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The Relationship Between Vortices, Acoustics, and Vibration in Vocal Fold Asymmetries

Award Number: R01DC009435
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The Relationship Between Vortices, Acoustics, and Vibration in Vocal Fold Asymmetries - Project summary. Common operations for unilateral vocal fold paralysis (UVFP), such as Thyroplasty Type 1, improve vocal efficiency (VE) by closing the membranous gap between the normal and paralyzed fold. VE measures the degree to which subglottal aerodynamic power is translated to acoustic power. However, even after surgical treatment, some patients report symptoms such as vocal fatigue, decreased projection, and decreased intelligibility in noisy environments. These recalcitrant symptoms will be associated with reduced VE relative to normal voice, suggesting that enhancing VE could further ameliorate these symptoms. Our previous work in the excised canine larynx suggests that this further improvement is possible by certain modifications to the procedure. For example, we found the surprising result that medialization of the tissue below the fold (infraglottal region) results in higher VE than medialization of the fold itself (glottal) even though both operations close the medial-lateral membranous gap. Additionally, inclusion of arytenoid adduction increased VE relative to infraglottal medialization alone. However, to translate these surgical findings in animals to patients requires a deeper understanding about how and why various treatment modifications affect VE. In prior work we found that rotational motion (vortices) occur between the folds during closing. These vortices produce negative pressures that cause the folds to close together faster, which increase acoustic intensity and VE. We know that the bottom part of the folds is stiffer than the upper part; this is referred to as the vertical stiffness gradient (VSG). We have also found that lower VSG produces weaker vortices and decreased VE. In the first aim, we will further examine the effect of the VSG on VE. In the second and third aim, we will look at how and why different treatments for UVFP affect VE. This application lays the foundation for using VE clinically, and for optimizing clinical treatments for UVFP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $629,761 )
2025	2025	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	001	15	4/21/2025	NON-COMPETING CONTINUATION	$62,977
2025	2025	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	15	3/20/2025	NON-COMPETING CONTINUATION	$566,784
														Subtotal = $629,761

Issue Date FY: 2024 ( Subtotal = $638,373 )
2024	2024	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	14	4/1/2024	NON-COMPETING CONTINUATION	$638,373
														Subtotal = $638,373

Issue Date FY: 2023 ( Subtotal = $647,242 )
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	001	13	3/24/2023	NON-COMPETING CONTINUATION	$647,242
2023	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	12	2/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $647,242

Issue Date FY: 2022 ( Subtotal = $611,450 )
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	12	4/27/2022	NON-COMPETING CONTINUATION	$611,450
														Subtotal = $611,450

Issue Date FY: 2021 ( Subtotal = $632,470 )
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	11	4/9/2021	COMPETING CONTINUATION	$632,470
2021	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	001	10	9/16/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $632,470

Issue Date FY: 2019 ( Subtotal = $598,096 )
2019	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	10	2/20/2019	NON-COMPETING CONTINUATION	$598,096
														Subtotal = $598,096

Issue Date FY: 2018 ( Subtotal = $613,875 )
2018	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	9	2/16/2018	NON-COMPETING CONTINUATION	$552,489
2018	2018	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	001	9	4/5/2018	NON-COMPETING CONTINUATION	$61,386
														Subtotal = $613,875

Issue Date FY: 2017 ( Subtotal = $576,805 )
2017	2017	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	8	2/14/2017	NON-COMPETING CONTINUATION	$519,124
2017	2017	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Research Related to Deafness and Communication Disorders	001	8	5/24/2017	NON-COMPETING CONTINUATION	$57,681
														Subtotal = $576,805

Issue Date FY: 2016 ( Subtotal = $579,410 )
2016	2016	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	001	7	2/26/2016	NON-COMPETING CONTINUATION	$579,410
2016	2015	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	452210225	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	6	11/12/2015	COMPETING CONTINUATION	$0
														Subtotal = $579,410

Issue Date FY: 2015 ( Subtotal = $553,286 )
2015	2015	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	6	3/19/2015	COMPETING CONTINUATION	$513,803
2015	2015	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	002	6	8/21/2015	SUPPLEMENT FOR EXPANSION	$39,483
2015	2013	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	001	5	3/19/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $553,286

Issue Date FY: 2013 ( Subtotal = $370,627 )
2013	2013	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	5	8/20/2013	NON-COMPETING CONTINUATION	$370,627
														Subtotal = $370,627

Issue Date FY: 2012 ( Subtotal = $402,329 )
2012	2012	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	4	8/7/2012	NON-COMPETING CONTINUATION	$402,329
														Subtotal = $402,329

Issue Date FY: 2011 ( Subtotal = $394,655 )
2011	2011	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	3	8/15/2011	NON-COMPETING CONTINUATION	$394,655
														Subtotal = $394,655

Issue Date FY: 2010 ( Subtotal = $617,119 )
2010	2010	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	2	8/16/2010	NON-COMPETING CONTINUATION	$617,119
														Subtotal = $617,119

Issue Date FY: 2009 ( Subtotal = $618,343 )
2009	2009	UNIVERSITY OF CINCINNATI	PO BOX 210225	CINCINNATI	OH	45221	HAMILTON	USA	Research Related to Deafness and Communication Disorders	000	1	9/16/2009	NEW	$618,343
														Subtotal = $618,343

Grand Total All Awards = $8,483,841

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The Relationship Between Vortices, Acoustics, and Vibration in Vocal Fold Asymmetries

Award Number: R01DC009435

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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