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Circuit functions of fast-spiking interneurons in the main olfactory bulb

Award Number: R01DC021296
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Circuit functions of fast-spiking interneurons in the main olfactory bulb - PROJECT SUMMARY/ABSTRACT The olfactory system is critical to several aspects of behavior and survival in mammals, including humans. The olfactory bulb is the first processing station of the olfactory system and constitutes an exceptional model system for the study of neural coding, capable of encoding a highly complex sensory space within a compact and well- organized structure. Understanding local circuit computation within the olfactory bulb will thus provide key insight into fundamental principles of brain function. Broad perturbation of synaptic inhibition within the olfactory bulb significantly disrupts projection mitral/tufted cell synchronization and olfactory-guided behavior, underscoring a central role of inhibitory interneurons in local circuit computation. In contrast to other regions of the brain such as neocortex and hippocampus, however, fundamental understanding of how the diverse inhibitory interneurons within the olfactory bulb specifically support neural coding has remained elusive, with detailed knowledge of how unitary synaptic interactions contribute to the precise regulation of mitral/tufted cell spike timing in particular lacking. To advance understanding of local circuit computation and neural coding in the olfactory bulb, this project will therefore directly examine unitary synaptic interactions between mitral/tufted cells and a highly-conserved but understudied class of fast-spiking interneurons, using whole-cell pair recordings in acute mouse brain slices together with pharmacology, morphological reconstruction, immunostaining, and simulations. Investigation will specifically address three aims: 1) determine how fast-spiking interneurons regulate mitral/tufted cell spike timing, 2) determine how dendritic computation supports fast-spiking interneuron function, and 3) determine how fast-spiking interneuron signaling adapts with neural activity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $402,500 )
2025	2025	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Research Related to Deafness and Communication Disorders	000	3	6/5/2025	NON-COMPETING CONTINUATION	$402,500
														Subtotal = $402,500

Issue Date FY: 2024 ( Subtotal = $369,488 )
2024	2024	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Research Related to Deafness and Communication Disorders	000	2	7/1/2024	NON-COMPETING CONTINUATION	$369,488
														Subtotal = $369,488

Issue Date FY: 2023 ( Subtotal = $366,737 )
2023	2023	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Research Related to Deafness and Communication Disorders	000	1	6/30/2023	NEW	$366,737
														Subtotal = $366,737

Grand Total All Awards = $1,138,725

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Circuit functions of fast-spiking interneurons in the main olfactory bulb

Award Number: R01DC021296

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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