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Differential Diagnosis of Functional Speech Deficits in Children with Cerebral Palsy

Award Number: R01DC015653
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Differential Diagnosis of Functional Speech Deficits in Children with Cerebral Palsy - Project Summary Approximately 50% of children with cerebral palsy (CP) have the speech disorder dysarthria. Dysarthria is difficult to identify in young children because its characteristics (speech subsystem features) overlap with features of early typical development. Quantitative standards for differentiating typical from atypical speech subsystem development in children do not currently exist. This research seeks to improve early identification and treatment of dysarthria in children with CP by creating clinically accessible, data-based developmental standards that allow us to differentiate between typical and atypical auditory-perceptual speech subsystem features in children. To do this, we will validate an English adaptation of the pediatric version of the well- established Bogenhausen Dysarthria Scales (BoDyS-Kid), including 31 subsystem-based perceptual speech features and 10 domains. The research will capitalize on speech samples from 573 typically developing (TD) children, collected in the first funding cycle; and 74 children with cerebral palsy (699 longitudinal speech samples). We will collect new data from 1300 speech language pathologists (SLPs) who will make auditory- perceptual ratings of children’s speech using the BoDyS-Kid, comprising the first ever large-scale comprehensive study of the development of speech subsystem based auditory-perceptual features in English- speaking children. Specific aims are: 1.) To quantify the maturation of auditory-perceptual speech subsystem features and domains in typically developing children. 2.) To quantify the maturation of auditory-perceptual speech subsystem features and domains in children with cerebral palsy. 3.) To identify and quantify auditory- perceptual speech subsystem features and domains that discriminate among clinical groups and are associated with speech intelligibility for children with CP and TD. Products of this research will be a.) a theoretically grounded and validated clinical tool for auditory-perceptual assessment of speech subsystem features/domains in English speaking children for use by practicing clinical SLPs to support differential diagnosis of speech disorders; b.) a set of normative standards that quantify the course of acquisition and define an expected range of variability by age for auditory-perceptual speech subsystem features/domains; c.) quantitative characterization of longitudinal patterns of subsystem feature/domain acquisition in children with CP (with and without dysarthria), and d.) foundational knowledge of specific features/domains that best differentiate between typical and dysarthric speech development, and a quantitative understanding of the relative contributions of subsystem features/domains and clusters thereof to children’s speech intelligibility. Results will advance the development and validation of evidence-based clinical speech assessment methods for pediatric dysarthria that will provide a clinically accessible explanatory basis for intelligibility deficits across speech subsystems that can be used to direct treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $631,114 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	003	7	7/10/2024	NON-COMPETING CONTINUATION	$631,114
2024	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	002	6	6/25/2024	COMPETING CONTINUATION	$456
2024	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	6	10/13/2023	COMPETING CONTINUATION	$0
2024	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	001	5	6/25/2024	NON-COMPETING CONTINUATION	-$456
														Subtotal = $631,114

Issue Date FY: 2023 ( Subtotal = $663,910 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	6	9/18/2023	COMPETING CONTINUATION	$663,910
														Subtotal = $663,910

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	5	5/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $473,130 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	5	6/23/2020	NON-COMPETING CONTINUATION	$473,130
														Subtotal = $473,130

Issue Date FY: 2019 ( Subtotal = $463,071 )
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	001	4	6/27/2019	NON-COMPETING CONTINUATION	$463,071
2019	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	3	6/25/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $463,071

Issue Date FY: 2018 ( Subtotal = $485,139 )
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	3	6/20/2018	NON-COMPETING CONTINUATION	$485,139
														Subtotal = $485,139

Issue Date FY: 2017 ( Subtotal = $477,031 )
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	2	6/30/2017	NON-COMPETING CONTINUATION	$477,031
														Subtotal = $477,031

Issue Date FY: 2016 ( Subtotal = $411,154 )
2016	2016	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	1	7/7/2016	NEW	$411,154
														Subtotal = $411,154

Grand Total All Awards = $3,604,549

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Differential Diagnosis of Functional Speech Deficits in Children with Cerebral Palsy

Award Number: R01DC015653

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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