Tuesday, July 1, 2025 7/1/2025

Chaos in human phonation and its measurement

Award Number: R01DC006019
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2003
PERIOD OF PERFORMANCE END DATE: 04/30/2026

Group Awards By:

View Award Description

Chaos in human phonation and its measurement - PROJECT SUMMARY Voice disorders caused by physical injury, voice misuse, physiological disease, and surgery represent a significant social cost, resulting in severe functional and psychological limitations on the lives of millions of Americans. Acoustic analysis represents a promising tool for clinical assessment of voice disorders; however, it has not been widely applied outside of research despite its low cost, objectivity, and non-invasive nature. The intrinsic complexity of voice production and aperiodicity of disordered voice necessitates that acoustic analysis be nonlinear. Current nonlinear parameters are capable of quantifying both normal and disordered phonation; however, existing nonlinear methods fail to comprehensively describe the non-stationary, dynamic elements comprising voice signals. The long-term goal of the proposed research is to expand the utility of nonlinear dynamic analysis in clinical practice as an objective means for detecting vocal dysfunction and monitoring voice rehabilitation following treatment intervention. In Aim 1, excised larynx models will be employed to simulate and investigate physiological conditions contributing to breathy and rough phonation, including extreme subglottal pressures, vocal fold elongation, asymmetrical tension, and benign mass lesions. Diffusive chaos and intrinsic dimension nonlinear analysis will be implemented to evaluate the four different type components present in the corresponding acoustical output and to subsequently construct voice type component profiles (VTCP). Quantitatively describing the VTCP will provide more descriptive information pertaining to the physiological location and conditions underlying pathological phonation. Aim 2 will focus on applying VTCP nonlinear analysis to normal and disordered patients in a variety of voice tasks, such as vowel and consonant utterances and connected speech, and assessment of clinical treatment interventions, including surgical treatment of benign mass lesions and vocal fold paralysis and rehabilitative voice training for esophageal and tracheoesophageal speech. To facilitate wider and more extensive utility of nonlinear dynamic analyses, we will assess the concurrent validity of the VTCPs with the clinically established technique of auditory-perceptual assessment of voice quality. The likely impact of this research is that innovative methods of diffusive chaos and intrinsic dimension nonlinear analysis will provide significant improvements over previous acoustical parameters in both computationally efficiency and voice quality description. Moreover, acoustical analysis of disordered phonation in excised larynges will provide a physical model to examine the physiological and biomechanical conditions underlying pathologic voice production, which remains poorly understood. Lastly, the clinical utility of VTCP analysis as a diagnostic tool for voice disorder detection will be demonstrated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	15	3/4/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $325,125 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	15	4/25/2023	NON-COMPETING CONTINUATION	$325,125
														Subtotal = $325,125

Issue Date FY: 2022 ( Subtotal = $325,125 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	14	4/22/2022	NON-COMPETING CONTINUATION	$325,125
														Subtotal = $325,125

Issue Date FY: 2021 ( Subtotal = $325,125 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	13	4/26/2021	NON-COMPETING CONTINUATION	$325,125
														Subtotal = $325,125

Issue Date FY: 2020 ( Subtotal = $325,125 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	12	4/17/2020	NON-COMPETING CONTINUATION	$325,125
														Subtotal = $325,125

Issue Date FY: 2019 ( Subtotal = $325,125 )
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	004	11	8/30/2019	COMPETING CONTINUATION	$421,042
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	11	3/11/2019	COMPETING CONTINUATION	$325,125
2019	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	003	10	8/30/2019	NON-COMPETING CONTINUATION	-$312,945
2019	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	001	10	8/5/2019	NON-COMPETING CONTINUATION	$0
2019	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	002	9	8/30/2019	NON-COMPETING CONTINUATION	-$108,097
														Subtotal = $325,125

Issue Date FY: 2018 ( Subtotal = $312,945 )
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	10	4/27/2018	NON-COMPETING CONTINUATION	$312,945
														Subtotal = $312,945

Issue Date FY: 2017 ( Subtotal = $312,945 )
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	9	5/1/2017	NON-COMPETING CONTINUATION	$281,650
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	001	9	5/24/2017	NON-COMPETING CONTINUATION	$31,295
														Subtotal = $312,945

Issue Date FY: 2016 ( Subtotal = $312,945 )
2016	2016	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	8	4/19/2016	NON-COMPETING CONTINUATION	$312,945
														Subtotal = $312,945

Issue Date FY: 2015 ( Subtotal = $309,815 )
2015	2015	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	7	5/13/2015	NON-COMPETING CONTINUATION	$309,815
														Subtotal = $309,815

Issue Date FY: 2014 ( Subtotal = $312,945 )
2014	2014	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	6	5/7/2014	COMPETING CONTINUATION	$312,945
														Subtotal = $312,945

Issue Date FY: 2007 ( Subtotal = $311,874 )
2007	2007	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Research Related to Deafness and Communication Disorders	000	5	3/23/2007	NON-COMPETING CONTINUATION	$311,874
														Subtotal = $311,874

Issue Date FY: 2006 ( Subtotal = $321,248 )
2006	2006	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	4	3/15/2006	NON-COMPETING CONTINUATION	$321,248
														Subtotal = $321,248

Issue Date FY: 2005 ( Subtotal = $329,037 )
2005	2005	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	3	4/11/2005	NON-COMPETING CONTINUATION	$329,037
														Subtotal = $329,037

Issue Date FY: 2004 ( Subtotal = $300,112 )
2004	2004	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	2	3/10/2004	NON-COMPETING CONTINUATION	$300,112
														Subtotal = $300,112

Issue Date FY: 2003 ( Subtotal = $302,238 )
2003	2003	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Research Related to Deafness and Communication Disorders	000	1	5/19/2003	NEW	$302,238
														Subtotal = $302,238

Grand Total All Awards = $4,751,729

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Chaos in human phonation and its measurement

Award Number: R01DC006019

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2003

PERIOD OF PERFORMANCE END DATE: 04/30/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer