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Improving Reading Competence in Aphasia with Combined Aerobic Exercise and Phono-Motor Treatment

Award Number: R01DC021063
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Improving Reading Competence in Aphasia with Combined Aerobic Exercise and Phono-Motor Treatment - Close to 2.5 million Americans are currently living with post-stroke aphasia, a debilitating communication disorder affecting multiple language modalities. Most stroke survivors with aphasia have acquired reading deficits, which persist chronically and severely limit life participation and autonomy. There is an urgent need for effective treatments grounded in stroke neurobiology which yield robust functional improvements. Treatments targeting impaired reading processes and aimed at restoring cerebral blood flow (CBF) can meet this need by directly remediating dysfunctional brain mechanisms. In the proposed R01 we will combine aerobic exercise training (AET) with an intensive phono-motor reading treatment (PMT). Our central hypothesis is that a single bout of aerobic exercise will increase CBF and oxygenation, and if delivered before a PMT session, will facilitate treatment-induced neuroplasticity, strengthening damaged phonological networks and leading to robust functional improvements over time. We and others found that reduced CBF in parts of the left hemisphere outside the stroke lesion persists for weeks to months after a stroke and predicts more severe language deficits and worse recovery. Phonological processing, or the ability to derive sound structure of words, critical to so many language modalities, is consistently impaired in left-hemisphere stroke survivors with aphasia and reding deficits. We expect that the proposed treatment targeting both the impaired CBF, and phonological deficits will markedly increase treatment effectiveness and enhance generalization to untrained language modalities. We will test our central hypothesis by pursuing three specific aims. Under Aim 1, we will determine if combined AET and PMT improve language outcomes by carrying out a randomized controlled trial in 70 individuals with chronic left- hemisphere stroke. Participants will complete either 20 minutes of moderate aerobic exercise or light stretching prior to each session of intensive PMT. We expect that while both groups should improve, the AET group will show more robust language improvements after 40 sessions of combined AET+PMT. Under Aims 2-3, we will study both the immediate and sustained impact of AET and PMT on brain function using 3 MRI scans, administered before the intervention, after the initial aerobic exercise session, and after the full course of AET + PMT treatment. We expect that aerobic exercise will have an immediate positive impact on CBF and resting state functional connectivity, as well as induce a sustained improvement in these measures and in task-related brain activity compared to the pre-intervention baseline. While each of these interventions in isolation has shown positive impact on stroke recovery, the proposed project will test if AET promotes acquisition and retention of therapy skills when adjuvant to PMT. This has the potential to radically change how these treatments are applied, increasing their effectiveness, and ultimately improving the lives of 2.5 million Americans living with stroke- related aphasia. In addition, it is likely that the results will contribute to the understanding of stroke recovery mechanisms thereby fundamentally advancing the field of neurorehabilitation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $421,468 )
2026	2026	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	000	3	2/12/2026	NON-COMPETING CONTINUATION	$421,468
														Subtotal = $421,468

Issue Date FY: 2025 ( Subtotal = $423,572 )
2025	2025	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	001	2	5/20/2025	NON-COMPETING CONTINUATION	$42,357
2025	2025	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	000	2	2/14/2025	NON-COMPETING CONTINUATION	$381,215
														Subtotal = $423,572

Issue Date FY: 2024 ( Subtotal = $419,355 )
2024	2024	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	002	1	4/23/2024	NEW	$419,355
2024	2024	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	000	1	3/1/2024	NEW	$419,355
2024	2024	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	001	1	4/3/2024	NEW	-$419,355
														Subtotal = $419,355

Grand Total All Awards = $1,264,395

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Improving Reading Competence in Aphasia with Combined Aerobic Exercise and Phono-Motor Treatment

Award Number: R01DC021063

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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