Thursday, December 26, 2024 12/26/2024

Application of mild therapeutic hypothermia for hearing conservation during cochlear implant surgeries

Award Number: R01DC019158
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary More than half a million patients, including children, have benefitted from the remarkable technological breakthrough that are cochlear implants (CI). An increasing number of patients have some level of residual hearing at the time of implantation and can benefit from bimodal electro-acoustic devices. Surviving hair cell activity and as a result a functioning organ of Corti and neural substrate has recently been linked to speech perception outcomes. However, trauma during implantation leads to inflammation and oxidative stress that can exacerbate residual hearing loss. Successful translation of therapeutic interventions to limit pathophysiology of the injury have yet to be achieved. The present work will design and implement applications of localized, therapeutic hypothermia for protection of hair cells and neural substrate following CI. The specific aims are motivated by preliminary and published data showing that localized, mild hypothermia delivered to the cochlea is highly effective and safe, protecting hair cells and synaptic components, protecting the integrity of the cochlear blood-labyrinth barrier and preserving residual hearing long-term after implantation. Specific aim 1 will test safety and efficacy of cooling when applied to the cochlea and develop an optimal protocol for improved long-term functional and physiological outcomes. In specific aim 2 using molecular biology and immunohistochemistry techniques we will define the neuroprotective mechanisms underlying hypothermia. Combining the preclinical results with human cadaver temporal bone studies in specific aim 3, we will develop a device and system for human application. The system will enable delivery of optimized hypothermia therapy for residual structure and functional protection post-implant. Ensuring the survival of sensitive hair cells and neural structures in the cochlea are likely to lead to improved speech perception outcomes and will enable patients to benefit from future technologies and/or therapies. The results from this project can be further extended to other inner ear-related trauma such as ototoxicity, or noise- and blast-induced trauma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $364,145 )
2025	2025	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Research Related to Deafness and Communication Disorders	000	5	12/3/2024	NON-COMPETING CONTINUATION	$364,145
														Subtotal = $364,145

Issue Date FY: 2024 ( Subtotal = $404,603 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Research Related to Deafness and Communication Disorders	001	4	5/2/2024	NON-COMPETING CONTINUATION	$40,458
2024	2024	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Research Related to Deafness and Communication Disorders	000	4	12/7/2023	NON-COMPETING CONTINUATION	$364,145
														Subtotal = $404,603

Issue Date FY: 2023 ( Subtotal = $404,603 )
2023	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Research Related to Deafness and Communication Disorders	001	3	1/12/2023	NON-COMPETING CONTINUATION	$40,458
2023	2023	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Research Related to Deafness and Communication Disorders	000	3	12/9/2022	NON-COMPETING CONTINUATION	$364,145
														Subtotal = $404,603

Issue Date FY: 2022 ( Subtotal = $404,603 )
2022	2022	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Research Related to Deafness and Communication Disorders	001	2	4/20/2022	NON-COMPETING CONTINUATION	$40,459
2022	2022	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Research Related to Deafness and Communication Disorders	000	2	12/11/2021	NON-COMPETING CONTINUATION	$364,144
														Subtotal = $404,603

Issue Date FY: 2021 ( Subtotal = $419,903 )
2021	2021	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Research Related to Deafness and Communication Disorders	000	1	1/11/2021	NEW	$419,903
														Subtotal = $419,903

Grand Total All Awards = $1,997,857

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Application of mild therapeutic hypothermia for hearing conservation during cochlear implant surgeries

Award Number: R01DC019158

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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