Thursday, November 21, 2024 11/21/2024

Administrative Supplements to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship to Neural mechanisms of speech motor control in Autism Spectrum Disorders

Award Number: R01DC019167
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PARENT PROJECT SUMMARY Speech deficits are among the most prevalent and impairing of symptoms for people with Autism Spectrum Disorder (ASD). In fact, 25% of people with ASD have little to no speech. The reasons many people with ASD struggle to speak are still poorly understood, which means that our treatments don’t target the source of the problem. Our preliminary work has demonstrated that altering auditory feedback can influence speech in individuals with ASD. However, the ability to translate these findings to the development of novel treatments for speech deficits in ASD is impeded by our limited understanding of how auditory feedback interacts with speech motor control in individuals with ASD. In the proposed study, we will use behavioral tasks and multiple methods of advanced brain imaging to understand how brain chemicals and brain function impact a child’s ability to speak in order to identify the specific barriers to speech production for people with ASD. Specifically, we will first characterize psychophysical and neural markers of speech motor control in children and adolescents with and without ASD (Aim 1). We will then identify the mechanisms of speech motor control that are associated with clinical symptoms of speech impairment (Aim 2). Using magnetoencephalography, functional MRI and MR spectroscopy, we will then examine the relations between clinical speech abilities and brain metabolites and connectivity in the speech motor network (Aim 3). The results of the project will not only help explain why some people with ASD struggle to speak but will also open doors for development of targeted treatments to address the source of the problem for the first time, which could dramatically extend the impact of current speech therapies and even fundamentally change the prognosis for minimally verbal children with autism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	4	10/11/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,144,424 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	4	5/30/2024	NON-COMPETING CONTINUATION	$734,424
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	001	4	7/4/2024	SUPPLEMENT FOR EXPANSION	$410,000
														Subtotal = $1,144,424

Issue Date FY: 2023 ( Subtotal = $845,644 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	001	3	5/23/2023	SUPPLEMENT FOR EXPANSION	$111,220
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	3	5/22/2023	NON-COMPETING CONTINUATION	$734,424
														Subtotal = $845,644

Issue Date FY: 2022 ( Subtotal = $791,442 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	001	2	8/4/2022	SUPPLEMENT FOR EXPANSION	$111,340
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	2	5/31/2022	NON-COMPETING CONTINUATION	$680,102
														Subtotal = $791,442

Issue Date FY: 2021 ( Subtotal = $684,028 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	1	8/2/2021	NEW	$684,028
														Subtotal = $684,028

Grand Total All Awards = $3,465,538

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Administrative Supplements to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship to Neural mechanisms of speech motor control in Autism Spectrum Disorders

Award Number: R01DC019167

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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