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Functional reorganization of the language and domain-general multiple demand systems in aphasia

Award Number: R01DC016950
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2019
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Functional reorganization of the language and domain-general multiple demand systems in aphasia - PROJECT ABSTRACT Aphasia affects approximately one third of stroke survivors (Berthier, 2005), and between 30 and 43% of these remain severely affected in the long term (e.g. (Bakheit et al., 2007). With a rising burden of stroke, it is increasingly important to develop effective and individualized treatment for patients with aphasia. An understanding of the brain mechanisms that underlie plasticity and recovery is therefore essential. However, the problem to solve is far from trivial given that language impairment and recovery after stroke is impacted by many factors including premorbid differences in brain organization, size and site of lesion, and post-stroke behaviors. In the proposed work, we examine the brain regions that are capable of subserving language recovery. While the prevailing hypothesis is that language recovery is mediated by the regions of the fronto-temporal network – either the ipsilesional left-hemisphere (LH) regions or the homologous right-hemisphere (RH) regions, we examine a novel hypothesis that a domain-general fronto-parietal multiple demand (MD) network may also mediate language recovery in patients with aphasia (PWA). We propose to evaluate three possible changes in the functional architecture of the MD and language networks: (i) response magnitude in each network during language processing; (ii) intra-network synchronization among MD regions, and among language regions; and (iii) across-network synchronization between MD and language regions. We will first characterize post-stroke differences in each measure by comparing 40 chronic PWA and 40 age-matched controls. Then, we will identify individual differences in neural signatures that co-vary with differences in language performance on standard behavioral tests. Finally, we will assess the causal contribution of the MD network to language recovery in a subset of 40 PWA tested at two time points, both in fMRI and behavioral tasks. This work is innovative because it uses a suite of methodological tools to facilitate localize language processing in PWA by accounting for variability in lesion site, volume and anatomy-function mapping. Further, we examine a subset of patients at two time points, allowing a within group comparison of changes in the MD network over time and as a function of recovery. A key outcome of this project is the development of a comprehensive explanation for mechanisms of neuroplasticity and reorganization of language function in aphasia. Another outcome of the project is the delineation of neural phenotypes – including in the acute stage – that explain the variability in linguistic and cognitive performance of PWA while accounting for variability in anatomy-function mapping. A third important outcome will be to pave the way for new behavioral and neuro-stimulation therapies that capitalize on the engagement of the MD network in the service of language recovery. Establishing the potential recruitment of non-language regions (i.e., multiple demand regions) in the service of language recovery has profound implications for facilitating language recovery in aphasia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	2/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $624,183 )
2023	2023	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	3/23/2023	NON-COMPETING CONTINUATION	$624,183
														Subtotal = $624,183

Issue Date FY: 2022 ( Subtotal = $624,183 )
2022	2022	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	4	4/6/2022	NON-COMPETING CONTINUATION	$624,183
														Subtotal = $624,183

Issue Date FY: 2021 ( Subtotal = $624,183 )
2021	2021	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	3	3/18/2021	NON-COMPETING CONTINUATION	$624,183
														Subtotal = $624,183

Issue Date FY: 2020 ( Subtotal = $624,183 )
2020	2020	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	2	3/29/2020	NON-COMPETING CONTINUATION	$624,183
														Subtotal = $624,183

Issue Date FY: 2019 ( Subtotal = $660,848 )
2019	2019	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	1	3/6/2019	NEW	$660,848
2019	2019	TRUSTEES OF BOSTON UNIVERSITY	1 SILBER WAY	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	1	3/28/2019	NEW	$0
														Subtotal = $660,848

Grand Total All Awards = $3,157,580

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Functional reorganization of the language and domain-general multiple demand systems in aphasia

Award Number: R01DC016950

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2019

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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