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Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees

Award Number: R01DC020316
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees - This research aims to understand age-related temporal processing in older cochlear-implant (CI) users. The gap in knowledge is that critical measurements and comparisons have been unavailable to disentangle peripheral from central factors that impact CI performance. The long-term goals of this grant are to (1) understand the biological effects of auditory aging and (2) determine how to best remediate age-related auditory deficits with a CI. The overall objective of this application, which is the next step toward attainment of our long-term goals, is to disentangle the peripheral and central contributions to age-related temporal processing deficits in CI users. Our central hypothesis is that age-related speech perception deficits are explained by unique contributions from pe- ripheral and central auditory functions, which significantly affect outcomes in older CI users. The rationale is that CIs are uniquely suited to disentangle peripheral vs central contributions of age-related temporal processing deficits because they can bypass or easily characterize peripheral contributions to hearing, making an ideal system for auditory aging research. We plan to test our central hypothesis by pursuing the following specific aims: (1) Determine the extent to which temporal processing from single-electrode stimulation can be explained by aging and the peripheral electrode-to-neural interface in CI subjects; (2) Determine the extent to which speech perception can be explained by aging and the peripheral electrode-to-neural interface in CI subjects; (3) Deter- mine the extent and manner in which central auditory compensation overcomes peripheral processing deficits that contribute to age-related performance declines in CI subjects. These aims will yield the following expected outcomes. First, we will understand how aging and ENI correlate with each other, and how well peripheral con- tributions explain simple single-electrode temporal-processing performance. Second, we will understand if pe- ripheral contributions play a smaller role in explaining speech perception performance using multi-electrode stim- ulation, relative to perception of simple signals presented to single electrodes. Third, we will ascertain if age- related central processing deficits contribute above and beyond the peripheral deficits for processing of both simple and complex acoustic signals (including speech) among CI listeners. The proposed research is significant because expanding our understanding of the locus of the age-related temporal processing deficits will help de- velop age-specific guidance to CI candidacy, approaches to CI programming, and CI rehabilitation, improving an older CI user’s performance and quality of life. The proposed research is innovative because CIs offer a unique ability to bypass and characterize the periphery, allowing us to disentangle peripheral vs central mecha- nisms that contribute to age-related hearing deficits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $450,849 )
2025	2025	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BUILDING	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Research Related to Deafness and Communication Disorders	000	9	3/29/2025	NON-COMPETING CONTINUATION	$450,849
														Subtotal = $450,849

Issue Date FY: 2024 ( Subtotal = $541,641 )
2024	2024	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BUILDING	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Research Related to Deafness and Communication Disorders	002	8	5/30/2024	NON-COMPETING CONTINUATION	$541,641
2024	2023	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BUILDING	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Research Related to Deafness and Communication Disorders	001	7	5/24/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BUILDING	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Research Related to Deafness and Communication Disorders	000	7	3/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $541,641

Issue Date FY: 2023 ( Subtotal = $560,679 )
2023	2023	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BLDG 7809 REGENTS DR	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Research Related to Deafness and Communication Disorders	000	7	3/22/2023	NON-COMPETING CONTINUATION	$560,679
														Subtotal = $560,679

Issue Date FY: 2022 ( Subtotal = $562,977 )
2022	2022	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BLDG 7809 REGENTS DR	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Research Related to Deafness and Communication Disorders	000	6	3/25/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$562,977
2022	2022	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BLDG 7809 REGENTS DR	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Research Related to Deafness and Communication Disorders	002	6	5/27/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$562,977
2022	2022	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BLDG 7809 REGENTS DR	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Research Related to Deafness and Communication Disorders	001	6	5/23/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$562,977
														Subtotal = $562,977

Grand Total All Awards = $2,116,146

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Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees

Award Number: R01DC020316

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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