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Caregiver Speech and Brain-Behavior Development in Infants At-Risk for ASD

Award Number: R01DC019660
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/20/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Caregiver Speech and Brain-Behavior Development in Infants At-Risk for ASD - PROJECT SUMMARY Caregiver Speech and Brain-Behavior Development in Infants At-Risk for Autism Spectrum Disorder The defining symptoms of autism spectrum disorder emerge only after an initial presymptomatic period during the first year of life. The first year of life is also a time of tremendous growth and neuroplasticity for the infant brain. The overall goal of the proposed longitudinal study is to enable and inform presymptomatic infant interventions for autism by examining the relationships between infant vocalizations, caregiver speech, and brain-behavior development in infants at high familial risk for autism. Conceptually, the project focuses on the potential protective effects of caregiver speech on infant development. The proposed study is a companion to and collaboration with the IBIS Network-Early Prediction Study, an NIH-sponsored study of 250 infants at high familial risk for autism. All infants in the study have an older sibling with autism. These high-risk infants have a 20% probability of developing autism themselves. Ecologically valid day-long home language recordings will be collected when infants are 6 and 12 months of age. A state-of-the-art automated processing pipeline will used to estimate daily counts of infant and caregiver speech quality and quantity. Micro-level targeted annotation will be applied to semi-structured, parent-infant play sessions collected in the lab. Automated processing pipelines and micro-level targeted annotation will be used to generate multivariate infant vocalizations and caregiver speech data. Infant vocalizations will be classified as speech-like or non-speech-like (delight or distress). Caregiver speech variables include lexical diversity, mean length utterance, and temporal contingency. The study will determine if infant vocalizations predict subsequent autism diagnosis and later language and social communication scores, and specify the relationship between caregiver speech and infant communication skills. Diffusion MRI will be collected when infants are 6, 12, and 24 months of age by the Early Prediction Study. The proposed study will determine if multivariate caregiver speech is related to targeted prefrontal and temporal brain regions. By determining if caregiver speech can have a protective effect on brain development, we forge a new scientific approach to studying communication development in infants at high-risk for autism. As first-year autism detection and presymptomatic intervention become increasingly feasible, an evidence base is needed to inform interventions. The proposed study will identify infant-based language and communication risk markers, caregiver-based intervention targets, and brain-based monitoring biomarkers to guide presymptomatic intervention for autism that is parent-mediated and delivered in the natural setting.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $716,811 )
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Research Related to Deafness and Communication Disorders	000	4	4/25/2025	NON-COMPETING CONTINUATION	$716,811
														Subtotal = $716,811

Issue Date FY: 2024 ( Subtotal = $774,740 )
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Related to Deafness and Communication Disorders	001	3	4/25/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$743,349
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Related to Deafness and Communication Disorders	005	3	7/1/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$694,327
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Related to Deafness and Communication Disorders	002	3	5/15/2024	SUPPLEMENT FOR EXPANSION	$31,391
2024	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Research Related to Deafness and Communication Disorders	003	2	7/1/2024	NON-COMPETING CONTINUATION	-$625,507
2024	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Research Related to Deafness and Communication Disorders	004	2	7/1/2024	SUPPLEMENT FOR EXPANSION	-$68,820
2024	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Research Related to Deafness and Communication Disorders	000	2	4/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $774,740

Issue Date FY: 2023 ( Subtotal = $815,903 )
2023	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Research Related to Deafness and Communication Disorders	001	2	5/23/2023	SUPPLEMENT FOR EXPANSION	$80,870
2023	2023	UNIVERSITY OF TEXAS AT DALLAS	800 WEST CAMPBELL RD.	RICHARDSON	TX	75080	DALLAS	USA	Research Related to Deafness and Communication Disorders	000	2	4/17/2023	NON-COMPETING CONTINUATION	$735,033
														Subtotal = $815,903

Issue Date FY: 2022 ( Subtotal = $844,756 )
2022	2022	UNIVERSITY OF TEXAS AT DALLAS	800 W CAMPBELL RD	RICHARDSON	TX	75080	DALLAS	USA	Research Related to Deafness and Communication Disorders	000	1	5/19/2022	NEW	$844,756
														Subtotal = $844,756

Grand Total All Awards = $3,152,210

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Caregiver Speech and Brain-Behavior Development in Infants At-Risk for ASD

Award Number: R01DC019660

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/20/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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