Saturday, October 5, 2024 10/5/2024

Advanced Detection and Differential Diagnosis of Hearing Loss Using Otoacoustic Emissions

Award Number: R01DC018307
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Most sensory hearing loss is diagnosed and treated with little distinction. Indeed, ”sensorineural hearing loss” is a catch-all term. However, promising results over the last few years suggest that otoacoustic emissions (OAEs) can distinguish among sensory hearing losses that appear similar by audiogram. OAEs are non- invasive indicators of cochlear health and dysfunction that can be recorded in normal hearers and those with up to moderate degrees of hearing impairment. Though they offer a non-invasive, pre-neural window into the cochlea, their application in the audiology clinic has stagnated over the last two decades despite significant advances in the laboratory. Current clinical utility of OAEs includes only the detection of hearing loss; nothing is learned about the etiology of the hearing loss once detected. This project proposes to translate into the audiology clinic a rapid, research-proven technique to evoke OAEs with sweeping tones, allowing for the efficient, near-simultaneous recording of the two basic OAE classes: emissions produced by cochlear nonlinearities such as the distortion-product OAE (DPOAE), and those produced by cochlear reflections such as the stimulus-frequency OAE (SFOAE). These two types of emissions elucidate distinct cochlear properties, and each is uniquely sensitive to different auditory pathologies and etiologies. Analyzing combined OAE outcomes produces new relational metrics that exploit the unique diagnostic information offered by both, which initiates differential diagnosis of sensory hearing loss. Additionally, our advanced OAE system has incorporated innovative calibration techniques that mitigate the effects of ear-canal standing-wave interference, a known source of undesirable variability. These advanced calibrations improve the test-retest reliability of emissions, which allows for more accurate serial monitoring of hearing status and an expanded high-frequency test range. In this project, we will: 1) integrate existing software modules that calibrate, measure, and analyze swept-tone OAEs into a cohesive and user-friendly software program for the interleaved recording of DPOAEs and SFOAEs; 2) analyze DPOAE and SFOAE measures in a combined fashion to detect and monitor hearing loss and perform differential diagnosis for hearing impairments of confirmed etiology; and 3) strategically pare down the Combined-OAE Profile and validate its performance in an independent group of participants to produce an abbreviated clinical test for the diagnosis of sensory hearing loss. These steps will modernize and advance OAE assessment well beyond the rudimentary goal of detecting hearing loss and provide a degree of diagnostic specificity that will facilitate personalized intervention for individuals with hearing loss.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	5	8/27/2024	NON-COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2023 ( Subtotal = $588,048 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	4	8/17/2023	NON-COMPETING CONTINUATION	$588,048
2023	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	3	1/24/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $588,048

Issue Date FY: 2022 ( Subtotal = $636,303 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	3	8/17/2022	NON-COMPETING CONTINUATION	$636,303
2022	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	2	4/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $636,303

Issue Date FY: 2021 ( Subtotal = $614,800 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	2	8/11/2021	NON-COMPETING CONTINUATION	$614,800
														Subtotal = $614,800

Issue Date FY: 2020 ( Subtotal = $464,074 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	1	6/15/2020	NEW	$464,074
														Subtotal = $464,074

Grand Total All Awards = $2,303,226

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Advanced Detection and Differential Diagnosis of Hearing Loss Using Otoacoustic Emissions

Award Number: R01DC018307

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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