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Mechanisms of Trace Amine-associated Receptor Gene Choice

Award Number: R01DC018738
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Mechanisms of Trace Amine-associated Receptor Gene Choice - Project Summary Odorant receptor (OR) genes exhibit an unusual form of random monoallelic expression, commonly referred to as monogenic or singular expression. In the mouse, olfactory sensory neurons express one allele of one OR gene from a large repertoire of >1,000 genes scattered throughout the genome. Current models for OR choice involve epigenetic mechanisms orchestrated by a genome-wide network of distributed enhancers. The Trace Amine Associated Receptors (TAARs) constitute a small olfactory receptor gene family that is also subject to singular expression. However, the epigenetic properties of TAARs differ from ORs in a number of key ways, calling into question whether both share a common mechanism of singular expression. The goal of this proposal is to characterize the mechanisms of singular expression of TAAR genes. We have identified the local enhancers that govern TAAR gene expression and will exploit this knowledge to test hypotheses about how these regulator elements orchestrate choice. The Aims of the proposal are to 1) identify the sequence motifs that are required for enhancer function, 2) elucidate the specificity and spatial extent of enhancer function, and 3) characterize the three-dimensional interaction landscape of the TAAR gene cluster. These experiments exploit unique aspects of the TAAR cluster to test and extend current models of monoallelic expression—a phenomenon that plays a critical role in myriad biological processes including dosage compensation, cell-type specification, phenotypic variation and disease pathogenesis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	5	2/12/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $667,633 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	6	8/7/2025	COMPETING CONTINUATION	$667,633
														Subtotal = $667,633

Issue Date FY: 2024 ( Subtotal = $484,990 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	5	8/8/2024	NON-COMPETING CONTINUATION	$484,990
														Subtotal = $484,990

Issue Date FY: 2023 ( Subtotal = $484,990 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	4	7/17/2023	NON-COMPETING CONTINUATION	$484,990
														Subtotal = $484,990

Issue Date FY: 2022 ( Subtotal = $567,734 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	3	7/11/2022	NON-COMPETING CONTINUATION	$567,734
														Subtotal = $567,734

Issue Date FY: 2021 ( Subtotal = $528,241 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	2	7/20/2021	NON-COMPETING CONTINUATION	$528,241
														Subtotal = $528,241

Issue Date FY: 2020 ( Subtotal = $512,299 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Research Related to Deafness and Communication Disorders	000	1	6/24/2020	NEW	$512,299
														Subtotal = $512,299

Grand Total All Awards = $3,245,887

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Mechanisms of Trace Amine-associated Receptor Gene Choice

Award Number: R01DC018738

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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