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Regenerative pathways in the avian cochlea

Award Number: R01DC019619
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/10/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Regenerative pathways in the avian cochlea - Project Summary / Abstract It is known for more than 30 years that supporting cells in the normally quiescent avian hearing organ, the basilar papilla, can respond to sensory hair cell death with S-phase entry, mitotic division, and generation of replacement hair cells. The work proposed here utilizes several methodological advances for an unbiased, comprehensive, and systematic inventorying of changes in gene expression during aminoglycoside-induced hair cell death and in responding supporting cells. Pilot data obtained at multiple time points from single cells isolated from the chicken basilar papilla sensory epithelium revealed that activation of a novel pathway linked to protease-activated receptor-2, PAR2, is essential for S-phase entry of supporting cells and hair cell regeneration. The project puts forward a speci?c hypothesis for the activation pathway, which will be explicitly and thoroughly evaluated. Moreover, the identi?ed e?ector genes for the novel regeneration pathway will be assessed in a new adult mouse model for long-term hair cell loss. Here, the focus is on S-phase entry of mouse utricle and organ of Corti supporting cells four weeks after aminoglycoside-induced hair cell loss. Finally, the project will focus on the characterization of newly regenerated hair cells by reconstructing the temporal transcriptomic changes that happen when the new hair cells mature. In parallel, it is proposed to align transcriptomic data with in situ observations such as hair bundle formation, changes in planar cell polarity, reestablishment of synaptic connections, and electrophysiological features such as mechanoelectrical transduction and electrical tuning.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $545,740 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	5	1/15/2026	NON-COMPETING CONTINUATION	$491,166
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	5	2/10/2026	NON-COMPETING CONTINUATION	$54,574
														Subtotal = $545,740

Issue Date FY: 2025 ( Subtotal = $638,653 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	4	1/16/2025	NON-COMPETING CONTINUATION	$574,789
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	4	6/3/2025	NON-COMPETING CONTINUATION	$63,864
														Subtotal = $638,653

Issue Date FY: 2024 ( Subtotal = $652,884 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	3	5/2/2024	NON-COMPETING CONTINUATION	$65,287
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	3	1/12/2024	NON-COMPETING CONTINUATION	$587,597
														Subtotal = $652,884

Issue Date FY: 2023 ( Subtotal = $661,892 )
2023	2023	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	2	1/19/2023	NON-COMPETING CONTINUATION	$661,892
														Subtotal = $661,892

Issue Date FY: 2022 ( Subtotal = $661,682 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	1	2/10/2022	NEW	$661,682
														Subtotal = $661,682

Grand Total All Awards = $3,160,851

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Regenerative pathways in the avian cochlea

Award Number: R01DC019619

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/10/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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