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Mechanisms of inflammation-triggered taste loss and its recovery

Award Number: R01DC018042
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2027
AWARD TERMINATION DATE: 06/09/2025

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Mechanisms of inflammation-triggered taste loss and its recovery - PROJECT SUMMARY Taste loss can lead to malnutrition, weight loss, and depression. In addition, changes in taste are a symptom of poor health. This cyclical relationship between taste and health highlights the importance of research aimed at understanding taste loss in both health and disease. Research on taste loss will provide new approaches in the prevention, diagnosis, and treatment of disease. It is well-documented that infections and autoimmune conditions are accompanied by changes in chemosensory perception including changes in taste. However, currently we know little about how taste bud regeneration is regulated, and there is no effective treatment for taste loss. Our recent research indicates that inflammation, characterized by induction of inflammatory cytokines and infiltration and activation of immune cells, contributes significantly to taste dysfunction. We hypothesize that inflammation, particularly through the action of the inflammatory cytokine interferon-γ (IFN-γ), contributes to taste loss by inducing cell death and inhibiting taste bud cell renewal, and that resolution of inflammation promotes taste bud regeneration. IFN-γ can be produced by various types of immune and nonimmune cells in response to infections and autoimmunity. Its levels in taste tissues are markedly increased in an autoimmune disease model with taste loss. Yet, whether IFN-γ directly contributes to taste loss has not been determined. In this project, we propose to investigate the role of inflammation, especially IFN-γ, in taste loss using both a transgenic approach and a clinically relevant respiratory viral infection model. We will then use these taste loss models to study the mechanisms of taste bud regeneration. This research will test mechanistic hypotheses of how inflammation and infection cause taste loss, and how taste responses recover. To underscore the importance of research investigating the link between inflammation, disease, and taste loss, a considerable number of COVID-19 patients experience taste dysfunction. Although most cases of taste loss are temporary, including taste loss associated with SARS-CoV-2 infection, long-term taste loss can occur in some patients. Thus, insights from this research will be informative to better understand taste loss in general, as well as taste loss associated with COVID-19.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	5	3/9/2026	NON-COMPETING CONTINUATION	$0
2026	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	2	2/17/2026	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $424,263 )
2025	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	004	4	6/9/2025	TERMINATION	$0
2025	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	5	4/10/2025	NON-COMPETING CONTINUATION	$320,111
2025	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	003	5	4/21/2025	NON-COMPETING CONTINUATION	$35,567
2025	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	4	12/4/2024	SUPPLEMENT FOR EXPANSION	$68,585
2025	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	2	12/13/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $424,263

Issue Date FY: 2024 ( Subtotal = $343,655 )
2024	2024	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	4	3/27/2024	NON-COMPETING CONTINUATION	$343,655
2024	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	2	11/21/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $343,655

Issue Date FY: 2023 ( Subtotal = $348,801 )
2023	2023	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	3	3/17/2023	NON-COMPETING CONTINUATION	$348,801
														Subtotal = $348,801

Issue Date FY: 2022 ( Subtotal = $780,118 )
2022	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	2	7/29/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	2	4/1/2022	NON-COMPETING CONTINUATION	$356,810
2022	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	2	7/26/2022	SUPPLEMENT FOR EXPANSION	$423,308
														Subtotal = $780,118

Issue Date FY: 2021 ( Subtotal = $352,641 )
2021	2021	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	1	2/25/2021	NEW	$352,641
														Subtotal = $352,641

Grand Total All Awards = $2,249,478

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Mechanisms of inflammation-triggered taste loss and its recovery

Award Number: R01DC018042

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2027

AWARD TERMINATION DATE: 06/09/2025

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