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Cholinergic modulation of olfactory coding.

Award Number: R01DC013779
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2015
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Cholinergic modulation of olfactory coding. - Project Summary Understanding how brain states influence sensory coding is fundamental in advancing our knowledge of the mechanisms by which neural circuits encode sensory information. The basal forebrain cholinergic system has long been implicated in such state changes and has been shown to play a crucial role in the detection, selection, and processing of behaviorally relevant stimuli. However, to date, almost all work regarding cholinergic modulation of olfactory circuits has focused on the effects of acetylcholine on olfactory system neurons while largely ignoring the circumstances that drive cholinergic neuron activity. Thus, very little is currently known regarding the conditions that drive basal forebrain cholinergic neuron activity or the characteristics of cholinergic fiber activity within the olfactory bulb. Further, fundamental questions also remain regarding the primary function of ACh release on olfactory coding, as most prior studies have focused on olfactory responses in anesthetized mice. For example, in the olfactory bulb, acetylcholine release is thought to enhance the sensitivity of olfactory bulb output cell odor responses and lead to improved olfactory discrimination. However, no experiments have been performed directly addressing these hypothesized functions in awake animals, leaving acetylcholine’s ultimate function within early olfactory regions unknown. The overall goal of this project is to understand this process by investigating how sensory input, stimulus novelty, and odor discrimination drive olfactory projecting cholinergic neuron activity and how this impacts olfactory odor responses. Our central hypothesis is that olfactory projecting cholinergic neurons preferentially respond to novel stimuli and impart information regarding salience to the olfactory circuits. We will use calcium imaging of defined cholinergic and olfactory system cell types combined with chemogenetic manipulation in awake animals during well-characterized olfactory-mediated behaviors to test this hypothesis. The findings of these experiments will be significant in that they will fundamentally advance our knowledge of the function of cholinergic input during olfactory-related events, how this affects sensory representations at multiple levels within the olfactory system, and how this ultimately impacts olfactory perception and discrimination.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $460,908 )
2025	2025	UNIVERSITY OF TENNESSEE	62 S DUNLAP ST	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	9	5/19/2025	NON-COMPETING CONTINUATION	$460,908
														Subtotal = $460,908

Issue Date FY: 2024 ( Subtotal = $460,908 )
2024	2024	UNIVERSITY OF TENNESSEE	62 S DUNLAP ST	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	8	5/8/2024	NON-COMPETING CONTINUATION	$460,908
														Subtotal = $460,908

Issue Date FY: 2023 ( Subtotal = $460,908 )
2023	2023	UNIVERSITY OF TENNESSEE	62 S DUNLAP ST	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	7	5/23/2023	NON-COMPETING CONTINUATION	$460,908
														Subtotal = $460,908

Issue Date FY: 2022 ( Subtotal = $465,422 )
2022	2022	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	6	6/9/2022	COMPETING CONTINUATION	$465,422
2022	2022	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	004	6	8/29/2022	COMPETING CONTINUATION	$17
2022	2022	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	002	6	7/13/2022	COMPETING CONTINUATION	$24,564
2022	2019	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	003	5	8/29/2022	NON-COMPETING CONTINUATION	-$17
2022	2019	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	001	5	7/13/2022	NON-COMPETING CONTINUATION	-$24,564
														Subtotal = $465,422

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	5	1/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $345,473 )
2019	2019	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	5	2/4/2019	NON-COMPETING CONTINUATION	$345,473
														Subtotal = $345,473

Issue Date FY: 2018 ( Subtotal = $354,494 )
2018	2018	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	001	4	4/4/2018	NON-COMPETING CONTINUATION	$35,450
2018	2018	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	4	2/12/2018	NON-COMPETING CONTINUATION	$319,044
														Subtotal = $354,494

Issue Date FY: 2017 ( Subtotal = $363,245 )
2017	2017	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	3	2/9/2017	NON-COMPETING CONTINUATION	$326,920
2017	2017	UNIVERSITY OF TENNESSEE	62 S DUNLAP STREET STE 103	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	001	3	5/24/2017	NON-COMPETING CONTINUATION	$36,325
														Subtotal = $363,245

Issue Date FY: 2016 ( Subtotal = $371,749 )
2016	2016	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	2	2/24/2016	NON-COMPETING CONTINUATION	$371,749
														Subtotal = $371,749

Issue Date FY: 2015 ( Subtotal = $368,196 )
2015	2015	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	001	1	3/4/2015	NEW	$3,409
2015	2015	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Research Related to Deafness and Communication Disorders	000	1	2/11/2015	NEW	$364,787
														Subtotal = $368,196

Grand Total All Awards = $3,651,303

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Cholinergic modulation of olfactory coding.

Award Number: R01DC013779

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2015

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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