Tuesday, April 23, 2024 4/23/2024

Early Detection and Treatment of Emerging Cognitive-Linguistic Impairment in Minority Cognitive Aging and Primary Progressive Aphasia

Award Number: R01DC013063
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

PROJECT SUMMARY/ABSTRACT Dementia is among the most daunting public health crises facing industrialized nations. Many countries, including the United States,1 have recently adopted comprehensive national dementia strategies.2 The US National Dementia Strategy (section 2B) has identified early diagnosis and links to community treatment services as pillars of its management plan. The availability of evidence-based outpatient treatment for progressive language impairments remains exceedingly sparse. In 2014, we began to address this void via a longitudinal intervention targeting maintenance of a core vocabulary consisting of 100 words over two years. This caregiver-friendly treatment is showing great promise for promoting the retention of key vocabulary in frontotemporal degeneration and Alzheimer's Disease. A secondary aim involved evaluating prediction of later language forgetting. We have learned much during this initial project period, and its renewal has the potential to tell us much more. Our current proposal consists of three aims, all of which directly align both with the US National Dementia Strategy and the mission of our funding institute (i.e., the National Institute on Deafness and Other Communication Disorders).3 In Specific Aim 1 (SA1), we will evaluate the long-term effectiveness of a regimen of noninvasive brain stimulation (transcranial direct current stimulation) delivered over the anterior temporal lobes as an adjuvant to our ongoing semantic behavioral treatment. We will do so using a crossover design where two groups of patients with semantic variant Primary Progressive Aphasia complete sham and active stimulation conditions paired with behavioral treatment (order counterbalanced). We will subsequently follow this patient cohort over two years to evaluate the durability of treatment gains. In SA2, we will evaluate predictors of emerging cognitive-linguistic impairment in a vastly underserved population (i.e., older African American adults). We will identify older adults who are at increased risk for conversion to mild cognitive impairment as indexed by global cognitive and language measures. We will then follow and characterize this prospective cohort using sensitive behavioral (gaze patterns during visual confrontation naming) and neuropsychological markers. Finally, in SA3 we will evaluate representation, processing, and shifts in abstract word meaning as functions of age, pathology, and individual differences (e.g., vocabulary size, years of education) using machine learning. This renewal reflects the continuation of a productive and rigorous line of research that will yield complementary data about human semantic memory, best practices in promoting language maintenance, and variability of age-associated language change.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $588,588 )
2024	2024	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	11	1/31/2024	COMPETING CONTINUATION	$588,588
														Subtotal = $588,588

Issue Date FY: 2023 ( Subtotal = $297,379 )
2023	2023	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	10	1/12/2023	NON-COMPETING CONTINUATION	$297,379
														Subtotal = $297,379

Issue Date FY: 2022 ( Subtotal = $470,150 )
2022	2022	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	9	4/22/2022	NON-COMPETING CONTINUATION	$46,739
2022	2022	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	9	1/7/2022	NON-COMPETING CONTINUATION	$420,650
2022	2018	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	5	9/26/2022	NON-COMPETING CONTINUATION	$2,761
														Subtotal = $470,150

Issue Date FY: 2021 ( Subtotal = $470,083 )
2021	2021	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	8	1/15/2021	NON-COMPETING CONTINUATION	$470,083
														Subtotal = $470,083

Issue Date FY: 2020 ( Subtotal = $466,715 )
2020	2020	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	7	3/4/2020	NON-COMPETING CONTINUATION	$466,715
2020	2019	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	6	12/12/2019	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $466,715

Issue Date FY: 2019 ( Subtotal = $827,402 )
2019	2019	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	004	6	7/17/2019	COMPETING CONTINUATION	$85,034
2019	2019	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	6	6/18/2019	SUPPLEMENT FOR EXPANSION	$388,791
2019	2019	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	6	6/11/2019	COMPETING CONTINUATION	$0
2019	2019	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	6	1/15/2019	COMPETING CONTINUATION	$438,611
2019	2018	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	003	5	7/17/2019	NON-COMPETING CONTINUATION	-$85,034
														Subtotal = $827,402

Issue Date FY: 2018 ( Subtotal = $473,526 )
2018	2018	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	5	4/5/2018	NON-COMPETING CONTINUATION	$47,353
2018	2018	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	5	1/25/2018	NON-COMPETING CONTINUATION	$426,173
														Subtotal = $473,526

Issue Date FY: 2017 ( Subtotal = $476,706 )
2017	2017	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	4	1/6/2017	NON-COMPETING CONTINUATION	$429,035
2017	2017	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	4	5/24/2017	NON-COMPETING CONTINUATION	$47,671
														Subtotal = $476,706

Issue Date FY: 2016 ( Subtotal = $479,766 )
2016	2016	TEMPLE UNIVERSITY	BROAD & MONTGOMERY AVENUE	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	3	2/25/2016	NON-COMPETING CONTINUATION	$479,766
														Subtotal = $479,766

Issue Date FY: 2015 ( Subtotal = $469,379 )
2015	2015	TEMPLE UNIVERSITY	BROAD & MONTGOMERY AVENUE	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	2	1/23/2015	NON-COMPETING CONTINUATION	$469,379
														Subtotal = $469,379

Issue Date FY: 2014 ( Subtotal = $516,827 )
2014	2014	TEMPLE UNIVERSITY	BROAD & MONTGOMERY AVENUE	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	1	1/30/2014	NEW	$516,827
														Subtotal = $516,827

Grand Total All Awards = $5,536,521

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Early Detection and Treatment of Emerging Cognitive-Linguistic Impairment in Minority Cognitive Aging and Primary Progressive Aphasia

Award Number: R01DC013063

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer