Monday, June 30, 2025 6/30/2025

Understanding functional transformations carried out by the bulb

Award Number: R01DC020519
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Understanding functional transformations carried out by the bulb - Project Summary/Abstract Compromised olfactory function is associated with the aging process, as well as a number of human diseases. Our incomplete understanding of the brain makes it challenging to comprehend the mechanisms that underlie these sensory deficits and other psychiatric disorders. Understanding how sensory information is encoded and transformed by neural circuits will help define the basic mechanisms that underlie these challenges. For many animals, smell is critical for recognizing and locating food, mates and dangers. Odor recognition requires the identification of a specific smell that can vary in intensity, while localization involves detecting a concentration profile that varies in time and space. Both processes must be carried out while the stimulus is embedded in a complex chemical context. This requires that the olfactory system recognize and maintain a concentration- invariant representation of the odor, while detecting its changing concentration gradient and segmenting its percept from other chemical stimuli present in the environment. Understanding how the brain carries out these processes is key to understanding perceptual stability. The goal of this proposal is to define the neural circuits that support odor recognition and the ability to adjust sensitivity to complex olfactory scenes in vivo. First, we will define how changes in odor concentration are encoded and transformed across the olfactory bulb circuit. Next, we will examine how different concentrations or durations of odor exposure impact olfactory bulb responses to future odor stimulation. We will then test the hypothesis that olfactory bulb adaptation underlies dynamic range adjustments involved in maintaining sensitivity in different odor backgrounds. This proposal will answer these questions using an imaging approach to measure the neural activity from the olfactory receptor neuron input, and the mitral/tufted cell output that innervate olfactory bulb glomeruli. We will pair this strategy with a mechanistic toolkit to dissect the underlying mechanisms that drive functional transformations in the bulb. The impact of this proposal will be to generate a comprehensive mechanistic description of how two perceptual functions are carried out by the olfactory bulb, which are the critical first steps that will ultimately link physiology with naturalistic behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $377,835 )
2025	2025	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Research Related to Deafness and Communication Disorders	000	4	4/25/2025	NON-COMPETING CONTINUATION	$377,835
														Subtotal = $377,835

Issue Date FY: 2024 ( Subtotal = $377,835 )
2024	2024	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Research Related to Deafness and Communication Disorders	000	3	6/6/2024	NON-COMPETING CONTINUATION	$377,835
														Subtotal = $377,835

Issue Date FY: 2023 ( Subtotal = $377,835 )
2023	2023	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Research Related to Deafness and Communication Disorders	000	2	5/16/2023	NON-COMPETING CONTINUATION	$377,835
														Subtotal = $377,835

Issue Date FY: 2022 ( Subtotal = $400,958 )
2022	2022	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Research Related to Deafness and Communication Disorders	000	1	6/27/2022	NEW	$400,958
														Subtotal = $400,958

Grand Total All Awards = $1,534,463

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Understanding functional transformations carried out by the bulb

Award Number: R01DC020519

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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