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Otitis Media Diagnosis and Treatment

Award Number: R01DC019412
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/08/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Otitis Media Diagnosis and Treatment - PROJECT SUMMARY/ABSTRACT Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States (1,2), affects 90% of all children (3,4) and is the most common indication for antimicrobial therapy and surgery (5) in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity (1,3,6-30). OM continues as the most common cause of hearing loss (HL) in children and leads to speech, educational and other developmental delays (31-37). OM causes life-threatening complications (22,27) and is expensive, resulting in over $5 billion annually in U.S. health care expenditures (3,38). Despite the prevalence and difficulties with OM, diagnostic accuracy to allow appropriate treatment is lacking, leading to misplaced resources in treating OM. This proposal builds on our central hypothesis that enhanced diagnostic tools, specifically, optical coherence tomography (OCT), will yield improved diagnosis and lead to reduced need for antibiotics to treat acute OM, reduced surgical interventions for chronic otitis media, and overall fewer complications and cost associated with this disease. In this proposal we will explore three specific aims. The first aim, part A, we will perform a comparative assessment of middle ear (ME) pathology using pneumatic otoscopy (PO) and optical coherence tomography (OCT) in pediatric patients that present to a primary care clinic with complaints of otalgia (ear pain) or OM, with the hypothesis that OCT added to standard PO will improve diagnostic accuracy and reduce overall antibiotic prescriptions. In part B of this aim, a comparative assessment of ME pathology using PO along with audiology/tympanometry (TY) and OCT will be performed in pediatric patients that present to the pediatric otolaryngology clinic with a referral for chronic otitis media with effusion (OME), with the hypothesis that OCT added to standard PO and TY will improve diagnostic accuracy and reduce overall need for surgery in patients with OME. In the second aim, using the OCT images captured in the previous aim, we will develop image processing and machine learning algorithms for automated identification of effusions and biofilms in OCT image data to augment OM diagnosis for medical decision making. Finally, using the OCT images captured previously, along with our machine learning algorithms, we will establish OCT B-mode and M-mode image-based features that predict the resolution or persistence of middle ear effusions over time. Collectively, this project will demonstrate how these advances in diagnostic tools and algorithms will improve diagnosis and provide added information for clinical decision making in the management of OM.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $445,624 )
2026	2026	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Research Related to Deafness and Communication Disorders	001	5	1/30/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$445,624
2026	2025	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	000	4	1/30/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $445,624

Issue Date FY: 2025 ( Subtotal = $492,121 )
2025	2025	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	000	4	12/18/2024	NON-COMPETING CONTINUATION	$442,911
2025	2025	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	001	4	4/29/2025	NON-COMPETING CONTINUATION	$49,210
														Subtotal = $492,121

Issue Date FY: 2024 ( Subtotal = $511,632 )
2024	2024	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	000	3	1/5/2024	NON-COMPETING CONTINUATION	$460,470
2024	2024	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	001	3	5/2/2024	NON-COMPETING CONTINUATION	$51,162
														Subtotal = $511,632

Issue Date FY: 2023 ( Subtotal = $552,747 )
2023	2023	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	000	2	12/13/2022	NON-COMPETING CONTINUATION	$497,472
2023	2023	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	001	2	1/13/2023	NON-COMPETING CONTINUATION	$55,275
														Subtotal = $552,747

Issue Date FY: 2022 ( Subtotal = $576,383 )
2022	2022	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	001	1	5/9/2022	NEW	$0
2022	2022	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Research Related to Deafness and Communication Disorders	000	1	11/29/2021	NEW	$576,383
														Subtotal = $576,383

Grand Total All Awards = $2,578,507

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Otitis Media Diagnosis and Treatment

Award Number: R01DC019412

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/08/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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