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CRCNS: Data Sharing: Pyrfume: A library for mammalian olfactory psychophysics

Award Number: R01DC018455
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2023

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CRCNS: Data Sharing: Pyrfume: A library for mammalian olfactory psychophysics - Psychophysics refers to a class of research methods and measurements used to study a perceptual system. In olfaction research, experimental psychophysics consists of behavioral tests that illuminate the relationship between odorants and the percepts they evoke. Theoretical olfactory psychophysics attempts to makes sense of these test results by constructing models that can predict or explain them. These models then constrain broader theories of olfaction (including neural mechanisms) and inform the design of experiments that probe those mechanisms. However, many potentially illuminating datasets from academia and industry that could inform or test theoretical efforts remain difficult to locate, access, and use. Models driven by previously available data have thus been only sparsely tested and are only weakly generalizable. Pyrfume is an effort to extensively curate data related to olfactory psychophysics, to transparently and automatically determine how well models make sense of this data, and to inform experimental design for olfactory research at large. It will consist of a central , research-focused database of human psychophysics research data extracted from literature, other disparate databases, and industrial sources. It will also contain complementary research data from animal models that directly address the same kinds of questions about specific stimuli, but at a neural level inaccessible to most human experiments. All of these data will be accessible via a common framework and be immediately usable for data-driven tests of competing models of olfaction in health and disease. RELEVANCE (See instructions): Smell is essential for social behavior, food enjoyment, and danger avoidance; anosmia is associated with depression, and olfactory decline is an early warning sign for neurodegenerative diseases. This project organizes understanding of human olfaction, facilitating quantification of olfactory health, disease biomarker development, and cures for olfactory disorders. Optometry and audiology are refined clinical tools that map perceptual deficits onto medical targets; this work can help advance olfactometry to the same level.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$28,322 )
2024	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Research Related to Deafness and Communication Disorders	000	3	2/23/2024	NON-COMPETING CONTINUATION	-$28,322
														Subtotal = -$28,322

Issue Date FY: 2021 ( Subtotal = $141,104 )
2021	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Research Related to Deafness and Communication Disorders	000	3	7/1/2021	NON-COMPETING CONTINUATION	$141,104
														Subtotal = $141,104

Issue Date FY: 2020 ( Subtotal = $147,946 )
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Research Related to Deafness and Communication Disorders	000	2	7/29/2020	NON-COMPETING CONTINUATION	$147,946
														Subtotal = $147,946

Issue Date FY: 2019 ( Subtotal = $146,376 )
2019	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Research Related to Deafness and Communication Disorders	000	1	7/12/2019	NEW	$146,376
														Subtotal = $146,376

Grand Total All Awards = $407,105

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CRCNS: Data Sharing: Pyrfume: A library for mammalian olfactory psychophysics

Award Number: R01DC018455

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2023

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