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Interhemispheric cortico-bulbar connectivity in the olfactory system

Award Number: R01DC022556
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/07/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Interhemispheric cortico-bulbar connectivity in the olfactory system - Project Summary To reliably interpret information about the environment, animals must integrate sensory information from lateralized sensory organs. In the olfactory system of most animals, despite a single nose, each nostril operates as an independent sensor. Among the sensory modalities, the olfactory system is unique for its relatively conserved lateralization, with the first hemispheric crossing occurring within the cortex at the anterior olfactory nucleus. The anterior olfactory nucleus also sends dense feedback projections to both olfactory bulbs, which may help align neuronal ensembles that drive odor perception. Yet, the sensory information encoded by these projections, how they shape the activity profiles of neurons in the olfactory bulb, and their role in sensory processing are not well understood. Our approach will provide a detailed analysis of the connectivity and information broadcast between cortical axons and their postsynaptic targets in both olfactory bulb hemispheres. We will test the hypothesis that the stability of interhemispheric sensory coding is dependent on the ipsilateral and contralateral projections from the AON to both olfactory hemispheres. Aim 1 will characterize the synaptic and molecular architecture of interhemispheric projections from the anterior olfactory nucleus to the olfactory bulb. Aim 2 will determine how interhemispheric projections shape the activity profiles of olfactory bulb output neurons. Finally, Aim 3 will define the sensory representations and bilateral alignment of the information broadcast from the anterior olfactory nucleus to the olfactory bulb. The experiments and analyses we propose here will provide novel insight into the mechanism by which the two hemispheres of the brain coordinate robust and efficient sensory coding. The outcomes of our studies will be generally applicable to all sensory modalities by providing foundational information on how the brain integrates and processes lateralized sensory information.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $553,108 )
2026	2026	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Research Related to Deafness and Communication Disorders	000	1	5/12/2026	NEW	$553,108
														Subtotal = $553,108

Grand Total All Awards = $553,108

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Interhemispheric cortico-bulbar connectivity in the olfactory system

Award Number: R01DC022556

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/07/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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