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Determining the Impact of Swallowing Impairment in People recovering from Severe COVID-19 Infection

Award Number: R01DC011020
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract The recent spread of COVID-19 has led to an international pandemic, with >4 million confirmed cases to date worldwide, of which >1.3 million confirmed cases and >80,000 deaths have been reported in the USA. Infected individuals commonly experience severe respiratory difficulties and pneumonia, leading to hospital admission and the need for intensive care and mechanical ventilation. Emerging evidence suggests that impaired taste and smell may be early markers of the disease, and that in severe cases, there may be neurological damage in in the medulla, an important brainstem control site for both respiration and swallowing. Given the overlapping neuroanatomical regulation of breathing and swallowing, we hypothesize that dysphagia (swallowing impairment) will be common in People recovering from Severe COVID-19 (PrSC-19) and associated with poorer outcomes. Through this grant supplement, we propose to extend our existing work characterizing dysphagia profiles in different clinical populations to study dysphagia and its impact in PrSC- 19. To understand the prevalence and pathophysiology of dysphagia in PrSC-19, we will conduct detailed analyses of videofluoroscopies performed during the standard of care, post-discharge from intensive care to regular medical care units within the acute care setting. Given the current limitations in performing swallowing assessments for inpatients who test positive for COVID-19, we will also establish 3 regional research clinics that will offer comprehensive swallowing assessments to PrSC-19 after discharge from acute care to rehabilitation or the community. These assessments will include the collection of case history information, videofluoroscopy, use of a novel digital stethoscope to measure respiratory-swallow coordination, measures of other risk factors for dysphagia (e.g. bulbar muscle strength) and patient-reported outcomes. Detailed analyses of the videofluoroscopies will identify specific measures of swallowing that fall outside the range of normal variation based on comparison to healthy reference values established through our research program exploring swallowing physiology on liquids of different consistencies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON			CAN	Research Related to Deafness and Communication Disorders	000	8	5/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON			CAN	Research Related to Deafness and Communication Disorders	000	8	1/8/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $456,649 )
2020	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	001	8	8/11/2020	SUPPLEMENT FOR EXPANSION	$135,000
2020	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	000	8	2/21/2020	NON-COMPETING CONTINUATION	$321,649
														Subtotal = $456,649

Issue Date FY: 2019 ( Subtotal = $461,764 )
2019	2019	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	000	7	3/14/2019	NON-COMPETING CONTINUATION	$461,764
														Subtotal = $461,764

Issue Date FY: 2018 ( Subtotal = $460,394 )
2018	2018	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	000	6	2/20/2018	NON-COMPETING CONTINUATION	$414,355
2018	2018	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	001	6	4/4/2018	NON-COMPETING CONTINUATION	$46,039
														Subtotal = $460,394

Issue Date FY: 2017 ( Subtotal = $446,726 )
2017	2017	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	001	5	5/24/2017	NON-COMPETING CONTINUATION	$44,673
2017	2017	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	000	5	2/15/2017	NON-COMPETING CONTINUATION	$402,053
														Subtotal = $446,726

Issue Date FY: 2016 ( Subtotal = $457,693 )
2016	2016	UNIVERSITY HEALTH NETWORK	190 Elizabeth Street	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	4	2/17/2016	COMPETING CONTINUATION	$457,693
														Subtotal = $457,693

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2012	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVENUE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	3	4/30/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $186,485 )
2012	2012	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	3	7/17/2012	NON-COMPETING CONTINUATION	$186,485
														Subtotal = $186,485

Issue Date FY: 2011 ( Subtotal = $204,388 )
2011	2011	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	2	7/18/2011	NON-COMPETING CONTINUATION	$204,388
														Subtotal = $204,388

Issue Date FY: 2010 ( Subtotal = $262,141 )
2010	2010	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVENUE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	001	1	8/20/2010	NEW	$0
2010	2010	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	1	7/23/2010	NEW	$262,141
														Subtotal = $262,141

Grand Total All Awards = $2,936,240

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Determining the Impact of Swallowing Impairment in People recovering from Severe COVID-19 Infection

Award Number: R01DC011020

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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