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IMPROVEMENT OF PREVENTIVE AND RESTORATIVE MATERIALS

Award Number: R01DE005129
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/1977
PERIOD OF PERFORMANCE END DATE: 06/30/2008

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IMPROVEMENT OF PREVENTIVE AND RESTORATIVE MATERIALS - DESCRIPTION: The objectives focus on the development of improved materials to enable Dentists to bond Dental resins and composites more strongly and durably to dentin and enamel surfaces. Bonding to enamel has been quite successful clinically, following the pioneering efforts of Dr. Michael Buonocore many years ago. With dentin surfaces, however, there remains the need for improvements beyond those that have been incrementally made over the decades. Success in this would benefit many millions of people. Currently, "total-etch" bonding procedures are used to remove structurally limited material from the surfaces of dentin and enamel before bonding agents are applied. This etching procedure results in hydrated micropores on enamel surfaces and exposure of a thin layer of strongly attached demineralized collagen fibrils on dentin surfaces. These hydrated fibrils consist mostly of assemblies of Type I collagen molecules having covalent cross-links connecting their telopeptide ends with helical regions of neighboring molecules. Three-dimensional computer modeling of neighboring segments of demineralized collagen fibrils indicates that their receptor sites have extremely complex chemical diversity and spatial configurations accessible for the "docking" of bonding agents. It follows that if complex co-polymerizable molecules can be prepared having multiple ligand groups having the same spatial dimensions as complimentary receptor sites on collagen, then the competition with water molecules and the anchoring of such molecules would be much better than that obtainable with more simple primers. Therefore, bonding formulations should contain monomers having combinations and permutations of a sufficient number of hydrophilic polar ligand groups to render them soluble in the interfibrillar water of hydration and also contain co-polymerizable groups on each of the molecules. Improved polymerizable cyclodextrin derivatives (PCDs) will be synthesized with advanced synthetic protocols whereby the ligand and co-polymerizable groups are attached to the cyclodextrin with hydrolytically stable ether connections. MALDI-TOF MS, TLC, LC-MS, FTIR, NMR, and other analytical methods will characterize acceptable families of PCDs that will be formulated with compatible diluent co-monomers. Evaluation tests will include relative affinities of PCDs and control primers to demineralized dentin, measured with a previously developed surface-activity test method, and adhesive bonding to dentin and enamel surfaces.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $236,453 )
2007	2007	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	28	6/21/2007	NON-COMPETING CONTINUATION	$236,453
														Subtotal = $236,453

Issue Date FY: 2006 ( Subtotal = $243,515 )
2006	2006	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	27	5/18/2006	NON-COMPETING CONTINUATION	$243,515
														Subtotal = $243,515

Issue Date FY: 2005 ( Subtotal = $249,375 )
2005	2005	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	26	7/7/2005	COMPETING CONTINUATION	$249,375
														Subtotal = $249,375

Issue Date FY: 2003 ( Subtotal = $266,385 )
2003	2003	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	25		NON-COMPETING CONTINUATION	$266,385
														Subtotal = $266,385

Issue Date FY: 2002 ( Subtotal = $258,623 )
2002	2002	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	24	3/1/2002	NON-COMPETING CONTINUATION	$258,623
														Subtotal = $258,623

Issue Date FY: 2001 ( Subtotal = $251,092 )
2001	2001	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	23	3/15/2001	NON-COMPETING CONTINUATION	$251,092
														Subtotal = $251,092

Issue Date FY: 2000 ( Subtotal = $243,779 )
2000	2000	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	22	5/5/2000	NON-COMPETING CONTINUATION	$243,779
														Subtotal = $243,779

Issue Date FY: 1999 ( Subtotal = $210,958 )
1999	1999	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	21	3/19/1999	COMPETING CONTINUATION	$210,958
														Subtotal = $210,958

Grand Total All Awards = $1,960,180

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IMPROVEMENT OF PREVENTIVE AND RESTORATIVE MATERIALS

Award Number: R01DE005129

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/1977

PERIOD OF PERFORMANCE END DATE: 06/30/2008

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