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ENGINEERING CRANIOFACIAL OSTEOGENESIS--MECHANICAL FORCES

Award Number: R01DE013964
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2000
PERIOD OF PERFORMANCE END DATE: 06/30/2005

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ENGINEERING CRANIOFACIAL OSTEOGENESIS--MECHANICAL FORCES - DESCRIPTION (ADAPTED FROM ABSTRACT) This proposal is multi-disciplinary and multi-institutional in nature and is one of the five components of a program submission on the rational design of the craniofacial complex from Pittsburgh researchers supported by the Pittsburgh Tissue Engineering Initiative. The present proposal has identified strategies to address a significant problem in craniofacial orthopedics and aims to determine a working range of parameters of biomechanical forces used to engineer osteogenesis in sutures and on periosteal surfaces of intramembranous bones. Improvement in understanding of engineering osteogenesis by biomechanical stimuli may provide a model of osteogenetic mechanisms different from those in long bones. Therefore, this application also targets one of NIAMS's interest areas of biomechanical induction of osteogenesis in intramembranous bones. The magnitude, mode and rate of in vivo bone strain will be quantified to determine what parameters can maximize craniofacial osteogenesis by means of bone strain measurements. Following chronic loading with selected force parameters, periosteal and sutural bone formation will be quantified by both atomic force microscopy and computer-assisted histomorphometric analysis with vital-stained bone specimens on the cortical bone surfaces and in craniofacial sutures. In vivo bone strain measurements will be quantified with a combined analysis of in vitro biomechanical properties of newly formed cortical and sutural bone tissues by atomic force microscopy. The proposed studies are anticipated not only to determine responses of craniofacial bones to selected parameters of biomechanical stimuli, but also to correlate mechanical stresses adjacent to craniofacial sutures with the amount of sutural bone formation, thus aiming to maximize both sutural and periosteal osteogenesis in craniofacial bones.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $235,135 )
2004	2004	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Oral Diseases and Disorders Research	000	5	8/18/2004	NON-COMPETING CONTINUATION	$235,135
														Subtotal = $235,135

Issue Date FY: 2003 ( Subtotal = $294,098 )
2003	2003	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Oral Diseases and Disorders Research	001	4	8/15/2003	SUPPLEMENT FOR EXPANSION	$65,810
2003	2003	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Oral Diseases and Disorders Research	000	4	6/27/2003	NON-COMPETING CONTINUATION	$228,288
														Subtotal = $294,098

Issue Date FY: 2002 ( Subtotal = $285,527 )
2002	2002	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Oral Diseases and Disorders Research	000	3	7/12/2002	NON-COMPETING CONTINUATION	$285,527
														Subtotal = $285,527

Issue Date FY: 2001 ( Subtotal = $279,816 )
2001	2001	UNIVERSITY OF ILLINOIS URBANA CAMPUS	809 SOUTH WRIGHT STREET	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Oral Diseases and Disorders Research	000	2	6/28/2001	NON-COMPETING CONTINUATION	$217,784
2001	2001	UNIVERSITY OF ILLINOIS URBANA CAMPUS	809 SOUTH WRIGHT STREET	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Oral Diseases and Disorders Research	001	2	7/27/2001	SUPPLEMENT FOR EXPANSION	$62,032
														Subtotal = $279,816

Issue Date FY: 2000 ( Subtotal = $244,959 )
2000	2000	UNIVERSITY OF ILLINOIS URBANA CAMPUS	809 SOUTH WRIGHT STREET	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Oral Diseases and Disorders Research	000	1	6/23/2000	NEW	$244,959
														Subtotal = $244,959

Grand Total All Awards = $1,339,535

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ENGINEERING CRANIOFACIAL OSTEOGENESIS--MECHANICAL FORCES

Award Number: R01DE013964

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2000

PERIOD OF PERFORMANCE END DATE: 06/30/2005

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