Wednesday, December 4, 2024 12/4/2024

Development of the Calyx of Held

Award Number: R01DC007695
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary: A hallmark of developing neural systems is the guidance by spontaneous and experience-driven neural activity for strengthening of some synaptic inputs and pruning of others to define topography of mature neural circuits. We and others have established formation of the calyx of Held (CH) and its innervation of principal neurons (PN) in the medial nucleus of the trapezoid body as a model system to study neural circuit development. We showed that that the CH:PN system, relative to other model systems, has precise onset and short duration of strengthening and pruning to a topographically mature circuit by postnatal day 9, prior to ear canal opening. Preliminary data demonstrates that suppression of spontaneous activity (SA) targeted to the CH:PN synapse prevents key aspects of PN functional maturation. In this proposal we capitalize on this observation to define the functional and structural elements of circuit construction so that we can identify those maturational events that depend on SA. Our research team brings extensive experience with biophysical and physiological properties of this system, which we examine at high (daily) temporal resolution. We leverage our experience with imaging and reconstruction of large electron microscopy volumes to specify global aspects of initial circuit topography along with subcellular detail as a precise structural framework to anchor our observations. We next explore cellular and molecular mechanisms that transmit information about neural activity to maturational programs at high temporal resolution, focused upon activity-dependent Ca2+ entry and phosphorylation of the constitutive transcription factor CREB. These accumulated data can be correlated with better temporal precision than in other model systems to provide deeper insight into causal relationships between SA and maturational events. Errors in early neural circuit specification can result in generalized intellectual and social disabilities, which can have auditory specific phenotypes as in autism spectrum disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $687,951 )
2024	2024	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Research Related to Deafness and Communication Disorders	000	12	3/4/2024	COMPETING CONTINUATION	$687,951
														Subtotal = $687,951

Issue Date FY: 2022 ( Subtotal = -$278 )
2022	2018	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Research Related to Deafness and Communication Disorders	000	11	3/10/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$278
														Subtotal = -$278

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Research Related to Deafness and Communication Disorders	000	11	7/21/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $73,454 )
2019	2018	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Research Related to Deafness and Communication Disorders	003	11	8/5/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$18
2019	2018	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Research Related to Deafness and Communication Disorders	007	11	8/15/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$18
2019	2018	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	10	7/12/2019	NON-COMPETING CONTINUATION	-$358,218
2019	2018	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Research Related to Deafness and Communication Disorders	005	11	8/15/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$18
2019	2018	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	006	10	8/15/2019	NON-COMPETING CONTINUATION	-$18
2019	2018	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Research Related to Deafness and Communication Disorders	001	11	7/12/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$431,672
2019	2009	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE	MORGANTOWN	WV	26506	MONONGALIA	USA	Trans-NIH Recovery Act Research Support	004	3	8/15/2019	SUPPLEMENT FOR EXPANSION	-$18
2019	2009	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE	MORGANTOWN	WV	26506	MONONGALIA	USA	Trans-NIH Recovery Act Research Support	002	3	8/5/2019	SUPPLEMENT FOR EXPANSION	$18
														Subtotal = $73,454

Issue Date FY: 2018 ( Subtotal = $443,249 )
2018	2018	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	10	8/3/2018	NON-COMPETING CONTINUATION	$443,249
														Subtotal = $443,249

Issue Date FY: 2017 ( Subtotal = $443,249 )
2017	2017	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	9	8/18/2017	NON-COMPETING CONTINUATION	$443,249
														Subtotal = $443,249

Issue Date FY: 2016 ( Subtotal = $443,249 )
2016	2016	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	8	8/15/2016	NON-COMPETING CONTINUATION	$443,249
														Subtotal = $443,249

Issue Date FY: 2015 ( Subtotal = $436,955 )
2015	2015	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	7	8/5/2015	NON-COMPETING CONTINUATION	$436,955
														Subtotal = $436,955

Issue Date FY: 2014 ( Subtotal = $465,493 )
2014	2014	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	004	6	8/28/2014	COMPETING CONTINUATION	-$460
2014	2014	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	001	6	5/16/2014	COMPETING CONTINUATION	$465,493
2014	2014	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	002	6	5/20/2014	COMPETING CONTINUATION	$460
2014	2011	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	003	5	5/20/2014	NON-COMPETING CONTINUATION	$0
2014	2011	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	5	5/16/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $465,493

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2011	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	5	6/3/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $266,109 )
2011	2011	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	5	6/6/2011	NON-COMPETING CONTINUATION	$266,109
2011	2009	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Trans-NIH Recovery Act Research Support	001	3	8/24/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $266,109

Issue Date FY: 2010 ( Subtotal = $274,873 )
2010	2010	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	4	4/30/2010	NON-COMPETING CONTINUATION	$274,873
														Subtotal = $274,873

Issue Date FY: 2009 ( Subtotal = $758,518 )
2009	2009	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	3	5/12/2009	NON-COMPETING CONTINUATION	$277,618
2009	2009	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Trans-NIH Recovery Act Research Support	001	3	9/16/2009	SUPPLEMENT FOR EXPANSION	$480,900
														Subtotal = $758,518

Issue Date FY: 2008 ( Subtotal = $282,005 )
2008	2008	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	2	5/6/2008	NON-COMPETING CONTINUATION	$282,005
														Subtotal = $282,005

Issue Date FY: 2007 ( Subtotal = $285,646 )
2007	2007	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	POB 6001, UNIV SVCS CTR #3038B	MORGANTOWN	WV	26506	MONONGALIA	USA	Research Related to Deafness and Communication Disorders	000	1	6/12/2007	NEW	$285,646
														Subtotal = $285,646

Grand Total All Awards = $4,860,473

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Development of the Calyx of Held

Award Number: R01DC007695

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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