Monday, May 16, 2022 5/16/2022

Neural oscillations underlying speech perception and production in childhood stuttering

Award Number: R01DC018283
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract There is a fundamental gap in our understanding of the temporal dynamics underlying the auditory-motor integration deficits consistently observed in children and adults who stutter. Fluent speech requires coordinated neuronal activity that is achieved through neural oscillatory synchrony across brain structures. This proposal will focus on the oscillatory synchrony facilitating neural communication within the speech network. Our long-term goal is to determine empirically-based neural markers for persistent stuttering, findings that may eventually inform the clinical diagnosis and treatment of childhood stuttering. The overall objective of the present application is to determine how children who stutter (CWS) differ from fluent peers in neural oscillatory synchrony across auditory-motor structures during speech perception and planning. Guided by EEG and MRI data collected from children who do and do not stutter, our central hypothesis is that beta oscillations, which control predictive timing of movements through coordination of motor to auditory systems, will show aberrant power, reduced inter- trial phase clustering, and reduced interregional oscillatory phase synchrony in CWS. A better understanding in this area has exciting treatment implications, since manipulation of synchrony within oscillatory patterns in auditory-motor systems may be possible through entrainment with external sensory stimuli and non-invasive brain stimulation. This project will thus allow us to lay the groundwork towards systematic, neurobiology-based intervention development for CWS. Guided by strong preliminary data, the central hypotheses will be tested by pursuing three specific aims: 1. Identify and characterize beta power and oscillatory synchrony in auditory- motor cortical areas during speech perception and planning in CWS. 2. Compare beta power and oscillatory synchrony in auditory-motor cortical areas during natural and entrained (paced) speech planning in CWS. 3. Determine how beta oscillation characteristics in auditory-motor areas relate to structural and functional connectivity among auditory, motor and striatal regions in CWS. The proposed work is innovative, as it will be the first series of studies designed to characterize neural oscillatory synchrony specific to speech processing in CWS, which may serve as a highly predictive neural marker for persistent stuttering during early childhood. Findings will be significant, because the expected results will elucidate, for the first time, causal mechanisms behind auditory-motor integration deficits in persistent stuttering. Such results will have an important positive impact, as the identified neural mechanisms underlying fluent speech will lay the foundation for effective early intervention for stuttering.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $511,462 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	3	12/28/2021	NON-COMPETING CONTINUATION	$460,317
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	001	3	4/22/2022	NON-COMPETING CONTINUATION	$51,145


Issue Date FY: 2021 ( Subtotal = $413,229 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	001	2	1/8/2021	NON-COMPETING CONTINUATION	$41,322
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	2	12/28/2020	NON-COMPETING CONTINUATION	$371,907


Issue Date FY: 2020 ( Subtotal = $440,418 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Research Related to Deafness and Communication Disorders	000	1	12/20/2019	NEW	$440,418


Grand Total All Awards = $1,365,109

Sum of Action Amount is $1,365,109;

Grand Total = $1,365,109

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Neural oscillations underlying speech perception and production in childhood stuttering

Award Number: R01DC018283

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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