Thursday, July 31, 2025 7/31/2025

Diversity Supplement to R01 DC018042

Award Number: R01DC018042
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Diversity Supplement to R01 DC018042 - PROJECT SUMMARY Chemosensory dysfunction negatively affects human health; severe chemosensory loss leads to malnutrition, weight loss, and depression. Taste disorders can develop with various diseases, including many with underlying inflammation. The prevalence of taste dysfunction in individuals with inflammation caused by infections and autoimmune diseases is well-documented, but the mechanisms supporting these phenomena are not. To underscore the importance of research investigating the link between inflammation, disease, and taste loss, a considerable number of COVID-19 patients experience taste dysfunction. Although most cases of taste loss are temporary, including taste loss associated with SARS-CoV-2 infection, long-term taste loss can occur in some patients. Currently we know little about the mechanisms of long-term chemosensory loss and there is no effective treatment for chemosensory loss. This project will investigate the role of inflammation, particularly through the action of the inflammatory cytokine interferon-γ (IFN-γ), in taste loss using both a transgenic approach and a clinically relevant respiratory viral infection model. We will then use these taste loss models to study the mechanisms of taste bud regeneration. This diversity supplement seeks funds to enable Mr. Elias Mimouni, a Black U.S. citizen with chemistry and data science background, to learn research techniques in the chemosensory field and gain research experience investigating chemosensory disorders. Mr. Mimouni is currently finishing a Master’s degree in Chemistry at the University of Pennsylvania while gaining research experience as a Visiting Student supported by a private funding in the Wang lab at the Monell Chemical Senses Center. His career goal is to go to medical school and ultimately become a physician scientist. We are seeking funding to support Mr. Mimouni as a post-baccalaureate trainee so that he can receive advanced training and contribute at a higher level to an NIH-funded chemosensory research project. To this end, we have carefully constructed a training plan that will facilitate Mr. Mimouni’s technical, intellectual, and career development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $424,263 )
2025	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	004	4	6/9/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	5	4/10/2025	NON-COMPETING CONTINUATION	$320,111
2025	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	003	5	4/21/2025	NON-COMPETING CONTINUATION	$35,567
2025	2025	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	4	12/4/2024	SUPPLEMENT FOR EXPANSION	$68,585
2025	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	2	12/13/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $424,263

Issue Date FY: 2024 ( Subtotal = $343,655 )
2024	2024	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	4	3/27/2024	NON-COMPETING CONTINUATION	$343,655
2024	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	2	11/21/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $343,655

Issue Date FY: 2023 ( Subtotal = $348,801 )
2023	2023	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	3	3/17/2023	NON-COMPETING CONTINUATION	$348,801
														Subtotal = $348,801

Issue Date FY: 2022 ( Subtotal = $780,118 )
2022	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	2	7/29/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	2	4/1/2022	NON-COMPETING CONTINUATION	$356,810
2022	2022	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	2	7/26/2022	SUPPLEMENT FOR EXPANSION	$423,308
														Subtotal = $780,118

Issue Date FY: 2021 ( Subtotal = $352,641 )
2021	2021	MONELL CHEMICAL SENSES CENTER	3500 MARKET ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	1	2/25/2021	NEW	$352,641
														Subtotal = $352,641

Grand Total All Awards = $2,249,478

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Diversity Supplement to R01 DC018042

Award Number: R01DC018042

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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