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Specifying the Short-term Verbal Memory Endophenotype for Developmental Language Disorder

Award Number: R01DC011742
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/23/2012
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Specifying the Short-term Verbal Memory Endophenotype for Developmental Language Disorder - PROJECT SUMMARY/ABSTRACT Because this project addresses the mechanisms that contribute to Developmental Language Disorder (DLD), a highly prevalent communication disorder in the United States, it is directly relevant to the mission of NIDCD. Ultimately, the outcomes may offer solutions to three significant problems: how to identify DLD regardless of language(s) spoken, how to identify DLD in adults, and how to distinguish DLD from other related conditions. Our overarching hypothesis is that a deficit in short-term verbal memory (stVM) is endophenotypic of DLD. Our current objectives are to 1) delineate the role of linguistic long-term memory, attention, and their interface in the stVM deficit and 2) demonstrate the cascading effects of the stVM deficit on the integrity of the language system. Aim 1: To determine the contribution of structure and meaning in linguistic long-term memory to the stVM deficit. We will manipulate prosodic structure and word meaning during nonword repetition (NWR) (1a) and grammatical structure during real phrase repetition (1b) and use linear mixed-effects models to test the hypothesis that individuals with DLD can use linguistic long-term memory to support stVM, but they benefit more from meaning than structure. 1b also offers a chance to explore the nature of stVM per se, specifically, to observe the children’s rehearsal strategies. Aim 2: To determine the contribution of attention to the stVM deficit. We will manipulate the burden on attention during encoding by pairing a visual search task with the NWR of sequences with high or low phonotactic probability and use linear mixed-effects models to test the hypothesis that the stVM deficit reflects difficulties in attentional control during encoding. This experiment also offers an additional test of the contribution of linguistic long-term memory to stVM function. Aim 3: To determine the relationship between sustained attention, stVM, and linguistic long-term memory. We will conduct two tests of each construct and use principal component analysis and multiple regression to test the hypothesis that language moderates the relationship between sustained attention and stVM. Aim 4: To simulate the cascading effect of the stVM deficits. To test the stVM deficit as an endophenotype, we will provide higher and lower support for novel word form encoding in children with typical language development and observe the subsequent influence on two aspects of the system, semantic category knowledge and sentence comprehension. We will use linear mixed-effects models to test the hypothesis that the stVM deficit has downstream consequences for the integrity of the overall language system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $601,854 )
2025	2025	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	12	6/13/2025	NON-COMPETING CONTINUATION	$601,854
														Subtotal = $601,854

Issue Date FY: 2024 ( Subtotal = $604,476 )
2024	2024	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	001	11	6/25/2024	COMPETING CONTINUATION	$604,476
2024	2021	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	10	1/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $604,476

Issue Date FY: 2021 ( Subtotal = $475,771 )
2021	2021	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	10	6/23/2021	NON-COMPETING CONTINUATION	$475,771
														Subtotal = $475,771

Issue Date FY: 2020 ( Subtotal = $441,767 )
2020	2020	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	9	6/16/2020	NON-COMPETING CONTINUATION	$441,767
														Subtotal = $441,767

Issue Date FY: 2019 ( Subtotal = $482,969 )
2019	2019	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	8	6/25/2019	NON-COMPETING CONTINUATION	$482,969
														Subtotal = $482,969

Issue Date FY: 2018 ( Subtotal = $488,634 )
2018	2018	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	000	7	6/21/2018	NON-COMPETING CONTINUATION	$488,634
														Subtotal = $488,634

Issue Date FY: 2017 ( Subtotal = $501,858 )
2017	2017	FATHER FLANAGAN'S BOY'S HOME INC	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	001	6	6/21/2017	COMPETING CONTINUATION	$501,858
2017	2017	FATHER FLANAGAN'S BOY'S HOME INC	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Research Related to Deafness and Communication Disorders	003	6	8/3/2017	COMPETING CONTINUATION	$2,723
2017	2016	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	5	6/21/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2016	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	002	5	8/3/2017	EXTENSION WITH OR WITHOUT FUNDS	-$2,723
														Subtotal = $501,858

Issue Date FY: 2016 ( Subtotal = $400,538 )
2016	2016	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	5	1/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$40,055
2016	2016	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	5	12/22/2015	EXTENSION WITH OR WITHOUT FUNDS	$360,483
														Subtotal = $400,538

Issue Date FY: 2015 ( Subtotal = $399,074 )
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	4	1/13/2015	NON-COMPETING CONTINUATION	$36,280
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	4	12/19/2014	NON-COMPETING CONTINUATION	$362,794
														Subtotal = $399,074

Issue Date FY: 2014 ( Subtotal = $404,389 )
2014	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	3	12/13/2013	NON-COMPETING CONTINUATION	$363,949
2014	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	3	2/10/2014	NON-COMPETING CONTINUATION	$40,440
														Subtotal = $404,389

Issue Date FY: 2013 ( Subtotal = $382,653 )
2013	2013	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	2	5/16/2013	NON-COMPETING CONTINUATION	$22,169
2013	2013	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	2	12/21/2012	NON-COMPETING CONTINUATION	$360,484
														Subtotal = $382,653

Issue Date FY: 2012 ( Subtotal = $406,956 )
2012	2012	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	1	1/20/2012	NEW	$406,956
														Subtotal = $406,956

Grand Total All Awards = $5,590,939

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Specifying the Short-term Verbal Memory Endophenotype for Developmental Language Disorder

Award Number: R01DC011742

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/23/2012

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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