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Contribution of striatum to central auditory processing

Award Number: R01DC008983
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2007
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Contribution of striatum to central auditory processing - Project Summary This renewal application will focus on the striatum. It stems from our recent study of the functional contributions of major corticofugal projections from the auditory cortex (ACx). Anatomically receiving convergent cortical and thalamic inputs, the striatum is believed to play an important role in central auditory processing and perception of sound, as evidenced by its involvement in sound-frequency discrimination related behaviors. However, fundamental questions about how specific auditory information is processed, integrated in the striatum, and transformed into appropriate actions remain not well understood. Since the caudal striatum, or the tail of the striatum (TS), receives the highest intensity of ACx projections among all striatal areas, our initial efforts will be centered on the TS, regarded as the “auditory striatum”, to explore its functional role in auditory processing and related behaviors. This proposal builds upon our recent studies on corticostriatal projections from ACx to TS in processing looming sounds, as well as on the mouse cortico-striatal-thalamic network. More importantly, our pilot results suggest that a midbrain structure adjacent to the MGB, known as the nucleus of the brachium of the inferior colliculus (NB in Allen mouse brain atlas, also named “NBIC” or “BIN” in the literature), provides significant bottom-up auditory signals to TS and influences its auditory processing. By exploiting mouse genetic models and combining a suite of cutting-edge approaches such as cell-type- and pathway-specific viral tracing, our recently established AAV1-based anterograde transsynaptic tagging, in vivo and ex vivo electrophysiology, miniscope calcium imaging, as well as optogenetic manipulations, we will test our central hypothesis that TS contributes to auditory spatial processing by integrating binaural information relayed from a unique ascending midbrain-striatal pathway. The proposed project aims to generate new insights into the functional role of striatum in auditory processing perception. Results from this project may help to advance our understanding of the pathophysiology of auditory processing disorders as well as striatum-related neuropsychiatric disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $581,337 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	002	19	8/13/2025	NON-COMPETING CONTINUATION	$581,337
2025	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	18	3/19/2025	COMPETING CONTINUATION	$442,612
2025	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	17	3/19/2025	NON-COMPETING CONTINUATION	-$442,612
														Subtotal = $581,337

Issue Date FY: 2024 ( Subtotal = $628,087 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	18	7/3/2024	COMPETING CONTINUATION	$628,087
														Subtotal = $628,087

Issue Date FY: 2023 ( Subtotal = $554,049 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	17	8/5/2023	NON-COMPETING CONTINUATION	$554,049
														Subtotal = $554,049

Issue Date FY: 2022 ( Subtotal = $554,049 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	16	8/11/2022	NON-COMPETING CONTINUATION	$554,049
														Subtotal = $554,049

Issue Date FY: 2021 ( Subtotal = $554,049 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	15	8/10/2021	NON-COMPETING CONTINUATION	$554,049
														Subtotal = $554,049

Issue Date FY: 2020 ( Subtotal = $554,049 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	003	14	8/13/2020	NON-COMPETING CONTINUATION	$554,049
2020	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	13	1/13/2020	COMPETING CONTINUATION	$206,209
2020	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	002	13	1/16/2020	COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	12	1/13/2020	NON-COMPETING CONTINUATION	-$206,209
														Subtotal = $554,049

Issue Date FY: 2019 ( Subtotal = $617,799 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	13	9/18/2019	COMPETING CONTINUATION	$617,799
2019	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	12	9/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $617,799

Issue Date FY: 2018 ( Subtotal = $412,558 )
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	12	7/12/2018	NON-COMPETING CONTINUATION	$412,558
														Subtotal = $412,558

Issue Date FY: 2017 ( Subtotal = $412,558 )
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	11	7/26/2017	NON-COMPETING CONTINUATION	$412,558
														Subtotal = $412,558

Issue Date FY: 2016 ( Subtotal = $412,558 )
2016	2016	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	10	7/1/2016	NON-COMPETING CONTINUATION	$412,558
														Subtotal = $412,558

Issue Date FY: 2015 ( Subtotal = $408,431 )
2015	2015	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	9	6/29/2015	NON-COMPETING CONTINUATION	$408,431
														Subtotal = $408,431

Issue Date FY: 2014 ( Subtotal = $411,411 )
2014	2014	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	8	6/5/2014	COMPETING CONTINUATION	$411,411
2014	2013	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	7	6/3/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $411,411

Issue Date FY: 2013 ( Subtotal = $122,056 )
2013	2013	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	7	7/17/2013	NON-COMPETING CONTINUATION	$122,056
														Subtotal = $122,056

Issue Date FY: 2012 ( Subtotal = $308,350 )
2012	2012	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	6	7/30/2012	NON-COMPETING CONTINUATION	$308,350
														Subtotal = $308,350

Issue Date FY: 2011 ( Subtotal = $308,350 )
2011	2011	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	5	7/8/2011	NON-COMPETING CONTINUATION	$308,350
														Subtotal = $308,350

Issue Date FY: 2010 ( Subtotal = $318,544 )
2010	2010	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	4	7/28/2010	NON-COMPETING CONTINUATION	$318,544
														Subtotal = $318,544

Issue Date FY: 2009 ( Subtotal = $324,879 )
2009	2009	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	001	3	7/16/2009	NON-COMPETING CONTINUATION	$321,762
2009	2008	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	2	1/13/2009	NON-COMPETING CONTINUATION	$3,117
														Subtotal = $324,879

Issue Date FY: 2008 ( Subtotal = $321,762 )
2008	2008	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	2	7/16/2008	NON-COMPETING CONTINUATION	$321,762
														Subtotal = $321,762

Issue Date FY: 2007 ( Subtotal = $326,000 )
2007	2007	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Research Related to Deafness and Communication Disorders	000	1	6/26/2007	NEW	$326,000
														Subtotal = $326,000

Grand Total All Awards = $8,130,876

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Contribution of striatum to central auditory processing

Award Number: R01DC008983

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2007

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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