Monday, March 2, 2026 3/2/2026

Vestibular System Function Following Blast Exposure

Award Number: R01DC019515
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Vestibular System Function Following Blast Exposure - PROJECT SUMMARY Blast exposures are unfortunately becoming a common experience in the military and public domains. Balance disorders, including dizziness, visual instability, and spatial disorientation are among the most common symptoms reported in blast injury patients. Although the etiology is unknown, it is possible that damage to the vestibular receptors and their innervating afferents has occurred, even with low blast intensity levels. We have developed a whole body blast generator (shock tube) for rodent use that delivers a pressure waveform which mimics that produced by improvised explosive devices (IED). We will capitalize on our unique expertise in vestibular research to perform a combination of anatomical, physiological, and behavioral studies to gain insight into how the vestibular system is affected by blast exposure and leads to vestibular dysfunction. In Aim 1, we will examine the anatomical structure of the semicircular canal and otolith receptors in C57/Bl6 mice, as well as their innervating afferents, in groups of animals receiving different intensities of a single blast wave exposure at multiple post-blast survival days and compare them to same age litter-mate controls with no blast exposure. In Aim 2, we will examine the dynamic response properties of canal and otolith afferents to motion stimulation following blast exposure. In Aim 3, we will examine the response vestibuloocular reflex (VOR) and its neural correlates in the vestibular nuclei in animals exposed to the same blast conditions and compare them to non-blast litter mate controls. Together, these experiments seek to understand how blast exposure affects vestibular system structure and function so that more effective protective measures and treatment options can be developed for blast exposure patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	5	1/30/2026	NON-COMPETING CONTINUATION	$0
2026	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	5	11/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $425,355 )
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	5	3/29/2025	NON-COMPETING CONTINUATION	$382,821
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	5	6/16/2025	NON-COMPETING CONTINUATION	$42,534
														Subtotal = $425,355

Issue Date FY: 2024 ( Subtotal = $425,355 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	4	2/2/2024	NON-COMPETING CONTINUATION	$382,821
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	4	5/3/2024	NON-COMPETING CONTINUATION	$42,534
														Subtotal = $425,355

Issue Date FY: 2023 ( Subtotal = $425,355 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	3	2/22/2023	NON-COMPETING CONTINUATION	$425,355
														Subtotal = $425,355

Issue Date FY: 2022 ( Subtotal = $425,355 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	2	2/11/2022	NON-COMPETING CONTINUATION	$382,821
2022	2022	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	2	4/21/2022	NON-COMPETING CONTINUATION	$42,534
														Subtotal = $425,355

Issue Date FY: 2021 ( Subtotal = $425,355 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	1	2/10/2021	NEW	$425,355
														Subtotal = $425,355

Grand Total All Awards = $2,126,775

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Vestibular System Function Following Blast Exposure

Award Number: R01DC019515

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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