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Neural circuits for regulating social behavior in rodents

Award Number: R01DC017234
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Neural circuits for regulating social behavior in rodents - Project Summary Innate social behaviors such as aggression, mating, and parenting offer a powerful window on the brain networks that map sensory input onto appropriate motor outputs. The compact architecture of the rodent vomeronasal system is ideal for characterizing the circuits that translate identified, sex-specific chemosignals into responses matched to the characteristics of different conspecifics. Here we address two seemingly contradictory roles of this system: the need to mediate stereotyped interactions with same- or opposite-sex partners, while still providing flexibility in responses to different individuals based on established social relationships. We characterize the learning mechanisms that mediate changes in aggression, a prototypical and highly robust male behavior that is powerfully altered by dominance relationships. Using powerful genetic tools to access functionally distinct sensory pathways in the accessory olfactory bulb, our experiments will address (1) the cellular plasticity processes that adapt aggression levels to reflect social experience, (2) the way that familiarity shapes the sensory representations of conspecifics during active social interactions, and (3) the circuit anatomy that organizes behaviorally relevant sensory signals and routes them to downstream limbic centers. A deeper understanding of the neural mechanisms for regulating aggression may help design strategies for mitigating pathological behaviors in human communities. More broadly, a deeper knowledge of the brain networks for social behaviors is highly relevant for understanding autism spectrum disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	6/12/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $324,837 )
2023	2023	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	2/7/2023	NON-COMPETING CONTINUATION	$324,837
														Subtotal = $324,837

Issue Date FY: 2022 ( Subtotal = $333,252 )
2022	2022	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	4	4/21/2022	NON-COMPETING CONTINUATION	$33,325
2022	2022	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	4	2/14/2022	NON-COMPETING CONTINUATION	$299,927
														Subtotal = $333,252

Issue Date FY: 2021 ( Subtotal = $340,966 )
2021	2021	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	3	2/12/2021	NON-COMPETING CONTINUATION	$340,966
														Subtotal = $340,966

Issue Date FY: 2020 ( Subtotal = $256,997 )
2020	2020	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	2	1/24/2020	NON-COMPETING CONTINUATION	$256,997
														Subtotal = $256,997

Issue Date FY: 2019 ( Subtotal = $256,997 )
2019	2019	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	1	2/22/2019	NEW	$256,997
														Subtotal = $256,997

Grand Total All Awards = $1,513,049

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Neural circuits for regulating social behavior in rodents

Award Number: R01DC017234

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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