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Assembly of the Central Olfactory Networks in Drosophila

Award Number: R01DC005982
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2003
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Assembly of the Central Olfactory Networks in Drosophila - PROJECT SUMMARY A central question in neurobiology is how individual neurons precisely connect with each other to form functional circuits during development. Understanding the mechanisms of neural circuit assembly may provide insights into the etiology of human brain disorders. The fruit fly olfactory circuit has been an excellent model to investigate the mechanisms by which wiring specificity of neural circuits arises during development. In this circuit, axons of 50 types of olfactory receptor neurons (ORNs) match precisely with dendrites of 50 corresponding types of second-order olfactory projection neurons (PNs), forming 50 discrete glomeruli in the antennal lobe. This allows olfactory information to be faithfully delivered from peripheral sensory organs to higher brain centers, enabling innate and learned olfactory behavior. Thanks to the continual support of this grant since 2003, our studies have made the Drosophila antennal lobe one of the best-understood circuits in the molecular, cellular, and developmental underpinnings of wiring specificity. During the last grant cycle, we made three key advances: 1) we determined single-cell transcriptomes of PNs and ORNs across development, which have produced differentially expressed genes as candidate wiring molecules and cell-type-specific drivers for labelling and genetically manipulating individual PN and ORN types; 2) we developed a cell-surface proteomic profiling method that allowed us to identify new wiring molecules; 3) we established an explant culture that recapitulates wiring specificity in vivo, allowing us to examine the dynamic process of circuit assembly in wild-type and mutants using time-lapse imaging. In this proposal, we will take advantage of these advances to further investigate the cellular and molecular mechanisms by which the olfactory circuit is assembled and wiring specificity is achieved. Specifically, we will utilize new genetic tools and time-lapse imaging to determine the cellular events that lead to PN dendrite patterning, segregation, and ORN-PN synaptic partner matching. We will investigate the mechanisms by which cell surface receptor teneurins work with putative ligands and downstream signaling molecules to instruct synaptic partner matching. We will also identify additional instructive wiring molecules and study their mechanisms of actions using data from single-cell transcriptomes and in vivo assays that can distinguish attraction vs. repulsion in ligand-receptor interactions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $393,500 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	24	4/1/2026	NON-COMPETING CONTINUATION	$393,500
														Subtotal = $393,500

Issue Date FY: 2025 ( Subtotal = $393,500 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	23	4/21/2025	NON-COMPETING CONTINUATION	$39,350
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	23	3/25/2025	NON-COMPETING CONTINUATION	$354,150
														Subtotal = $393,500

Issue Date FY: 2024 ( Subtotal = $393,500 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	22	3/28/2024	NON-COMPETING CONTINUATION	$393,500
														Subtotal = $393,500

Issue Date FY: 2023 ( Subtotal = $393,500 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	002	21	7/6/2023	COMPETING CONTINUATION	$155,047
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	21	2/21/2023	COMPETING CONTINUATION	$393,500
2023	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	20	7/6/2023	NON-COMPETING CONTINUATION	-$155,047
														Subtotal = $393,500

Issue Date FY: 2022 ( Subtotal = $333,625 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	20	4/22/2022	NON-COMPETING CONTINUATION	$333,625
														Subtotal = $333,625

Issue Date FY: 2021 ( Subtotal = $333,272 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	19	2/19/2021	NON-COMPETING CONTINUATION	$333,272
														Subtotal = $333,272

Issue Date FY: 2020 ( Subtotal = $332,613 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	18	3/18/2020	NON-COMPETING CONTINUATION	$332,613
														Subtotal = $332,613

Issue Date FY: 2019 ( Subtotal = $331,972 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	17	3/12/2019	NON-COMPETING CONTINUATION	$331,972
														Subtotal = $331,972

Issue Date FY: 2018 ( Subtotal = $331,350 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	002	16	9/5/2018	COMPETING CONTINUATION	$19
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	16	4/6/2018	COMPETING CONTINUATION	$331,350
2018	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	15	9/5/2018	NON-COMPETING CONTINUATION	-$19
														Subtotal = $331,350

Issue Date FY: 2017 ( Subtotal = $333,625 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	15	5/24/2017	NON-COMPETING CONTINUATION	$33,363
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	15	3/16/2017	NON-COMPETING CONTINUATION	$300,262
														Subtotal = $333,625

Issue Date FY: 2016 ( Subtotal = $333,625 )
2016	2016	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	14	3/18/2016	EXTENSION WITH OR WITHOUT FUNDS	$333,625
														Subtotal = $333,625

Issue Date FY: 2015 ( Subtotal = $330,288 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	13	3/18/2015	NON-COMPETING CONTINUATION	$330,288
														Subtotal = $330,288

Issue Date FY: 2014 ( Subtotal = $333,625 )
2014	2014	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	12	3/3/2014	NON-COMPETING CONTINUATION	$333,625
														Subtotal = $333,625

Issue Date FY: 2013 ( Subtotal = $333,625 )
2013	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	11	4/15/2013	COMPETING CONTINUATION	$333,625
														Subtotal = $333,625

Issue Date FY: 2012 ( Subtotal = $287,557 )
2012	2012	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	10	3/7/2012	NON-COMPETING CONTINUATION	$287,557
														Subtotal = $287,557

Issue Date FY: 2011 ( Subtotal = $287,107 )
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	9	3/23/2011	NON-COMPETING CONTINUATION	$266,938
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	9	6/3/2011	NON-COMPETING CONTINUATION	$20,169
														Subtotal = $287,107

Issue Date FY: 2010 ( Subtotal = $297,147 )
2010	2010	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	8	2/26/2010	NON-COMPETING CONTINUATION	$297,147
														Subtotal = $297,147

Issue Date FY: 2009 ( Subtotal = $302,175 )
2009	2009	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	7	3/13/2009	NON-COMPETING CONTINUATION	$302,175
														Subtotal = $302,175

Issue Date FY: 2008 ( Subtotal = $302,175 )
2008	2008	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	6	2/15/2008	COMPETING CONTINUATION	$302,175
														Subtotal = $302,175

Issue Date FY: 2007 ( Subtotal = $336,125 )
2007	2007	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	5	2/27/2007	NON-COMPETING CONTINUATION	$336,125
														Subtotal = $336,125

Issue Date FY: 2006 ( Subtotal = $346,434 )
2006	2006	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	4	1/27/2006	NON-COMPETING CONTINUATION	$346,434
														Subtotal = $346,434

Issue Date FY: 2005 ( Subtotal = $355,040 ) (Continued on the next page)
Grand Total All Awards = $8,123,675

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Assembly of the Central Olfactory Networks in Drosophila

Award Number: R01DC005982

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2003

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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