Friday, November 22, 2024 11/22/2024

Amygdala-cortical interactions in taste perception and learning

Award Number: R01DC006666
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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View Award Abstract

The neural system underlying conditioned taste aversion (CTA) is, like all systems underlying perceptual learning, highly complex—learning-relevant regions, most notably including basolateral amygdala (BLA) and gustatory cortex (GC), work together to make learning happen. While most research to date has focused on the role of each individual region in learning, rather than their influence on each other, my lab’s work is a direct investigation of inter-neuronal and inter-regional interactions during taste learning. This work has demonstrated that the coupling between BLA and GC taste responses is important for both basic taste processing and for CTA learning: blocking transmission in the BLAàGC pathway interferes with the coherent emergence of palatability-related information in GC ensemble taste codes (information that appears relatively late in GC responses), and keeps learning from happening; it is therefore reasonable to propose that activity in BLAàGC axons is vital for learning-related plasticity in those GC ensemble responses—that is, in the changes to late-appearing palatability-related coding. The experiments proposed here will build upon this foundation, and on recent work by collaborators, to test this overarching hypothesis. First we will acutely and selectively silence BLAàGC axons, and test whether this perturbation blocks learning- and behavior-linked changes in GC population responses. We will then test whether recently-identified learning-related transcription changes occurring in BLAàGC projection neurons are necessary for the induction and maintenance of GC taste response plasticity caused by CTA. Finally, we will test whether intrinsic excitability in the connection between BLA and GC—which appears to be increased in mice that fail to learn, and decreased in projection neurons that are involved in learning—is the parameter controlling learning-related changes in GC network activity. Together, these experiments will be the first to directly and specifically relate cellular/molecular plasticity processes to the emergent dynamics of network function in vertebrates. In the process, they will reveal new facets of the neural mechanisms of a more general experiential phenomenon that affects (sometimes adversely) all mammals including humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $407,323 )
2024	2024	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	19	3/26/2024	NON-COMPETING CONTINUATION	$407,323
														Subtotal = $407,323

Issue Date FY: 2023 ( Subtotal = $409,033 )
2023	2023	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	18	3/2/2023	NON-COMPETING CONTINUATION	$407,323
2023	2020	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	15	11/23/2022	NON-COMPETING CONTINUATION	$1,710
														Subtotal = $409,033

Issue Date FY: 2022 ( Subtotal = $407,323 )
2022	2022	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	004	17	4/20/2022	NON-COMPETING CONTINUATION	$407,323
2022	2021	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	003	16	1/11/2022	COMPETING CONTINUATION	$113,885
2022	2020	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	002	15	1/11/2022	NON-COMPETING CONTINUATION	-$113,885
2022	2020	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	15	12/10/2021	NON-COMPETING CONTINUATION	$113,885
2022	2020	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	15	12/7/2021	NON-COMPETING CONTINUATION	-$113,885
														Subtotal = $407,323

Issue Date FY: 2021 ( Subtotal = $407,323 )
2021	2021	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	002	16	4/19/2021	COMPETING CONTINUATION	$3,825
2021	2021	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	16	4/9/2021	COMPETING CONTINUATION	$403,498
2021	2020	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	15	4/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $407,323

Issue Date FY: 2020 ( Subtotal = $309,288 )
2020	2020	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	15	1/15/2020	NON-COMPETING CONTINUATION	$30,929
2020	2020	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	15	11/27/2019	NON-COMPETING CONTINUATION	$278,359
														Subtotal = $309,288

Issue Date FY: 2019 ( Subtotal = $309,288 )
2019	2019	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	14	11/7/2018	NON-COMPETING CONTINUATION	$309,288
														Subtotal = $309,288

Issue Date FY: 2018 ( Subtotal = $309,288 )
2018	2018	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	13	11/22/2017	NON-COMPETING CONTINUATION	$278,359
2018	2018	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	13	4/3/2018	NON-COMPETING CONTINUATION	$30,929
														Subtotal = $309,288

Issue Date FY: 2017 ( Subtotal = $309,288 )
2017	2017	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	12	11/8/2016	NON-COMPETING CONTINUATION	$278,359
2017	2017	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	12	5/24/2017	NON-COMPETING CONTINUATION	$30,929
														Subtotal = $309,288

Issue Date FY: 2016 ( Subtotal = $309,288 )
2016	2016	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Research Related to Deafness and Communication Disorders	001	11	11/2/2015	COMPETING CONTINUATION	$309,288
2016	2014	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	022549110		USA	Research Related to Deafness and Communication Disorders	000	10	11/1/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $309,288

Issue Date FY: 2014 ( Subtotal = $258,792 )
2014	2014	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Research Related to Deafness and Communication Disorders	000	10	6/10/2014	NON-COMPETING CONTINUATION	$258,792
														Subtotal = $258,792

Issue Date FY: 2013 ( Subtotal = $245,886 )
2013	2013	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	9	6/18/2013	NON-COMPETING CONTINUATION	$245,886
														Subtotal = $245,886

Issue Date FY: 2012 ( Subtotal = $258,861 )
2012	2012	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	8	5/22/2012	NON-COMPETING CONTINUATION	$258,861
														Subtotal = $258,861

Issue Date FY: 2011 ( Subtotal = $258,895 )
2011	2011	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	7	6/7/2011	NON-COMPETING CONTINUATION	$258,895
														Subtotal = $258,895

Issue Date FY: 2010 ( Subtotal = $267,487 )
2010	2010	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	6	6/10/2010	COMPETING CONTINUATION	$267,487
														Subtotal = $267,487

Issue Date FY: 2009 ( Subtotal = $286,795 )
2009	2009	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	5	6/5/2009	NON-COMPETING CONTINUATION	$286,795
														Subtotal = $286,795

Issue Date FY: 2008 ( Subtotal = $285,348 )
2008	2008	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Research Related to Deafness and Communication Disorders	000	4	5/15/2008	NON-COMPETING CONTINUATION	$285,348
														Subtotal = $285,348

Issue Date FY: 2007 ( Subtotal = $289,106 )
2007	2007	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Research Related to Deafness and Communication Disorders	000	3	5/15/2007	NON-COMPETING CONTINUATION	$289,106
														Subtotal = $289,106

Issue Date FY: 2006 ( Subtotal = $297,741 )
2006	2006	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Research Related to Deafness and Communication Disorders	000	2	5/23/2006	NON-COMPETING CONTINUATION	$297,741
														Subtotal = $297,741

Issue Date FY: 2005 ( Subtotal = $306,453 )
2005	2005	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Research Related to Deafness and Communication Disorders	000	1	6/25/2005	NEW	$306,453
														Subtotal = $306,453

Grand Total All Awards = $5,932,806

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Amygdala-cortical interactions in taste perception and learning

Award Number: R01DC006666

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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