Thursday, December 26, 2024 12/26/2024

Analysis of Chemosensory Receptor Genes

Award Number: R01DC004729
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

PROJECT SUMMARY The long-term goal of this project is to elucidate basic principles of chemosensory perception. It seeks to explain at the molecular, cellular, and circuit levels how chemosensory information is encoded. The experimental plan takes advantage of the fruit fly Drosophila melanogaster as a model system, which allows incisive molecular genetic analysis of chemosensory receptors, neurons, and circuits, and of the functions they perform. The project considers a kind of chemical information that underlies one of the most ancient and fundamental of biological problems: how an animal detects a mate of its own species. A cluster of four ionotropic receptor genes, IR52a, IR52b, IR52c, and IR52d, the chemosensory neurons in which they are expressed, and the circuitry they activate will be analyzed to test hypotheses about their role in mate detection. The first aim will provide a rigorous analysis of the expression and function of these genes in Drosophila melanogaster, as well as analyzing their counterparts from a related species. The experimental plan is designed to test hypotheses about the molecular logic of mate detection. The second aim takes advantage of a recent advance in electrophysiology that allows new analysis of the cellular responses to pheromones. The proposed experiments are designed to provide pheromone-to-neuron and pheromone-to-receptor maps of a chemosensory organ. The aim may also provide a new "empty pheromone neuron" system useful in analyzing pheromone receptors of a variety of species and in identifying compounds that activate or inhibit them. The third aim exploits a new means of labeling neural circuits. It measures the responses of second-order neurons to pheromones. It also tests the hypothesis that pheromonal input from taste neurons is combined with olfactory input at an early stage of processing, before ultimately being translated into behavioral output. Diseases carried by insects afflict hundreds of millions of people each year. These insects detect their mates and their human hosts largely through their chemosensory systems. Advances in understanding these chemosensory systems may lead to new means of manipulating them and of thereby controlling these insect vectors of human disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $318,631 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	25	12/5/2024	NON-COMPETING CONTINUATION	$318,631
														Subtotal = $318,631

Issue Date FY: 2024 ( Subtotal = $354,116 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	24	5/2/2024	NON-COMPETING CONTINUATION	$35,412
2024	2024	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	24	1/3/2024	NON-COMPETING CONTINUATION	$318,704
														Subtotal = $354,116

Issue Date FY: 2023 ( Subtotal = $354,195 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	23	1/12/2023	NON-COMPETING CONTINUATION	$35,420
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	23	12/2/2022	NON-COMPETING CONTINUATION	$318,775
														Subtotal = $354,195

Issue Date FY: 2022 ( Subtotal = $354,270 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	22	12/15/2021	NON-COMPETING CONTINUATION	$318,843
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	22	4/19/2022	NON-COMPETING CONTINUATION	$35,427
														Subtotal = $354,270

Issue Date FY: 2021 ( Subtotal = $354,341 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	21	12/21/2020	COMPETING CONTINUATION	$354,341
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	002	21	6/22/2021	COMPETING CONTINUATION	$718
2021	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	20	6/22/2021	NON-COMPETING CONTINUATION	-$718
														Subtotal = $354,341

Issue Date FY: 2020 ( Subtotal = $354,645 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	20	12/12/2019	NON-COMPETING CONTINUATION	$319,180
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	20	1/15/2020	NON-COMPETING CONTINUATION	$35,465
														Subtotal = $354,645

Issue Date FY: 2019 ( Subtotal = $343,001 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	19	12/20/2018	NON-COMPETING CONTINUATION	$343,001
														Subtotal = $343,001

Issue Date FY: 2018 ( Subtotal = $343,549 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	18	4/3/2018	NON-COMPETING CONTINUATION	$34,355
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	18	12/28/2017	NON-COMPETING CONTINUATION	$309,194
														Subtotal = $343,549

Issue Date FY: 2017 ( Subtotal = $343,549 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	17	12/14/2016	NON-COMPETING CONTINUATION	$309,194
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	17	5/24/2017	NON-COMPETING CONTINUATION	$34,355
														Subtotal = $343,549

Issue Date FY: 2016 ( Subtotal = $332,498 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	16	1/7/2016	COMPETING CONTINUATION	$332,498
2016	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	065208047	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	15	1/7/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $332,498

Issue Date FY: 2015 ( Subtotal = $349,833 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	15	1/13/2015	NON-COMPETING CONTINUATION	$31,803
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	15	12/17/2014	NON-COMPETING CONTINUATION	$318,030
														Subtotal = $349,833

Issue Date FY: 2014 ( Subtotal = $353,380 )
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	14	12/4/2013	NON-COMPETING CONTINUATION	$318,042
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	14	2/5/2014	NON-COMPETING CONTINUATION	$35,338
														Subtotal = $353,380

Issue Date FY: 2013 ( Subtotal = $335,219 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	13	11/14/2012	NON-COMPETING CONTINUATION	$317,575
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	13	5/10/2013	NON-COMPETING CONTINUATION	$17,644
														Subtotal = $335,219

Issue Date FY: 2012 ( Subtotal = $351,816 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	12	1/26/2012	NON-COMPETING CONTINUATION	$35,182
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	12	1/4/2012	NON-COMPETING CONTINUATION	$316,634
														Subtotal = $351,816

Issue Date FY: 2011 ( Subtotal = $351,298 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	11	12/30/2010	COMPETING CONTINUATION	$351,298
														Subtotal = $351,298

Issue Date FY: 2010 ( Subtotal = $329,318 )
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	10	12/30/2009	NON-COMPETING CONTINUATION	$329,318
														Subtotal = $329,318

Issue Date FY: 2009 ( Subtotal = $332,655 )
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	001	9	3/16/2009	NON-COMPETING CONTINUATION	$33,266
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	9	12/12/2008	NON-COMPETING CONTINUATION	$299,389
														Subtotal = $332,655

Issue Date FY: 2008 ( Subtotal = $332,664 )
2008	2008	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Research Related to Deafness and Communication Disorders	000	8	12/20/2007	NON-COMPETING CONTINUATION	$332,664
														Subtotal = $332,664

Grand Total All Awards = $8,731,925

Page 1 of 2 (64 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Analysis of Chemosensory Receptor Genes

Award Number: R01DC004729

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer