Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndrome

Award Number: R01DC021711
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2030

Group Awards By:

View Award Description

Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndrome - PROJECT SUMMARY Deficits in speech production are highly prevalent in neurodevelopmental disorders (NDDs). They are some of the most debilitating of all deficits because they impair communication and there are not effective and efficient substitutes for speaking. In order to build our mechanistic understanding of the neurodevelopmental causes of speech impairments, we propose to study speech dysfunction in individuals with 16p11.2 deletions, which is one of the most common genetic etiologies of autism and is associated with related conditions such as epilepsy, motor impairment, sensory dysfunction, and most prominently, speech impairments, which affect an estimated 70-100% of individuals with this copy number variant. We will capitalize on data being collected for the ongoing UCSF Speech, Voice, and Communication (SVAC) study of speech in individuals with idiopathic autism for comparison groups, including speech-impaired autistic and typically developing participants, for the proposed cross-sectional study. We will enroll participants with 16p11.2 deletion syndrome and concurrently examine speech abilities, sensorimotor control of speech, and the neural processes that support these functions. This will allow us to build a mechanistic understanding of the potential causes of speech impairments in these populations. Our strong preliminary data suggest distinct mechanisms of impairment in speech-impaired individuals with autism without known genetic etiology and individuals with 16p11.2 deletion syndrome. Contrasting the more genetically and phenotypically homogenous group of individuals with 16p11.2 deletions with the more heterogeneous autism group will allow us to identify differences in neurobiology and sensorimotor control of speech that are specific to genetic impact via the deletion as opposed to being associated with broad neurodevelopmental differences. Thus, the proposed work will build our neurobiological and mechanistic understanding of speech impairments in neurodevelopmental disorders. This knowledge can be applied to uncover potential causal pathways of speech impairments and identify novel targets for intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $696,611 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	001	2	2/11/2026	NON-COMPETING CONTINUATION	$69,660
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	2	1/13/2026	NON-COMPETING CONTINUATION	$626,951
														Subtotal = $696,611

Issue Date FY: 2025 ( Subtotal = $696,836 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	1	1/23/2025	NEW	$696,836
														Subtotal = $696,836

Grand Total All Awards = $1,393,447

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndrome

Award Number: R01DC021711

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer