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Determining the Impact of Swallowing Impairment in People recovering from Severe COVID-19 Infection

Award Number: R01DC011020
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (provided by applicant): The practice of thickening liquids has become one of the most frequently used interventions for swallowing impairment (dysphagia). However, the terminology used to describe thickened liquids (such as nectar-thick and honey-thick) is subjective and we lack empirical evidence about how alterations in liquid consistency affect swallowing function and physiology. The International Dysphagia Diet Standardisation Initiative is a multidisciplinary task force (www.iddsi.org) that has recently developed a new taxonomy of terms to label different levels of liquid consistency used in dysphagia management; these are paired with operational definitions and practical gravity-flow measurement techniques that can be used by caregivers and clinicians to confirm the category of any liquid at the time of preparation or serving. The goal of the current proposal is to measure the in vitro physiological flow of liquids representative of the IDDSI levels of liquid consistency (thin, slightly-thick, milly-thick, moderately-thick and extremely-thick). Physiological measures of liquid flow require an understanding both of the rheological properties of the liquid (gravity-flow; viscosity) and the forces that are applied to the liquid during swallowing (tongue pressure; swallowing muscle contraction). Additional sensory attributes of the bolus (such as slipperiness, graininess and cohesiveness) are also likely to be relevant. We will measure these properties and study bolus flow in healthy adults to establish a reference perspective of expected flow in the context of healthy tongue pressure generation. We will then collect comparative measures in individuals with dysphagia of different etiologies (stroke, acquired brain injury, oropharyngeal cancer, post cervical spine surgery, and neurodegenerative disease) to determine how alterations in swallowing motor function impact liquid flow. These measurements will provide information to guide clinicians in determining optimal levels of thickening to recommend for patients with dysphagia. This research is highly significant because it will establish a new foundation of understanding with respect to the influence of thickened liquids on swallowing. This is essential for advancing clinical practice and setting the stage for future treatment efficacy research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$99,780 )
2025	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON			CAN	Research Related to Deafness and Communication Disorders	000	8	10/1/2024	SUPPLEMENT FOR EXPANSION	-$99,780
														Subtotal = -$99,780

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON			CAN	Research Related to Deafness and Communication Disorders	000	8	5/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON			CAN	Research Related to Deafness and Communication Disorders	000	8	1/8/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $456,649 )
2020	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	001	8	8/11/2020	SUPPLEMENT FOR EXPANSION	$135,000
2020	2020	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	000	8	2/21/2020	NON-COMPETING CONTINUATION	$321,649
														Subtotal = $456,649

Issue Date FY: 2019 ( Subtotal = $461,764 )
2019	2019	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	000	7	3/14/2019	NON-COMPETING CONTINUATION	$461,764
														Subtotal = $461,764

Issue Date FY: 2018 ( Subtotal = $460,394 )
2018	2018	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	000	6	2/20/2018	NON-COMPETING CONTINUATION	$414,355
2018	2018	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	001	6	4/4/2018	NON-COMPETING CONTINUATION	$46,039
														Subtotal = $460,394

Issue Date FY: 2017 ( Subtotal = $446,726 )
2017	2017	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	001	5	5/24/2017	NON-COMPETING CONTINUATION	$44,673
2017	2017	UNIVERSITY HEALTH NETWORK	200 ELIZABETH ST	TORONTO	ON	M5G 2C4		CAN	Research Related to Deafness and Communication Disorders	000	5	2/15/2017	NON-COMPETING CONTINUATION	$402,053
														Subtotal = $446,726

Issue Date FY: 2016 ( Subtotal = $457,693 )
2016	2016	UNIVERSITY HEALTH NETWORK	190 Elizabeth Street	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	4	2/17/2016	COMPETING CONTINUATION	$457,693
														Subtotal = $457,693

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2012	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVENUE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	3	4/30/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $186,485 )
2012	2012	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	3	7/17/2012	NON-COMPETING CONTINUATION	$186,485
														Subtotal = $186,485

Issue Date FY: 2011 ( Subtotal = $204,388 )
2011	2011	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	2	7/18/2011	NON-COMPETING CONTINUATION	$204,388
														Subtotal = $204,388

Issue Date FY: 2010 ( Subtotal = $262,141 )
2010	2010	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVENUE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	001	1	8/20/2010	NEW	$0
2010	2010	TORONTO REHABILITATION INSTITUTE	550 UNIVERSITY AVE	TORONTO				CAN	Research Related to Deafness and Communication Disorders	000	1	7/23/2010	NEW	$262,141
														Subtotal = $262,141

Grand Total All Awards = $2,836,460

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Determining the Impact of Swallowing Impairment in People recovering from Severe COVID-19 Infection

Award Number: R01DC011020

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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