Sunday, July 6, 2025 7/6/2025

Diversification of the mechanotransduction complex in vestibular hair cells

Award Number: R01DC020879
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/14/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

Group Awards By:

View Award Description

Diversification of the mechanotransduction complex in vestibular hair cells - Abstract The vestibular system utilizes specialized hair cells for sensing gravity and head motions. Vestibular hair cells have been broadly characterized into two cell types: Type I and Type II. Clear differences also exist among the zones of vestibular organs, consisting of a central zone surrounded by a peripheral zone of hair cells. How the mechanotransduction machinery varies across these two cell types or zones is poorly understood. Existing evidence suggests that the striolar (central) versus extrastriolar (peripheral) zones serve different functions such as sensing high versus low frequencies. How these functional differences are achieved at the molecular level is not clear. The aim of this proposal is to characterize the mechanotransduction complex in the different hair cells and zones of the utricle, a vestibular organ that is vital for sensing gravity and head motions. We have preliminary data that demonstrate differential expression of transcripts encoding a key component of the mechanotransduction complex: transmembrane channel-like proteins (TMC1 and TMC2). In zebrafish and the mouse, both Tmc1 and Tmc2 genes are expressed in regional gradients that correlate with the striolar and extrastriolar zones of the utricle. We aim to determine the dynamic developmental and adult patterns of Tmc1/2 expression along with other members of the mechanotransduction complex. We also intend to correlate these expression patterns with hair bundle morphology and hair cell physiology. In addition, we will examine these features of TMC expression and other components of the mechanotransduction complex in human utricular hair cells. Determining the extent of conservation of these features among species will be essential for the interpretation of animal models and how they inform approaches to regeneration of vestibular hair cells or other therapeutic methods for vestibular dysfunction in human patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $642,743 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	3	6/25/2025	NON-COMPETING CONTINUATION	$642,743
														Subtotal = $642,743

Issue Date FY: 2024 ( Subtotal = $650,253 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	2	6/13/2024	NON-COMPETING CONTINUATION	$650,253
														Subtotal = $650,253

Issue Date FY: 2023 ( Subtotal = $659,041 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	1	7/12/2023	NEW	$659,041
														Subtotal = $659,041

Grand Total All Awards = $1,952,037

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Diversification of the mechanotransduction complex in vestibular hair cells

Award Number: R01DC020879

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/14/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer