation raises the possibility that Ca2+ channels might be altered in this pathological condition. Results obtained from our awarded grant indicate that TRPC1 is the primary Ca2+ channel in salivary glands and is intimately involved saliva secretion. To understand the regulation of TRPC1 channel we have shown that TRPC1 is regulated through a complex protein-protein interaction. Furthermore, these interactions were confined to specific domains in the plasma membrane, but the protein that anchors these complexes is not clear. Therefore, in this renewal we intend to thoroughly characterize the role of cytosolic Ca2+ in salivary gland function and to determine the relationship between TRPC1 and salivary gland dysfunctions. The objective of this competitive renewal is to elucidate the Ca2+ signaling mechanism(s) in salivary gland dysfunction and establish the role of TRPC1 in pSS. This renewal application is based on the hypothesis that loss of TRPC1-mediated Ca2+ influx induces ER stress, promotes immune infiltration that leads to salivary gland destruction. The results of our studies are expected to provide new insights into the role of calcium channels and the molecular mechanism involved in salivary gland dysfunction as well as ways to restore functional salivary glands. Greater understanding of these events will be important in elucidating new therapy for salivary gland dysfunctions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $530,652 )
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	000	20	4/4/2025	NON-COMPETING CONTINUATION	$477,587
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	001	20	5/7/2025	NON-COMPETING CONTINUATION	$53,065
														Subtotal = $530,652

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	000	19	7/24/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $530,652 )
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	000	19	3/8/2023	NON-COMPETING CONTINUATION	$530,652
														Subtotal = $530,652

Issue Date FY: 2022 ( Subtotal = $525,345 )
2022	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	001	18	4/21/2022	NON-COMPETING CONTINUATION	$47,760
2022	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	000	18	2/18/2022	NON-COMPETING CONTINUATION	$477,585
														Subtotal = $525,345

Issue Date FY: 2021 ( Subtotal = $529,225 )
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	003	17	8/7/2021	COMPETING CONTINUATION	$269,917
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	001	17	2/19/2021	COMPETING CONTINUATION	$529,225
2021	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	000	16	2/12/2021	NON-COMPETING CONTINUATION	$0
2021	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	002	16	8/7/2021	NON-COMPETING CONTINUATION	-$269,917
														Subtotal = $529,225

Issue Date FY: 2019 ( Subtotal = $576,671 )
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	001	16	6/26/2019	NON-COMPETING CONTINUATION	$560,532
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	000	15	6/11/2019	SUPPLEMENT FOR EXPANSION	$16,139
														Subtotal = $576,671

Issue Date FY: 2018 ( Subtotal = $415,000 )
2018	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	004	15	8/15/2018	NON-COMPETING CONTINUATION	$381,250
2018	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	003	14	2/5/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$72,936
2018	2017	UNIVERSITY OF NORTH DAKOTA	264 CENTENNIAL DR	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	13	1/19/2018	NON-COMPETING CONTINUATION	-$347,500
2018	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Oral Diseases and Disorders Research	001	14	1/22/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$381,250
2018	2016	UNIVERSITY OF NORTH DAKOTA	264 CENTENNIAL DR	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	002	12	2/5/2018	NON-COMPETING CONTINUATION	-$72,936
														Subtotal = $415,000

Issue Date FY: 2017 ( Subtotal = $347,500 )
2017	2017	UNIVERSITY OF NORTH DAKOTA	264 CENTENNIAL DR	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	002	13	8/3/2017	NON-COMPETING CONTINUATION	$347,500
2017	2015	UNIVERSITY OF NORTH DAKOTA	264 CENTENNIAL DR	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	10	7/7/2017	NON-COMPETING CONTINUATION	-$38,969
2017	2015	UNIVERSITY OF NORTH DAKOTA	264 CENTENNIAL DR	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	001	11	7/7/2017	COMPETING CONTINUATION	$38,969
														Subtotal = $347,500

Issue Date FY: 2016 ( Subtotal = $347,500 )
2016	2016	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	12	8/29/2016	NON-COMPETING CONTINUATION	$347,500
														Subtotal = $347,500

Issue Date FY: 2015 ( Subtotal = $663,528 )
2015	2015	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	001	10	6/30/2015	NON-COMPETING CONTINUATION	$0
2015	2015	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	10	4/23/2015	NON-COMPETING CONTINUATION	$317,070
2015	2015	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	002	11	7/6/2015	COMPETING CONTINUATION	$346,458
														Subtotal = $663,528

Issue Date FY: 2014 ( Subtotal = $324,984 )
2014	2014	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	9	7/7/2014	NON-COMPETING CONTINUATION	$324,984
														Subtotal = $324,984

Issue Date FY: 2013 ( Subtotal = $319,360 )
2013	2013	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	8	5/20/2013	NON-COMPETING CONTINUATION	$319,360
														Subtotal = $319,360

Issue Date FY: 2012 ( Subtotal = $343,382 )
2012	2012	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	7	4/11/2012	NON-COMPETING CONTINUATION	$343,382
														Subtotal = $343,382

Issue Date FY: 2011 ( Subtotal = $357,801 )
2011	2011	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	001	6	6/7/2011	COMPETING CONTINUATION	$357,801
2011	2010	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	5	6/6/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $357,801

Issue Date FY: 2010 ( Subtotal = $232,260 )
2010	2010	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	5	4/15/2010	NON-COMPETING CONTINUATION	$232,260
														Subtotal = $232,260

Issue Date FY: 2009 ( Subtotal = $234,606 )
2009	2009	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	4	4/28/2009	NON-COMPETING CONTINUATION	$234,606
														Subtotal = $234,606

Issue Date FY: 2008 ( Subtotal = $234,606 )
2008	2008	UNIVERSITY OF NORTH DAKOTA	PO BOX 8356	GRAND FORKS	ND	58202	GRAND FORKS	USA	Oral Diseases and Disorders Research	000	3	4/24/2008	NON-COMPETING CONTINUATION	$234,606
														Subtotal = $234,606

Issue Date FY: 2007 ( Subtotal = $237,215 ) (Continued on the next page)
Grand Total All Awards = $6,994,587

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TRPC1, Calcium, and Saliva Secretion

Award Number: R01DE017102

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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