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Assembly of the Central Olfactory Networks in Drosophila

Award Number: R01DC005982
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

From insects to mammals, olfactory receptor neurons (ORNs) expressing the same odorant receptor target their axonal projections to specific glomerular destinations in the antennal lobe/olfactory bulb, creating an odor map in these first olfactory structures of the central nervous system. In the fly, axons of 50 classes of ORNs match precisely with dendrites of corresponding 50 classes of second order olfactory projection neurons (PNs) to form the 50 glomeruli of the antennal lobe. Olfactory information is thus faithfully delivered from sensory organs in the periphery to higher brain centers, enabling innate and learned olfactory behavior. Thanks to the continual support of this grant since 2003, our studies have made the Drosophila antennal lobe one of the best-understood circuits in terms of the molecular, cellular, and developmental underpinnings of wiring specificity. We provided a detailed description of the wiring process with single-cell resolution, finding that PN dendrites pre-pattern the antennal lobe prior to ORN axon invasion. We discovered the importance of PN dendrite-dendrite, ORN axon-axon, and PN dendrite-ORN axon interactions and some of the underlying molecular mechanisms. Moreover, we recently developed methods to profile the transcriptomes of individual olfactory neurons, and to visualize them as they make wiring decisions using time-lapse imaging. In this renewal, we propose to combine live imaging, single-cell RNA-sequencing, proteomic approaches with state-of-the-art genetic manipulations to address the following three questions: 1) how do ORN axons choose a specific trajectory when they first reach the antennal lobe? 2) How do PN dendrites establish discrete boundaries and targeting specificity? 3) How do ORN axons find their partner PN dendrites? The completion of the proposed studies will allow us to gain a more comprehensive understanding of the combinatorial codes that determine wiring specificity, and cell biological mechanisms that underlying the execution of wiring decisions. These studies will contribute to our understanding of a central problem in developmental neurobiology: how wiring specificity of neural circuits is achieved during development. By uncovering the molecules and mechanisms inherent to the fly olfactory circuit, we have already provided insight into constructing more complex neural circuits in the mammalian brain, and established links between neural circuit wiring and disorders of the human brain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $393,500 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	22	3/28/2024	NON-COMPETING CONTINUATION	$393,500
														Subtotal = $393,500

Issue Date FY: 2023 ( Subtotal = $393,500 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	002	21	7/6/2023	COMPETING CONTINUATION	$155,047
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	21	2/21/2023	COMPETING CONTINUATION	$393,500
2023	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	20	7/6/2023	NON-COMPETING CONTINUATION	-$155,047
														Subtotal = $393,500

Issue Date FY: 2022 ( Subtotal = $333,625 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	20	4/22/2022	NON-COMPETING CONTINUATION	$333,625
														Subtotal = $333,625

Issue Date FY: 2021 ( Subtotal = $333,272 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	19	2/19/2021	NON-COMPETING CONTINUATION	$333,272
														Subtotal = $333,272

Issue Date FY: 2020 ( Subtotal = $332,613 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	18	3/18/2020	NON-COMPETING CONTINUATION	$332,613
														Subtotal = $332,613

Issue Date FY: 2019 ( Subtotal = $331,972 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	17	3/12/2019	NON-COMPETING CONTINUATION	$331,972
														Subtotal = $331,972

Issue Date FY: 2018 ( Subtotal = $331,350 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	16	4/6/2018	COMPETING CONTINUATION	$331,350
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	002	16	9/5/2018	COMPETING CONTINUATION	$19
2018	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	15	9/5/2018	NON-COMPETING CONTINUATION	-$19
														Subtotal = $331,350

Issue Date FY: 2017 ( Subtotal = $333,625 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	15	3/16/2017	NON-COMPETING CONTINUATION	$300,262
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	15	5/24/2017	NON-COMPETING CONTINUATION	$33,363
														Subtotal = $333,625

Issue Date FY: 2016 ( Subtotal = $333,625 )
2016	2016	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	14	3/18/2016	EXTENSION WITH OR WITHOUT FUNDS	$333,625
														Subtotal = $333,625

Issue Date FY: 2015 ( Subtotal = $330,288 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	13	3/18/2015	NON-COMPETING CONTINUATION	$330,288
														Subtotal = $330,288

Issue Date FY: 2014 ( Subtotal = $333,625 )
2014	2014	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	12	3/3/2014	NON-COMPETING CONTINUATION	$333,625
														Subtotal = $333,625

Issue Date FY: 2013 ( Subtotal = $333,625 )
2013	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	11	4/15/2013	COMPETING CONTINUATION	$333,625
														Subtotal = $333,625

Issue Date FY: 2012 ( Subtotal = $287,557 )
2012	2012	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	10	3/7/2012	NON-COMPETING CONTINUATION	$287,557
														Subtotal = $287,557

Issue Date FY: 2011 ( Subtotal = $287,107 )
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	9	3/23/2011	NON-COMPETING CONTINUATION	$266,938
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	9	6/3/2011	NON-COMPETING CONTINUATION	$20,169
														Subtotal = $287,107

Issue Date FY: 2010 ( Subtotal = $297,147 )
2010	2010	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	8	2/26/2010	NON-COMPETING CONTINUATION	$297,147
														Subtotal = $297,147

Issue Date FY: 2009 ( Subtotal = $302,175 )
2009	2009	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	7	3/13/2009	NON-COMPETING CONTINUATION	$302,175
														Subtotal = $302,175

Issue Date FY: 2008 ( Subtotal = $302,175 )
2008	2008	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	6	2/15/2008	COMPETING CONTINUATION	$302,175
														Subtotal = $302,175

Issue Date FY: 2007 ( Subtotal = $336,125 )
2007	2007	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	5	2/27/2007	NON-COMPETING CONTINUATION	$336,125
														Subtotal = $336,125

Issue Date FY: 2006 ( Subtotal = $346,434 )
2006	2006	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	4	1/27/2006	NON-COMPETING CONTINUATION	$346,434
														Subtotal = $346,434

Issue Date FY: 2005 ( Subtotal = $355,040 )
2005	2005	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	3	1/28/2005	NON-COMPETING CONTINUATION	$355,040
														Subtotal = $355,040

Issue Date FY: 2004 ( Subtotal = $359,651 )
2004	2004	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	2	2/4/2004	NON-COMPETING CONTINUATION	$359,651
														Subtotal = $359,651

Issue Date FY: 2003 ( Subtotal = $348,644 )
2003	2003	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	1		NEW	$348,644
														Subtotal = $348,644

Grand Total All Awards = $7,336,675

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Assembly of the Central Olfactory Networks in Drosophila

Award Number: R01DC005982

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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