Wednesday, August 20, 2025 8/20/2025

Next Generation OAEs

Award Number: R01DC020962
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Next Generation OAEs - Project Summary/Abstract Distortion product otoacoustic emissions (DPOAE) are grossly underutilized in clinical applications. Yet the need for early and accurate diagnosis as well as monitoring of new therapies is growing and will demand more precise diagnostic tools. This proposal lays the foundation for assimilating advanced DPOAE diagnostics into clinical practice. Specifically, the first aim will validate the test performance of a new protocol for recording DP-Grams. This protocol will use frequency-specific stimulus conditions that are matched to local properties of the cochlea with the goal of better detection of mild-to-moderate hearing loss. The second aim will utilize DPOAE growth functions to detect early changes in the cochlea due to aging and differentiate these effects from those induced by over-exposure to noise. The third aim will use an innovative expansion of DPOAEs to objectively estimate cochlear tuning. The proposal will create a two-dimensional joint metric of tuning and DPOAE strength, which will help to identify hearing-related declines beyond mere changes in sensitivity. The proposed work also serves the critical need to extend the frequency bandwidth of all DPOAE applications to the highest frequencies of human hearing. This is made possible by incorporating modern calibration and signal delivery/recording techniques – developed in part by the laboratories of both PIs – into all experiments. The proposed experiments are built on previous peer-reviewed and published work from the two participating laboratories. Taken together, the proposed experiments are critical next steps necessary to move DPOAEs from a screening tool to potent clinical probe that serves the next generation of diagnostic and monitoring needs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $650,163 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	001	2	7/4/2025	NON-COMPETING CONTINUATION	$650,163
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	1	10/9/2024	NEW	$0
														Subtotal = $650,163

Issue Date FY: 2024 ( Subtotal = $656,723 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	1	8/30/2024	NEW	$656,723
														Subtotal = $656,723

Grand Total All Awards = $1,306,886

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Next Generation OAEs

Award Number: R01DC020962

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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