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Imaging and influence of glottic and subglottic anatomy in healthy and stenotic patients

Award Number: R01DC009616
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2009
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Imaging and influence of glottic and subglottic anatomy in healthy and stenotic patients - SUMMARY Upper airway stenosis is a condition that significantly impairs breathing and voice. Stenosis-related voice disorders can adversely impact communication, job performance, psychosocial function, and quality of life. Clinical and scientific studies have elucidated important relationships between voice function and stenosis severity and management, but many aspects of these relationships are not fully understood. The objectives of the proposed research are to develop larynx-specific MRI coils and protocols for upper airway stenosis imaging and to determine the impact of glottic and subglottic morphology on voice function in upper airway stenosis patients. Custom imaging coils and protocols will be developed and refined based on physical principles and preliminary tests. MR images in stenosis patients will be acquired pre- and post-operatively. Images will be used to create 3D geometric models for morphometric analysis and posting on an online laryngeal data repository for further research. Retrospective and prospective pre- and post-operative aerodynamic and acoustic studies of patients with upper airway stenosis will be conducted to explore relationships between preoperative voice complaints and pre/post-operative voice changes. Excised larynx and synthetic vocal fold laboratory experiments using 3D-printed airways with adjustable stenoses, in conjunction with complementary computational simulations of phonatory flow-structure-acoustic interactions, will be used to explore fundamental physical relationships between stenosis geometry and changes in flow patterns, vocal fold vibration, and acoustics. Anticipated outcomes include larynx imaging coil prototypes and protocols suitable for the needs of clinical laryngeal imaging evaluations and scientific research, detailed geometric three-dimensional models of the upper airway in healthy and stenosis populations, and deeper insight into the sources of dysphonia in stenosis patients and into the aerodynamic and acoustical changes associated with upper airway stenosis. The ultimate aim is to develop tools and understanding that will lead to improved voice outcomes for patients with upper airway stenosis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Research Related to Deafness and Communication Disorders	001	11	10/12/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$594,194
2024	2022	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Research Related to Deafness and Communication Disorders	004	11	8/12/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2022	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Research Related to Deafness and Communication Disorders	003	11	6/24/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$150,386
2024	2022	BRIGHAM YOUNG UNIVERSITY	A-153 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	10	10/12/2023	NON-COMPETING CONTINUATION	-$594,194
2024	2021	BRIGHAM YOUNG UNIVERSITY	A-153 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	002	9	6/24/2024	NON-COMPETING CONTINUATION	-$150,386
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $594,194 )
2022	2022	BRIGHAM YOUNG UNIVERSITY	A41 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	10	8/17/2022	NON-COMPETING CONTINUATION	$594,194
														Subtotal = $594,194

Issue Date FY: 2021 ( Subtotal = $594,194 )
2021	2021	BRIGHAM YOUNG UNIVERSITY	A41 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	9	8/25/2021	NON-COMPETING CONTINUATION	$594,194
														Subtotal = $594,194

Issue Date FY: 2020 ( Subtotal = $609,144 )
2020	2020	BRIGHAM YOUNG UNIVERSITY	A41 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	001	8	8/14/2020	NON-COMPETING CONTINUATION	$606,141
2020	2018	BRIGHAM YOUNG UNIVERSITY	A41 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	6	11/12/2019	COMPETING CONTINUATION	$3,003
														Subtotal = $609,144

Issue Date FY: 2019 ( Subtotal = $617,903 )
2019	2019	BRIGHAM YOUNG UNIVERSITY	A-41 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	002	7	8/19/2019	NON-COMPETING CONTINUATION	$533,417
2019	2018	BRIGHAM YOUNG UNIVERSITY	A-41 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	6	4/10/2019	COMPETING CONTINUATION	$0
2019	2018	BRIGHAM YOUNG UNIVERSITY	A-41 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	001	6	4/10/2019	COMPETING CONTINUATION	$84,486
														Subtotal = $617,903

Issue Date FY: 2018 ( Subtotal = $663,696 )
2018	2018	BRIGHAM YOUNG UNIVERSITY	A-41 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	6	6/1/2018	COMPETING CONTINUATION	$663,696
														Subtotal = $663,696

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2013	BRIGHAM YOUNG UNIVERSITY	D-177 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	5	7/3/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $290,126 )
2013	2013	BRIGHAM YOUNG UNIVERSITY	D-177 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	5	6/17/2013	NON-COMPETING CONTINUATION	$290,126
														Subtotal = $290,126

Issue Date FY: 2012 ( Subtotal = $333,551 )
2012	2012	BRIGHAM YOUNG UNIVERSITY	D-177 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	4	6/18/2012	NON-COMPETING CONTINUATION	$333,551
														Subtotal = $333,551

Issue Date FY: 2011 ( Subtotal = $336,363 )
2011	2011	BRIGHAM YOUNG UNIVERSITY	D-177 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	3	6/20/2011	NON-COMPETING CONTINUATION	$336,363
														Subtotal = $336,363

Issue Date FY: 2010 ( Subtotal = $393,153 )
2010	2010	BRIGHAM YOUNG UNIVERSITY	D-177 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	2	6/18/2010	NON-COMPETING CONTINUATION	$393,153
														Subtotal = $393,153

Issue Date FY: 2009 ( Subtotal = $422,076 )
2009	2009	BRIGHAM YOUNG UNIVERSITY	D-177 ASB	PROVO	UT	84602	UTAH	USA	Research Related to Deafness and Communication Disorders	000	1	6/29/2009	NEW	$422,076
														Subtotal = $422,076

Grand Total All Awards = $4,854,400

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Imaging and influence of glottic and subglottic anatomy in healthy and stenotic patients

Award Number: R01DC009616

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2009

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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