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neurophysiology behavioral role and organization of the auditory parabelt

Award Number: R01DC015780
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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neurophysiology behavioral role and organization of the auditory parabelt - Project summary/abstract Primate auditory cortex is composed of areas grouped in regions at 3 levels in a hierarchical order: core-belt- parabelt. Each region is subdivided into multiple areas. Auditory information processing proceeds through levels and through areas within every level. Information in the belt and parabelt regions diverges into parietal (dorsal) and temporal lobe (ventral), as well as different regions of prefrontal cortex. Growing evidence indicates that the representation of auditory information becomes more complex and abstract as the processing advances. This project focuses on the properties of the parabelt (PB) region on the superior temporal gyrus (STG) in macaque monkeys for two reasons. First, while PB is fairly well defined at a gross anatomical level in monkeys (e.g. it divides into caudal and rostral areas, CPB and RPB, respectively) detailed anatomical studies (architecture, intrinsic connectivity between CPB and RPB) have not been conducted. More detailed microstructural characterization of the macaque PB may help to better define the human PB. Second, while human STG has been implicated in various functions particularly related to perception of communication signals like speech, the physiological properties of the macaque PB have not been systematically studied, primarily due to the technical difficulties of accessing the macaque STG. Thus, the detailed auditory physiology of the macaque PB holds some of the key information missing in our understanding of the organization and functioning of the primate auditory cortex. Our BROAD OBJECTIVE is to characterize the physiological properties, functions and organization of the PB areas in primates. As PB areas are widely regarded as task-sensitive, we will record PB activity in monkeys performing sensory tasks that entail active discrimination of the test stimuli. SPECIFIC AIM 1 is to systematically characterize acoustic preferences (e.g. spectral and temporal tuning) of the PB neurons by examine their responsiveness to a battery of auditory stimuli. This will provide the first ever detailed survey of basic PB physiology. SPECIFIC AIM 2 is to characterize communication signal processing in PB. We examine neural responses to conspecific vocalization while manipulating their sensory modality or spectral/temporal domains and relate these responses to behavioral performance. Both AIMs also allow comparisons between CPB and RPB, and between hemispheres, to provide more details about PB organization. SPECIFIC AIM 3 is to investigate the network architecture of PB by exploring the connection patterns of PB anatomically and neurophysiologically. This will help understand how PB areas interact to process information and pass it to higher order areas. Several communication disorders (e.g. autism) implicate STG or higher level of auditory systems for its impaired functionality. Basic properties of STG (PB areas in the case of monkeys) are essential for understanding these, as well as basic sensory impairments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD BLDG 35	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	5	12/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $23,458 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	001	5	4/19/2023	SUPPLEMENT FOR EXPANSION	$23,458
2023	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	5	11/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $23,458

Issue Date FY: 2021 ( Subtotal = $340,245 )
2021	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	5	11/7/2020	NON-COMPETING CONTINUATION	$306,220
2021	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	001	5	1/8/2021	NON-COMPETING CONTINUATION	$34,025
														Subtotal = $340,245

Issue Date FY: 2020 ( Subtotal = $340,252 )
2020	2020	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	001	4	1/16/2020	NON-COMPETING CONTINUATION	$34,026
2020	2020	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	4	11/18/2019	NON-COMPETING CONTINUATION	$306,226
														Subtotal = $340,252

Issue Date FY: 2019 ( Subtotal = $340,258 )
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	3	11/15/2018	NON-COMPETING CONTINUATION	$340,258
														Subtotal = $340,258

Issue Date FY: 2018 ( Subtotal = $345,510 )
2018	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	001	2	4/4/2018	NON-COMPETING CONTINUATION	$34,552
2018	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	2	11/22/2017	NON-COMPETING CONTINUATION	$310,958
														Subtotal = $345,510

Issue Date FY: 2017 ( Subtotal = $321,001 )
2017	2017	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Related to Deafness and Communication Disorders	000	1	11/7/2016	NEW	$321,001
														Subtotal = $321,001

Grand Total All Awards = $1,710,724

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neurophysiology behavioral role and organization of the auditory parabelt

Award Number: R01DC015780

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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