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The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function

Award Number: R01DC018534
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Hearing loss has a profound impact on individuals, causing communication problems, social isolation, and cognitive decline. Microvascular pathology is a significant factor seen in many types of hearing loss, including sound-induced hearing loss, age-related hearing loss, genetic hearing loss, and autoimmune inner ear disease. Normal capillary blood flow is highly controlled by pericytes. The pericytes, specialized mural cells surrounding small blood vessels adjacent to endothelial cells, are vital for normal vascular function. Pericyte pathology, such as pericyte loss or degeneration, is a significant factor in degenerative neural diseases, including Alzheimer's disease and brain dementia. The cochlear microvasculature contains an abundant population of pericytes. However, the role of pericytes in the cochlea, in general, is understudied. In particular, their roles in vascular and hearing function is largely unknown. Using a combination of well-established and cutting-edge techniques, and building on preliminary data produced under R21 support, the proposed five-year research program continues the investigation of mechanisms outlined in our current R21 grant to further explore the role of PCs, PC-related vascular pathology, and angiogenesis in cochlear health. Success in this project will open new clinical options for treatment of aging-, noise exposure-, and genetic vascular deficiency-related deafness in which PCs are compromised.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $462,579 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Related to Deafness and Communication Disorders	000	4	1/12/2023	NON-COMPETING CONTINUATION	$462,579


Issue Date FY: 2022 ( Subtotal = $389,294 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Related to Deafness and Communication Disorders	001	3	4/21/2022	NON-COMPETING CONTINUATION	$38,929
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Related to Deafness and Communication Disorders	000	3	1/21/2022	NON-COMPETING CONTINUATION	$350,365


Issue Date FY: 2021 ( Subtotal = $373,487 )
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Related to Deafness and Communication Disorders	000	2	1/11/2021	NON-COMPETING CONTINUATION	$373,487


Issue Date FY: 2020 ( Subtotal = $373,487 )
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Related to Deafness and Communication Disorders	000	1	2/28/2020	NEW	$373,487


Grand Total All Awards = $1,598,847

Sum of Action Amount is $1,598,847;

Grand Total = $1,598,847

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The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function

Award Number: R01DC018534

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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