Saturday, December 13, 2025 12/13/2025

Mechanisms of voice disorders associated with vocal fold atrophy

Award Number: R01DC021453
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2028

Group Awards By:

View Award Description

Mechanisms of voice disorders associated with vocal fold atrophy - ABSTRACT Clinically, atrophy of the intrinsic laryngeal musculature is poorly defined likely related to limited understanding of fundamental biological processes underlying this complex, aberrant tissue phenotype. This lack of insight underlies suboptimal therapeutic strategies for these challenging patients. In addition to fundamental investigation regarding this phenotype, we hypothesize that initiation and maintenance of atrophy of the intrinsic laryngeal musculature is related to signaling events in the mucosa. Specifically, our laboratory elucidated the role of TGF-β signaling with an emphasis on therapeutic strategies targeting the SMAD family of signaling proteins in the vocal fold lamina propria. SMADs, however, also mediate muscle atrophy in other systems, specifically through regulation of atrogenes and myostatin, a member of the TGF-β superfamily. We hypothesize that the inherent response to injury in the lamina propria elicits and/or enhances an atrophic in the muscle. This concept is inherently innovative in that it refutes clinical dogma suggesting the vocal fold mucosa and muscle of the vocal folds operate as wholly separate and distinct entities. In that regard, we propose to interrogate fundamental and functional laryngeal muscle outcomes of recurrent laryngeal nerve injury-mediated thyroarytenoid atrophy in the context of both acute and chronic mucosal injury. In addition, we seek to interrogate key biochemical relationships and interactions between multiple cell types from the vocal folds to provide foundational insight into processes underling atrophy. And finally, we seek to provide preliminary data related to therapeutic strategies to prevent/treat laryngeal muscle atrophy targeting SMAD signaling. Ultimately, these data represent substantive contributions to the literature and are foundational for the development of novel treatment strategies for millions of patients with disability related to voice disorders and laryngeal disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $456,401 )
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	3	11/28/2025	NON-COMPETING CONTINUATION	$456,401
														Subtotal = $456,401

Issue Date FY: 2025 ( Subtotal = $484,006 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	2	4/26/2025	NON-COMPETING CONTINUATION	$48,401
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	2	11/14/2024	NON-COMPETING CONTINUATION	$435,605
														Subtotal = $484,006

Issue Date FY: 2024 ( Subtotal = $455,694 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	1	12/14/2023	NEW	$455,694
														Subtotal = $455,694

Grand Total All Awards = $1,396,101

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mechanisms of voice disorders associated with vocal fold atrophy

Award Number: R01DC021453

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer