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Synaptic basis of perceptual learning with cochlear implants in rat auditory cortex - Renewal

Award Number: R01DC012557
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Synaptic basis of perceptual learning with cochlear implants in rat auditory cortex - Renewal - Project Summary The brain has the remarkable capability to change in response to experience. This plasticity is essential for learning and memory, and is an important feature of the auditory cortex, especially for learning the significance of sensory signals such as speech, recovery after short-term deafness, and the use of devices such as cochlear implants for hearing restoration. These changes are thought to occur primarily at synapses, basic units of information processing and plasticity. Long-term synaptic plasticity requires sensory experience and activation of neuromodulatory systems which convey behavioral context to local cortical circuits. It is generally believed that these mechanisms are important for initial adaptation and performance with cochlear implants. However, little is known about how single neurons and circuits of the auditory system are modified during cochlear implant training to support performance, or how these mechanisms might be leveraged to improve hearing restoration. Over the last decade, the Froemke and Svirsky labs at NYU School of Medicine have been collaborating with the NYU Department of Otolaryngology and Cochlear Americas to examine unilateral multi-channel implant use in bilaterally profoundly-deafened rats. Rats are ideal for studying the neuroscience of neuroprosthetic use, as we can monitor neurophysiological changes in highly-trained rats reporting auditory percepts, recording in behaving animals to measure single-trial neural correlates and longer-term forms of neuroplasticity over days to weeks of implant use. Furthermore, we can take advantage of recent advances in optogenetics and imaging technologies in transgenic rat lines, to monitor and manipulate neural activity in specific brain regions and in select cell populations. We have found that implanted rats show analogous variable individual performance and learning rates as with human subjects. In our prior publications supporting the proposed experiments, we found that response levels and tuning curves in auditory cortex related to individual rat performance. We also found that activity in the brainstem locus coeruleus- a major source of the modulator noradrenalin- could predict when rats would begin performing well with implant stimulation, and that optogenetic stimulation of locus coeruleus produced high levels of performance in all animals. This indicates that neuromodulation and cortical plasticity are predictive biomarkers and potential avenues for improving performance with cochlear implants. Here in Aim 1 we make µ-electrocorticography and single-unit recordings as rats learn to use cochlear implants to perform an auditory 2-alternative forced-choice task; we will monitor larger-scale cortical cochleotopy and single neuron responses on individual trials during implant training. In Aim 2, we use whole-cell recordings in vivo ask how cortical inhibition shapes cortical responses and regulates plasticity for cortical implant learning. In Aim 3, we ask how cholinergic and noradrenergic modulatory systems respond during implant training and could be stimulated to improve implant use.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $604,873 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	13	11/19/2024	NON-COMPETING CONTINUATION	$604,873
														Subtotal = $604,873

Issue Date FY: 2024 ( Subtotal = $672,080 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	003	12	5/7/2024	NON-COMPETING CONTINUATION	$67,207
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	002	12	11/14/2023	NON-COMPETING CONTINUATION	$604,873
2024	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	11	11/7/2023	COMPETING CONTINUATION	$95,196
2024	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	10	11/7/2023	NON-COMPETING CONTINUATION	-$95,196
														Subtotal = $672,080

Issue Date FY: 2023 ( Subtotal = $672,080 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	11	11/28/2022	COMPETING CONTINUATION	$672,080
														Subtotal = $672,080

Issue Date FY: 2022 ( Subtotal = $387,314 )
2022	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	10	4/19/2022	NON-COMPETING CONTINUATION	$38,731
2022	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	10	11/22/2021	NON-COMPETING CONTINUATION	$348,583
														Subtotal = $387,314

Issue Date FY: 2021 ( Subtotal = $387,314 )
2021	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	9	1/7/2021	NON-COMPETING CONTINUATION	$38,731
2021	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	9	11/24/2020	NON-COMPETING CONTINUATION	$348,583
														Subtotal = $387,314

Issue Date FY: 2020 ( Subtotal = $482,020 )
2020	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	002	8	1/15/2020	NON-COMPETING CONTINUATION	$36,959
2020	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	8	11/13/2019	SUPPLEMENT FOR EXPANSION	$112,428
2020	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	8	11/12/2019	NON-COMPETING CONTINUATION	$332,633
														Subtotal = $482,020

Issue Date FY: 2019 ( Subtotal = $378,453 )
2019	2019	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	7	11/27/2018	NON-COMPETING CONTINUATION	$378,453
														Subtotal = $378,453

Issue Date FY: 2018 ( Subtotal = $418,788 )
2018	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	6	12/20/2017	COMPETING CONTINUATION	-$2,674
2018	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	004	6	4/10/2018	COMPETING CONTINUATION	$45,341
2018	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	6	12/6/2017	COMPETING CONTINUATION	$389,988
2018	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	002	6	1/25/2018	SUPPLEMENT FOR EXPANSION	$31,474
2018	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	003	5	4/10/2018	NON-COMPETING CONTINUATION	-$45,341
														Subtotal = $418,788

Issue Date FY: 2017 ( Subtotal = $448,005 )
2017	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	5	11/2/2016	NON-COMPETING CONTINUATION	$403,204
2017	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	5	5/24/2017	NON-COMPETING CONTINUATION	$44,801
														Subtotal = $448,005

Issue Date FY: 2016 ( Subtotal = $462,580 )
2016	2016	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	4	10/28/2015	EXTENSION WITH OR WITHOUT FUNDS	$380,250
2016	2016	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	4	1/22/2016	SUPPLEMENT FOR EXPANSION	$40,080
2016	2016	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	002	4	1/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$42,250
														Subtotal = $462,580

Issue Date FY: 2015 ( Subtotal = $450,354 )
2015	2015	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	3	1/21/2015	NON-COMPETING CONTINUATION	$40,999
2015	2015	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	3	11/6/2014	NON-COMPETING CONTINUATION	$409,355
														Subtotal = $450,354

Issue Date FY: 2014 ( Subtotal = $455,703 )
2014	2014	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	002	2	4/3/2014	SUPPLEMENT FOR EXPANSION	$42,373
2014	2014	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	2	2/5/2014	NON-COMPETING CONTINUATION	$41,333
2014	2014	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	2	11/14/2013	NON-COMPETING CONTINUATION	$371,997
														Subtotal = $455,703

Issue Date FY: 2013 ( Subtotal = $412,809 )
2013	2013	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	1	11/29/2012	NEW	$412,809
														Subtotal = $412,809

Grand Total All Awards = $6,232,373

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Synaptic basis of perceptual learning with cochlear implants in rat auditory cortex - Renewal

Award Number: R01DC012557

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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