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Advancing primate models of human auditory cognitive control

Award Number: R01DC020749
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Advancing primate models of human auditory cognitive control - Abstract The development of more powerful primate models of auditory cognitive control is critical for advancing understanding of the cognitive and neural systems underlying the capacity for human communication. Valid models depend on identification of which aspects of these systems are present in monkeys. The long-term goal of this work is to better understand the relations between auditory cognitive control in humans and primates, enhancing the utility of primate models for research on auditory-communicative disorders. The overall objective of this application is to identify some aspects of auditory cognitive control in humans that can be modeled in primates. The central working hypothesis is that the same experimental techniques used to establish visual cognitive control can also elucidate components of auditory cognitive control. The rationale is that valid behavioral models of auditory cognitive control in primates are foundational for studies of the relevant neural systems, and ultimately for developing and testing novel treatments for individuals with communication disorders. The central hypothesis will be tested by accomplishing three specific aims: (1) Use tests that are diagnostic of working memory to determine which components of human auditory working memory can be modeled in rhesus monkeys, (2) Assess cognitive control of auditory attention and decision-making in monkeys, and (3) Evaluate a putative neural substrate of auditory cognitive control using comparative studies across humans, orangutans, and monkeys. For the first aim, whether monkeys engage in active maintenance of information in auditory working memory will be tested using competing cognitive load and directed forgetting manipulations in auditory memory tests. For the second aim, control of auditory attention will be evaluated using tasks that require flexibly focusing auditory attention and filtering auditory distractors. Cognitive control of decision-making will be evaluated using tests of adaptive information-seeking. For the third aim, auditory cognitive abilities will be compared across monkeys, orangutans, and humans to evaluate the putative correlation between these skills and expansion of the dorsal auditory pathway. The proposed research is innovative because it uses novel tests of auditory working memory, attentional control, and adaptive decision-making that specifically dissociate these processes from non-controlled, passive, or automatic mechanisms. The work also achieves a systematic comparison of auditory memory across primates using equivalent tests. The proposed research is significant because it is expected to provide a robust foundation for future biomedical research on auditory-communicative deficits using proven primate models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $450,613 )
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	001	3	5/6/2025	NON-COMPETING CONTINUATION	$45,061
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	3	12/17/2024	NON-COMPETING CONTINUATION	$405,552
														Subtotal = $450,613

Issue Date FY: 2024 ( Subtotal = $451,013 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	2	1/3/2024	NON-COMPETING CONTINUATION	$405,912
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	001	2	5/2/2024	NON-COMPETING CONTINUATION	$45,101
														Subtotal = $451,013

Issue Date FY: 2023 ( Subtotal = $451,375 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	1	12/21/2022	NEW	$451,375
														Subtotal = $451,375

Grand Total All Awards = $1,353,001

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Advancing primate models of human auditory cognitive control

Award Number: R01DC020749

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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