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Dynamic circuit motifs underlying multimodal interactions in primate auditory cortex

Award Number: R01DC019979
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Dynamic circuit motifs underlying multimodal interactions in primate auditory cortex - ABSTRACT There is a strong movement within the neuroscience community towards studying the brain under naturalistic conditions, in rich multisensory paradigms and in the context of behaviors observed in natural environments, such as free viewing. This requires transforming our traditional data collection and analysis pipelines, and their underlying theoretical frameworks. Instead of focusing on one specific system supporting a particular brain function, we must conduct multisite recordings targeting multiple, reciprocally connected circuits, which is the main motivation for our project. Fortunately, this is now technically feasible in both human and nonhuman primates. The overarching goal of our project is to define information transmitting (“driving”) vs. “modulatory” circuits of the auditory system. The rationale for this goal is that if only driving circuits existed in the brain, we would not have the ability to focus on behaviorally relevant aspects of our environment. From this perspective, modulatory circuits play as an important role in brain operations as information transmitting ones. Specifically, our project will explore the interaction of four domains of brain function and the distinctive, dynamic circuit motifs (circuits and their spectrotemporal neuronal activity patterns) that underlie them. These brain functions are auditory perception, multisensory interactions within the auditory system, motor sampling of the environment (eye movements), and memory recall. We will utilize electrophysiological recordings during behavioral experiments in non-human and human primates, with computational modeling to bridge the gap between different recording scales (single unit to EEG), and species (non-human primate vs. human). Computational models will also be used to suggest specific target nodes and patterns of the distinct circuits for neuromodulation. Using the spectrotemporal neuronal activity (a key feature of a dynamic circuit motif) and model prediction based intracranial electrical brain stimulation, we will verify each identified circuit’s causal role in producing its unique circuit motifs and in supporting different aspects of behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $652,137 )
2025	2025	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD BLDG 35	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	4	7/11/2025	NON-COMPETING CONTINUATION	$652,137
														Subtotal = $652,137

Issue Date FY: 2024 ( Subtotal = $668,437 )
2024	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD BLDG 35	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	3	6/26/2024	NON-COMPETING CONTINUATION	$668,437
														Subtotal = $668,437

Issue Date FY: 2023 ( Subtotal = $682,570 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	001	2	6/22/2023	NON-COMPETING CONTINUATION	$682,570
2023	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	1	3/9/2023	NEW	$0
														Subtotal = $682,570

Issue Date FY: 2022 ( Subtotal = $698,203 )
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	001	1	9/20/2022	NEW	$0
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	1	9/16/2022	NEW	$698,203
														Subtotal = $698,203

Grand Total All Awards = $2,701,347

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Dynamic circuit motifs underlying multimodal interactions in primate auditory cortex

Award Number: R01DC019979

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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