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Micromechanical Device for Intracochlear Drug Delivery

Award Number: R01DC006848
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2006
PERIOD OF PERFORMANCE END DATE: 10/31/2016

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Micromechanical Device for Intracochlear Drug Delivery - DESCRIPTION (provided by applicant): Micromechanical Device for Intracochlear Drug Delivery GRANTING NIH INSTITUTE/CENTER: National Institute on Deafness and Other Communication Disorders (NIDCD) GRANT NUMBER: DC006848 ABSTRACT Recent developments in cochlear physiology and molecular biology have paved the way for new and innovative ways of treating and preventing sensorineural hearing loss. These advances will ultimately benefit millions of individuals. However, for this to occur, it will be necessary to develop a safe and reliable mechanism for delivering bioactive compounds directly to the inner ear. The goal of this collaborative research effort is to design and develop a versatile long-term drug delivery system for the treatment of inner ear disorders. Working together, biomedical engineers from Draper Laboratory with experience and expertise in the development of drug delivery microsystems, and clinicians and scientists from the Massachusetts Eye and Ear Infirmary with expertise in inner ear physiology, pharmacology and otologic surgery will engineer, evaluate and perfect a drug delivery system for the treatment of inner ear disorders. This device will have broad application and the potential for revolutionizing the treatment of hearing loss. The design concept includes an implanted device that fits within the mastoid cavity of humans. The device contains an externally-programmable, implanted pump to recirculate perilymph, an intracochlear catheter inserted into the scala tympani, a reservoir and mixing chamber for delivery of concentrated bioactive compounds, and sensors for detecting and transmitting flow and pressure information. The ultra-miniaturized device is a complete, long-term (two year and greater) delivery system, containing therapeutic compound, dispensing mechanism, control electronics, and power supply. Its development takes advantage of recent developments in microfluidics and MEMS (MicroElectroMechanical Systems) technologies. In the previous project period, we developed and tested a microfluidics-based, wearable drug delivery device and demonstrated it in a guinea pig model using a novel reciprocating delivery paradigm. The aims of the renewal proposal are to (1) Develop precision control of drug delivery throughout the cochlea by establishing and demonstrating a computational model that incorporates the fluid dynamic aspects of our drug delivery into previous models of solute kinetics and translates to human clinical applications; (2) Design and build an implantable microfluidic module including a micropump, flow sensor, fluid distribution network and drug reservoir; and (3) Design and build an electronic control and power module and integrate with the microfluidic module from Aim 2, producing a fully implantable prototype for human clinical use with the first application targeted at steroid-responsive autoimmune inner ear disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$2,431 )
2018	2014	CHARLES STARK DRAPER LABORATORY, INC., THE	555 TECHNOLOGY SQ	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	8	11/4/2017	NON-COMPETING CONTINUATION	-$2,431
														Subtotal = -$2,431

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2014	CHARLES STARK DRAPER LABORATORY, INC., THE	555 TECHNOLOGY SQ	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	8	7/31/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2014	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	021393539	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	8	9/27/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $779,558 )
2014	2014	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	8	7/9/2014	NON-COMPETING CONTINUATION	$779,558
														Subtotal = $779,558

Issue Date FY: 2013 ( Subtotal = $743,206 )
2013	2013	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	7	7/2/2013	NON-COMPETING CONTINUATION	$743,206
														Subtotal = $743,206

Issue Date FY: 2012 ( Subtotal = $779,748 )
2012	2012	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	6	7/11/2012	NON-COMPETING CONTINUATION	$779,748
														Subtotal = $779,748

Issue Date FY: 2011 ( Subtotal = $784,241 )
2011	2011	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	5	6/29/2011	NON-COMPETING CONTINUATION	$784,241
														Subtotal = $784,241

Issue Date FY: 2010 ( Subtotal = $784,191 )
2010	2010	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	4	6/7/2010	COMPETING CONTINUATION	$13,826
2010	2010	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	4	5/17/2010	COMPETING CONTINUATION	$770,365
2010	2008	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	002	3	6/10/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $784,191

Issue Date FY: 2008 ( Subtotal = $855,870 )
2008	2008	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	3	2/15/2008	NON-COMPETING CONTINUATION	$855,870
														Subtotal = $855,870

Issue Date FY: 2007 ( Subtotal = $846,655 )
2007	2007	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	2	2/28/2007	NON-COMPETING CONTINUATION	$846,655
														Subtotal = $846,655

Issue Date FY: 2006 ( Subtotal = $862,254 )
2006	2006	Charles Stark Draper Laboratory, Inc.	555 Technology Sq	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	1	3/10/2006	NEW	$862,254
														Subtotal = $862,254

Grand Total All Awards = $6,433,292

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Micromechanical Device for Intracochlear Drug Delivery

Award Number: R01DC006848

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2006

PERIOD OF PERFORMANCE END DATE: 10/31/2016

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