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Cochlear mechanics in the mouse

Award Number: R01DC014450
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2015
PERIOD OF PERFORMANCE END DATE: 02/28/2031

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Cochlear mechanics in the mouse - Project Summary/Abstract Sound pressure produces force across the mammalian cochlear partition, creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non- mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells (OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how and why the complex biomechanics of the 3D multi-cellular and acellular arrangement that form the organ of Corti work together to create cochlear amplification, ultimately shaping the signals within the inner hair cells (IHCs) and auditory nerve. Specifically, we will determine how this process, which stems from the broadly-tuned basilar membrane, creates sharper frequency tuning. This question is significant on a basic science level because these biophysical processes underlie the ability to hear sounds just above the Brownian motion of molecules in air with an exquisite frequency resolution. This question remains unsolved and is clinically important because hearing loss, typically due to loss of cochlear amplification, reduces the understanding of speech in noisy environments. Our central hypothesis is that the afferent auditory nerve signal is not fully described by basilar membrane vibration. In aim 1, We will measure the vibration from 15-20 sequential IHC stereociliary bundles and from the center of the basilar membrane at the same longitudinal locations using OCM in vivo. We will assess whether IHC bundle vibration matches basilar membrane vibration. In aim 2, We will measure calcium levels in type I afferent auditory nerves under the IHCs in vivo during the presentation of sound stimuli using two-photon fluorescence imaging. We will correlate the spatial distribution of changes in calcium with the vibratory responses of IHC bundles collected within the same mouse. Together, these data will be interpreted to test our hypothesis. If our hypothesis is true, IHC bundles will vibrate differently than the basilar membrane and this difference will vary with the relative proportion of cochlear amplification. Furthermore, we expect auditory nerve activity to correlate with IHC stereociliary bundle stimulation and not necessarily basilar membrane vibration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $705,268 )
2026	2026	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	12	2/3/2026	COMPETING CONTINUATION	$705,268
2026	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	11	2/3/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $705,268

Issue Date FY: 2024 ( Subtotal = $623,326 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	11	4/9/2024	NON-COMPETING CONTINUATION	$623,326
														Subtotal = $623,326

Issue Date FY: 2023 ( Subtotal = $623,326 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	10	4/12/2023	NON-COMPETING CONTINUATION	$623,326
														Subtotal = $623,326

Issue Date FY: 2022 ( Subtotal = $623,326 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	9	4/26/2022	NON-COMPETING CONTINUATION	$623,326
														Subtotal = $623,326

Issue Date FY: 2021 ( Subtotal = $625,265 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	8	4/16/2021	NON-COMPETING CONTINUATION	$625,265
2021	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	002	7	6/7/2021	COMPETING CONTINUATION	$46,390
2021	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	6	6/7/2021	NON-COMPETING CONTINUATION	-$46,390
														Subtotal = $625,265

Issue Date FY: 2020 ( Subtotal = $637,608 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	7	4/16/2020	COMPETING CONTINUATION	$637,608
														Subtotal = $637,608

Issue Date FY: 2019 ( Subtotal = $348,844 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	6	4/5/2019	NON-COMPETING CONTINUATION	$348,844
														Subtotal = $348,844

Issue Date FY: 2018 ( Subtotal = $348,977 )
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	002	5	4/26/2018	NON-COMPETING CONTINUATION	$348,977
2018	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	4	11/3/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$199,077
2018	2016	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	2	11/3/2017	NON-COMPETING CONTINUATION	-$199,077
														Subtotal = $348,977

Issue Date FY: 2017 ( Subtotal = $350,399 )
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	003	4	8/31/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$350,399
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	3	5/24/2017	NON-COMPETING CONTINUATION	$34,222
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	3	5/2/2017	NON-COMPETING CONTINUATION	$307,982
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	002	3	8/31/2017	NON-COMPETING CONTINUATION	-$342,204
														Subtotal = $350,399

Issue Date FY: 2016 ( Subtotal = $346,988 )
2016	2016	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	2	4/6/2016	NON-COMPETING CONTINUATION	$346,988
														Subtotal = $346,988

Issue Date FY: 2015 ( Subtotal = $346,834 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	1	4/22/2015	NEW	$346,834
														Subtotal = $346,834

Grand Total All Awards = $5,580,161

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Cochlear mechanics in the mouse

Award Number: R01DC014450

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2015

PERIOD OF PERFORMANCE END DATE: 02/28/2031

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