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Electrophysiological representations of odor in the human brain

Award Number: R01DC021663
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Electrophysiological representations of odor in the human brain - Olfactory perception relies on the brain’s ability to extract and represent different features of an odor stimulus. For example, stimulus intensity and identity are fundamental stimulus features that must be segmented for accurate perception; the same odor can be encountered in the environment at different strengths. Rodent work has identified a number of neural correlates of odor concentration and chemical structure, but it remains unclear how these representations relate to perceptual intensity and identity. A major gap in our understanding of odor perception is the missing link between direct perceptual ratings (easily obtainable in humans) and neural responses (much easier to obtain in rodents). Research proposed here aims to determine how odor intensity and identity are presented in human brain, both in human piriform cortex and across distinct networks defined by low and high frequency oscillations. We will accomplish these aims using direct invasive recordings of neural activity from human olfactory cortex, while single-trial perceptual ratings are collected. Our findings will reveal how odor features are represented in the human brain, contributing fundamental basic understanding of the olfactory system. Olfactory brain areas are implicated in neurodegenerative diseases such as Alzheimer’s Disease, Parkinson’s Disease and epilepsy. Increased understanding of coding mechanisms in these areas, and interactions between these areas and the rest of the brain may lead to better understanding of the mechanisms of diseases that involve olfactory cortical areas.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $596,097 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	2	1/28/2025	NON-COMPETING CONTINUATION	$596,097
														Subtotal = $596,097

Issue Date FY: 2024 ( Subtotal = $680,384 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	1	2/15/2024	NEW	$680,384
														Subtotal = $680,384

Grand Total All Awards = $1,276,481

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Electrophysiological representations of odor in the human brain

Award Number: R01DC021663

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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